3．骨と心血管を巡る破骨細胞形成抑制因子、 「オステオプロテゲリン」
「はじめに」超高齢化社会に突入したわが国において, 「がん」や「認知症」と共に, 「心不全」の発症予防対策は喫緊の課題である. 心不全はいったん発症すると, 急性増悪, 寛解を反復しながら難治化する. アンジオテンシン変換酵素阻害薬やβ遮断薬, 心臓再同期療法等により心不全の生命予後は改善してきたが, 高齢者のそれは未だに悪く, 慢性腎臓病, 慢性閉塞性肺疾患, 貧血などの "併存疾患" が予後に影響する. また, 心不全患者は骨粗鬆による腰椎骨折のリスクが高く, 高齢者心不全患者の10%に椎体圧迫骨折を認めたという. これらの調査研究から高齢者の慢性心不全の管理には, &...
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| Published in | CIRCULATION CONTROL Vol. 39; no. 3; pp. 157 - 159 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本循環制御医学会
2018
Japan Society of Circulation Control in Medicine |
| Online Access | Get full text |
| ISSN | 0389-1844 |
| DOI | 10.11312/ccm.39.157 |
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| Abstract | 「はじめに」超高齢化社会に突入したわが国において, 「がん」や「認知症」と共に, 「心不全」の発症予防対策は喫緊の課題である. 心不全はいったん発症すると, 急性増悪, 寛解を反復しながら難治化する. アンジオテンシン変換酵素阻害薬やβ遮断薬, 心臓再同期療法等により心不全の生命予後は改善してきたが, 高齢者のそれは未だに悪く, 慢性腎臓病, 慢性閉塞性肺疾患, 貧血などの "併存疾患" が予後に影響する. また, 心不全患者は骨粗鬆による腰椎骨折のリスクが高く, 高齢者心不全患者の10%に椎体圧迫骨折を認めたという. これらの調査研究から高齢者の慢性心不全の管理には, "多元的なアプローチ" が必要であることを意味する. さらには, 心不全とこれら併存疾患の間に共通の発症基盤の存在することが示唆される. 加齢, 慢性腎臓病, ビタミンD欠乏, 低体重, 身体活動の低下などは心不全と骨粗鬆症の間に共有される背景因子であろう. |
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| AbstractList | 「はじめに」超高齢化社会に突入したわが国において, 「がん」や「認知症」と共に, 「心不全」の発症予防対策は喫緊の課題である. 心不全はいったん発症すると, 急性増悪, 寛解を反復しながら難治化する. アンジオテンシン変換酵素阻害薬やβ遮断薬, 心臓再同期療法等により心不全の生命予後は改善してきたが, 高齢者のそれは未だに悪く, 慢性腎臓病, 慢性閉塞性肺疾患, 貧血などの "併存疾患" が予後に影響する. また, 心不全患者は骨粗鬆による腰椎骨折のリスクが高く, 高齢者心不全患者の10%に椎体圧迫骨折を認めたという. これらの調査研究から高齢者の慢性心不全の管理には, "多元的なアプローチ" が必要であることを意味する. さらには, 心不全とこれら併存疾患の間に共通の発症基盤の存在することが示唆される. 加齢, 慢性腎臓病, ビタミンD欠乏, 低体重, 身体活動の低下などは心不全と骨粗鬆症の間に共有される背景因子であろう. |
| Author | 北村, 和雄 鶴田, 敏博 宇田川, 信之 |
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| References | Tsuruda T, Sekita-Hatakeyama Y, Hao Y, et al: Angiotensin II stimulation of cardiac hypertrophy and functional decompensation in steoprotegerindeficient mice. Hypertension 2016; 67: 848-56. Hao Y, Tsuruda T, Sekita-Hatakeyama Y, et al: Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene. Cardiovasc Res 2016; 110: 62-72. Mitsudo SM: Chronic idiopathic hyperphosphatasia associated with pseudoxanthoma elasticum. J Bone Joint Surg Am 1971; 53: 303-14. Yasuda H, Shima N, Nakagawa N, et al: Identity of osteoclastogenesis inhibitory factor(OCIF) and osteoprotegerin(OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 1998; 139: 1329-37. Simonet WS, Lacey DL, Dunstan CR, et al: Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997; 89: 309-19. Zittermann A, Schleithoff SS, Koerfer R: Vitamin D insufficiency in congestive heart failure: why and what to do about it? Heart Fail Rev 2006; 11: 25-33. Ueland T, Yndestad A, Øie E, et al: Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure. Circulation 2005; 111: 2461-8. Lyons KJ, Majumdar SR, Ezekowitz JA: The unrecognized burden of osteoporosis-related vertebral fractures in patients with heart failure. Circ Heart Fail 2011; 4: 419-24. Tsuda E, Goto M, Mochizuki S, et al: Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 1997; 234: 137-42. Pocock SJ, McMurray JJ, Dobson J, et al: Weight loss and mortality risk in patients with chronic heart failure in the candesartan in heart failure: assessment of reduction in mortality and morbidity(CHARM) programme. Eur Heart J 2008; 29: 2641-50. van Deursen VM, Urso R, Laroche C, et al: Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey. Eur J Heart Fail 2014; 16: 103-11. Koyama S, Tsuruda T, Ideguchi T, et al: Osteoprotegerin is secreted into the coronary circulation: a possible association with the renin-angiotensin system and cardiac hypertrophy. Horm Metab Res 2014; 46: 581-6. Ueland T, Dahl CP, Kjekshus J, et al: Osteoprotegerin predicts progression of chronic heart failure: results from CORONA. Circ Heart Fail 2011; 4: 145-52. van Diepen S, Majumdar SR, Bakal JA, et al: Heart failure is a risk factor for orthopedic fracture: a population-based analysis of 16,294 patients. Circulation 2008; 118: 1946-52. Polyzos SA, Cundy T, Mantzoros CS: Juvenile Paget disease. Metabolism 2018; 80: 15-26. Whyte MP, Obrecht SE, Finnegan PM, et al: Osteoprotegerin deficiency and juvenile Paget's disease. N Engl J Med 2002; 347: 175-84. |
| References_xml | – reference: Pocock SJ, McMurray JJ, Dobson J, et al: Weight loss and mortality risk in patients with chronic heart failure in the candesartan in heart failure: assessment of reduction in mortality and morbidity(CHARM) programme. Eur Heart J 2008; 29: 2641-50. – reference: Ueland T, Yndestad A, Øie E, et al: Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure. Circulation 2005; 111: 2461-8. – reference: Yasuda H, Shima N, Nakagawa N, et al: Identity of osteoclastogenesis inhibitory factor(OCIF) and osteoprotegerin(OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 1998; 139: 1329-37. – reference: Koyama S, Tsuruda T, Ideguchi T, et al: Osteoprotegerin is secreted into the coronary circulation: a possible association with the renin-angiotensin system and cardiac hypertrophy. Horm Metab Res 2014; 46: 581-6. – reference: Zittermann A, Schleithoff SS, Koerfer R: Vitamin D insufficiency in congestive heart failure: why and what to do about it? Heart Fail Rev 2006; 11: 25-33. – reference: Simonet WS, Lacey DL, Dunstan CR, et al: Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997; 89: 309-19. – reference: Ueland T, Dahl CP, Kjekshus J, et al: Osteoprotegerin predicts progression of chronic heart failure: results from CORONA. Circ Heart Fail 2011; 4: 145-52. – reference: Tsuda E, Goto M, Mochizuki S, et al: Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 1997; 234: 137-42. – reference: Tsuruda T, Sekita-Hatakeyama Y, Hao Y, et al: Angiotensin II stimulation of cardiac hypertrophy and functional decompensation in steoprotegerindeficient mice. Hypertension 2016; 67: 848-56. – reference: van Deursen VM, Urso R, Laroche C, et al: Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey. Eur J Heart Fail 2014; 16: 103-11. – reference: Lyons KJ, Majumdar SR, Ezekowitz JA: The unrecognized burden of osteoporosis-related vertebral fractures in patients with heart failure. Circ Heart Fail 2011; 4: 419-24. – reference: Hao Y, Tsuruda T, Sekita-Hatakeyama Y, et al: Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene. Cardiovasc Res 2016; 110: 62-72. – reference: van Diepen S, Majumdar SR, Bakal JA, et al: Heart failure is a risk factor for orthopedic fracture: a population-based analysis of 16,294 patients. Circulation 2008; 118: 1946-52. – reference: Polyzos SA, Cundy T, Mantzoros CS: Juvenile Paget disease. Metabolism 2018; 80: 15-26. – reference: Whyte MP, Obrecht SE, Finnegan PM, et al: Osteoprotegerin deficiency and juvenile Paget's disease. N Engl J Med 2002; 347: 175-84. – reference: Mitsudo SM: Chronic idiopathic hyperphosphatasia associated with pseudoxanthoma elasticum. J Bone Joint Surg Am 1971; 53: 303-14. |
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| Snippet | 「はじめに」超高齢化社会に突入したわが国において, 「がん」や「認知症」と共に, 「心不全」の発症予防対策は喫緊の課題である. 心不全はいったん発症すると, 急性増悪, 寛解を... |
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| Title | 3．骨と心血管を巡る破骨細胞形成抑制因子、 「オステオプロテゲリン」 |
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