歯周病ハイリスク患者における宿主応答の解析
長期間メインテナンスを受けている患者群において歯周病ハイリスク患者を選別し, 細菌学的ならびに免疫学的検討を行った。被験者は初期治療終了後の再評価から5年以上メインテナンスを受けている患者21名のうち, PD悪化率5%以上を示す患者9名をハイリスク患者とした。5年目のリコール時に臨床パラメーターの測定, 採血ならびに歯肉縁下プラークの採取を行った。その結果, ハイリスク群は有意に高いBOP (+) 部位の出現頻度を示したが, 末梢血リンパ球のAMLR, CD4+/CD8+比, CD4+CD45RA+ならびにCD4+CD45RA+細胞率に関して差はなかった。歯肉縁下プラーク中のAv, Pg, P...
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| Published in | 日本歯周病学会会誌 Vol. 36; no. 4; pp. 857 - 870 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本歯周病学会
1994
日本歯周病学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-0110 1880-408X |
| DOI | 10.2329/perio.36.857 |
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| Abstract | 長期間メインテナンスを受けている患者群において歯周病ハイリスク患者を選別し, 細菌学的ならびに免疫学的検討を行った。被験者は初期治療終了後の再評価から5年以上メインテナンスを受けている患者21名のうち, PD悪化率5%以上を示す患者9名をハイリスク患者とした。5年目のリコール時に臨床パラメーターの測定, 採血ならびに歯肉縁下プラークの採取を行った。その結果, ハイリスク群は有意に高いBOP (+) 部位の出現頻度を示したが, 末梢血リンパ球のAMLR, CD4+/CD8+比, CD4+CD45RA+ならびにCD4+CD45RA+細胞率に関して差はなかった。歯肉縁下プラーク中のAv, Pg, Pi, Aaの検出率に差は認められなかったものの, ハイリスク群において検索を行った菌種のうちAvについてのみ有意に低い血清抗体価が認められた。 |
|---|---|
| AbstractList | 長期間メインテナンスを受けている患者群において歯周病ハイリスク患者を選別し, 細菌学的ならびに免疫学的検討を行った。被験者は初期治療終了後の再評価から5年以上メインテナンスを受けている患者21名のうち, PD悪化率5%以上を示す患者9名をハイリスク患者とした。5年目のリコール時に臨床パラメーターの測定, 採血ならびに歯肉縁下プラークの採取を行った。その結果, ハイリスク群は有意に高いBOP (+) 部位の出現頻度を示したが, 末梢血リンパ球のAMLR, CD4+/CD8+比, CD4+CD45RA+ならびにCD4+CD45RA+細胞率に関して差はなかった。歯肉縁下プラーク中のAv, Pg, Pi, Aaの検出率に差は認められなかったものの, ハイリスク群において検索を行った菌種のうちAvについてのみ有意に低い血清抗体価が認められた。 |
| Author | 村上, 伸也 北村, 正博 酒井, 洋子 三木, 靖夫 三好, 美貴 岡田, 宏 島内, 英俊 |
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| DOI | 10.2329/perio.36.857 |
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| References | Maiden, M.F.J., Caman, R. J., Curtis, M.A., Gillett, I. R., Griffiths, G. S., Sterne, J. A. C., Wilton, J.M.A. and Johnson, N. W.: Detection of high-risk groups and individuals for periodontal disease. Laboratory markers based on the microbiological analysis of subgingival plaque. J. Clin. Periodontol., 17: 1-13, 1990. Johnson, N. W., Griffiths, G. S., Wilton, J.M.A., Maiden, M. F. J., Curtis, M. A., Gillett, I. R., Wilson, D.T. and Stern, J. A. C.: Detection of high-risk groups and individuals for periodontal diseases. Evidence for the existence of high-risk groups and individuals and approaches to their detection. J. Clin. Periodontol., 15: 276-282, 1988. Sanders, M. E., Makgoba, M. W. and Shaw, S.: Human naive and memory T cells: Reinterpretation of helper-inducer and suppressor inducer subsets. Immunology today, 9: 195-198, 1988. Ogawa, T., McGhee, M. L., Moldoveanu. Z., Hamada, S., Mestecky, J., McGhee, J. R. and Kiyono, H.: Bacteroides specific IgG and IgA subclass secreting antibody-secreting cells isolated from chronically inflamed gingival tissues. Clin. Exp. Immunol. 76: 103-110, 1989. 藤本直樹: 成人性歯周炎患者の末梢血自己リンパ球混合培養反応. 日歯周誌, 32: 355-369, 1990. Wilton, J. M. A., Griffiths, G. S., Curtis, M. A., Maiden, M. F. J., Gilltt, I. R., Wilson, D. T., Sterne, J. A. C. and Johnson, N. W.: Detection of high-risk groups and individuals for periodontal diseases. Systemic predisposition and markers of general health. J. Clin, Periodontol., 15: 339-346, 1988. Fine, D. H. and Mandel, I. D.: Indicators of periodontal disease activity: An evaluation. J. Clin. Periodontol. 13: 533-546, 1986. Albandar, J. M., Buischi, Y. A. P. and Barbosa, M. F. Z.: Destructive forms of periodontal disease in adolescents. A 3-year longitudinal study. J. Periodontol., 62: 370-376, 1991. Haffajee, A. D., Socransky, S. S. and Goodson, J. M.: Clinical parameters as predictors of destructive periodontal disease activity. J. Clin. Periodontol., 10: 257-265, 1983. Schei, 0., Waerhang, J., Lovdal, A. and Arno, A.: Alveolar bone loss as related to oral hygiene and age. J. Periodontol., 30: 7-16, 1959. Socransky, S. S., Haffajee, A. D., Goodson, J. M. and Lindhe, j.: New concepts of destructive periodontal disease. J. Clin. Periodontol., 11: 21-32, 1984. Silness, J. and Loe, H.: Periodontal disease in pregnancy, II. Correlation between oral hygiene and periodontal condition. Acta Odont. Scand., 22: 121-135, 1964. Haffajee, A. D., Socransky, S. S. and Goodson, J. M.: Periodontal disease activity. J. Periodont. Res., 17: 521-522, 1982. 三木靖夫, 大竹 毅, 島袋善夫, 北村正博, 島内英俊, 村上伸也, 岡田, 宏: 長期経過症例における歯周病ハイリスク患者の検討. 日歯周誌35: 409-416, 1993. Loe, H. and Silness, J.: Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odont. Scand., 21: 533-551, 1963. Cooper, P. G., Caton J. G. and Polson A. M.: Cell populations associated with gingival bleeding. J. Periodontol., 54: 497-502, 1983. Griffiths, G. S., Wilton, J. M. A., Curtis, M. A., Maiden, M. F. J., Gillett, I. R., Wilson, D. T., Sterne. J. A. C. and Johnson, N. W.: Detection of high-risk groups and individuals for periodontal diseases. Clinical assessment of the periodontium. J. Clin Periodontol., 15: 403-410, 1988. Matter, L., Wilhelm, J. A., Angehrn, W., Skvarik, F. and Schopfer, K.: Selective antibody deficiency and recurrent pneumococcal bacteremia in a patient with Sjogren's syndrome, hyperimmunogloburinemia G, and deficiencies of IgG 2 and IgG 4. N. Engl. J. Med. 312: 1039-1042, 1985. Akbar, A. N., Salmon, M. and Janosgy, G.: The synergy between naive and memory T cells during activation. Immunology today 12: 184-188, 1991. Curtis, M. A., Gillett, I. R., Griffiths, G. S., Maiden M. F. J., Sterne, J. A. C., Wilson, D. T. and Johnson, N. W.: Detection of high-risk groups and individuals for periodontal diseases. Laboratory markers from analysis of gingival crevicular fluid. J. Clin. Periodontol., 16: 1-11, 1989. 酒井洋子, 伊藤博夫, 横小路貴義, 岡田, 宏: Po r垂phyromonas gingivalisに対するIgGサブクラス抗体の定量的測定法の確立. 日歯周誌35 (春季特別号) : 64, 1993. Socransky, S. S.: Microbiology of Periodontal disease. Present status and future consideration. J. Periodontol., 48: 497-504, 1977. Ebersole J. L., Taubman, M.A., Smith, D. J. and Haffajee, A. D.: Effect of subgingival scaling on systemic antibody responses to oral microorganisms. Infect. Immun. 48: 534-539, 1985. Burton, R.: Mechanisms of oral colonization. Slots, J. and Taubman, M.A., Contemporary Oral Microbiology and Immunology, Mosby, St. Louis, 1992, 283-298. Greenstein G., Caton, J.G. and Polson, A. M.: Histologic characteristic associated with bleeding after probing and visual signs of inflammations. J. Periodontol., 52: 420-425, 1981. Kornman, K.S.: Nature of periodontal diseases: assessment and diagnosis. J. Periodont. Res. 22: 192-204, 1987. Cisar, S. O., Sandberg, A.L. and Mergenhagen, S. E.: The function and distribution of different fimbriae on strains of Actinomyces viscosus and Actinomyces naeslundii. J. Dent Res. 63: 393-396, 1984. Haffajee, A. D., Socransky, S. S. and Goodson, J. M.: Comparison of different data analyses for detecting changes in attachment level. J. Clin. Periodontol., 10: 298-310, 1983. 神山 章: 歯周病の診断に関する細菌学的研究. 日歯周誌, 31: 360-379, 1989. Slots, J. and Listgarten M. A.: Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in human periodontal diseases. J. Clin. Periodontol. 15: 85-93, 1988. Dzink, J. L., Socransky, S. S. and Haffajee, A. D.: The predominant cultivable microbiota of active and inactive lesions of destructive periodontal disease. J. Clin. Periodontol., 15: 316-323, 1988. Goodson, J. M., Tanner, A. C. R., Haffajee, A. D., Sornberger, G. C. and Socransky, S. S.: Patterns and proregression of advanced destructive periodontal disease. J. Clin. Periodontol., 9: 472-481, 1982 Albandar, J.M., Rise, J., Gjermo, P. and Johansen, J.R.: Radiographic quantification of alveolar bone level changes. A 2-year longitudinal study in man. J. Clin. Periodontol., 13: 195-200, 1986. Beale, M. G., MacDernoff, R . P., Stacey, M. C., Nash, G.S., Hahn, B. H., Seiden, M. V., Jacobs S. L. B. and Lowenstein, S. P.: Stimulating cell types in the autologous mixed leukocyte reaction in man. J. Immunol., 124: 227-232, 1980. |
| References_xml | – reference: Matter, L., Wilhelm, J. A., Angehrn, W., Skvarik, F. and Schopfer, K.: Selective antibody deficiency and recurrent pneumococcal bacteremia in a patient with Sjogren's syndrome, hyperimmunogloburinemia G, and deficiencies of IgG 2 and IgG 4. N. Engl. J. Med. 312: 1039-1042, 1985. – reference: Ogawa, T., McGhee, M. L., Moldoveanu. Z., Hamada, S., Mestecky, J., McGhee, J. R. and Kiyono, H.: Bacteroides specific IgG and IgA subclass secreting antibody-secreting cells isolated from chronically inflamed gingival tissues. Clin. Exp. Immunol. 76: 103-110, 1989. – reference: Schei, 0., Waerhang, J., Lovdal, A. and Arno, A.: Alveolar bone loss as related to oral hygiene and age. J. Periodontol., 30: 7-16, 1959. – reference: 酒井洋子, 伊藤博夫, 横小路貴義, 岡田, 宏: Po r垂phyromonas gingivalisに対するIgGサブクラス抗体の定量的測定法の確立. 日歯周誌35 (春季特別号) : 64, 1993. – reference: 藤本直樹: 成人性歯周炎患者の末梢血自己リンパ球混合培養反応. 日歯周誌, 32: 355-369, 1990. – reference: Cisar, S. O., Sandberg, A.L. and Mergenhagen, S. E.: The function and distribution of different fimbriae on strains of Actinomyces viscosus and Actinomyces naeslundii. J. Dent Res. 63: 393-396, 1984. – reference: Loe, H. and Silness, J.: Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odont. Scand., 21: 533-551, 1963. – reference: Kornman, K.S.: Nature of periodontal diseases: assessment and diagnosis. J. Periodont. Res. 22: 192-204, 1987. – reference: Maiden, M.F.J., Caman, R. J., Curtis, M.A., Gillett, I. R., Griffiths, G. S., Sterne, J. A. C., Wilton, J.M.A. and Johnson, N. W.: Detection of high-risk groups and individuals for periodontal disease. Laboratory markers based on the microbiological analysis of subgingival plaque. J. Clin. Periodontol., 17: 1-13, 1990. – reference: Sanders, M. E., Makgoba, M. W. and Shaw, S.: Human naive and memory T cells: Reinterpretation of helper-inducer and suppressor inducer subsets. Immunology today, 9: 195-198, 1988. – reference: Fine, D. H. and Mandel, I. D.: Indicators of periodontal disease activity: An evaluation. J. Clin. Periodontol. 13: 533-546, 1986. – reference: Dzink, J. L., Socransky, S. S. and Haffajee, A. D.: The predominant cultivable microbiota of active and inactive lesions of destructive periodontal disease. J. Clin. Periodontol., 15: 316-323, 1988. – reference: Albandar, J. M., Buischi, Y. A. P. and Barbosa, M. F. Z.: Destructive forms of periodontal disease in adolescents. A 3-year longitudinal study. J. Periodontol., 62: 370-376, 1991. – reference: 三木靖夫, 大竹 毅, 島袋善夫, 北村正博, 島内英俊, 村上伸也, 岡田, 宏: 長期経過症例における歯周病ハイリスク患者の検討. 日歯周誌35: 409-416, 1993. – reference: Burton, R.: Mechanisms of oral colonization. Slots, J. and Taubman, M.A., Contemporary Oral Microbiology and Immunology, Mosby, St. Louis, 1992, 283-298. – reference: Johnson, N. W., Griffiths, G. S., Wilton, J.M.A., Maiden, M. F. J., Curtis, M. A., Gillett, I. R., Wilson, D.T. and Stern, J. A. C.: Detection of high-risk groups and individuals for periodontal diseases. Evidence for the existence of high-risk groups and individuals and approaches to their detection. J. Clin. Periodontol., 15: 276-282, 1988. – reference: Ebersole J. L., Taubman, M.A., Smith, D. J. and Haffajee, A. D.: Effect of subgingival scaling on systemic antibody responses to oral microorganisms. Infect. Immun. 48: 534-539, 1985. – reference: Haffajee, A. D., Socransky, S. S. and Goodson, J. M.: Comparison of different data analyses for detecting changes in attachment level. J. Clin. Periodontol., 10: 298-310, 1983. – reference: Socransky, S. S., Haffajee, A. D., Goodson, J. M. and Lindhe, j.: New concepts of destructive periodontal disease. J. Clin. Periodontol., 11: 21-32, 1984. – reference: Goodson, J. M., Tanner, A. C. R., Haffajee, A. D., Sornberger, G. C. and Socransky, S. S.: Patterns and proregression of advanced destructive periodontal disease. J. Clin. Periodontol., 9: 472-481, 1982 – reference: Beale, M. G., MacDernoff, R . P., Stacey, M. C., Nash, G.S., Hahn, B. H., Seiden, M. V., Jacobs S. L. B. and Lowenstein, S. P.: Stimulating cell types in the autologous mixed leukocyte reaction in man. J. Immunol., 124: 227-232, 1980. – reference: Haffajee, A. D., Socransky, S. S. and Goodson, J. M.: Clinical parameters as predictors of destructive periodontal disease activity. J. Clin. Periodontol., 10: 257-265, 1983. – reference: 神山 章: 歯周病の診断に関する細菌学的研究. 日歯周誌, 31: 360-379, 1989. – reference: Greenstein G., Caton, J.G. and Polson, A. M.: Histologic characteristic associated with bleeding after probing and visual signs of inflammations. J. Periodontol., 52: 420-425, 1981. – reference: Slots, J. and Listgarten M. A.: Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in human periodontal diseases. J. Clin. Periodontol. 15: 85-93, 1988. – reference: Curtis, M. A., Gillett, I. R., Griffiths, G. S., Maiden M. F. J., Sterne, J. A. C., Wilson, D. T. and Johnson, N. W.: Detection of high-risk groups and individuals for periodontal diseases. Laboratory markers from analysis of gingival crevicular fluid. J. Clin. Periodontol., 16: 1-11, 1989. – reference: Cooper, P. G., Caton J. G. and Polson A. M.: Cell populations associated with gingival bleeding. J. Periodontol., 54: 497-502, 1983. – reference: Akbar, A. N., Salmon, M. and Janosgy, G.: The synergy between naive and memory T cells during activation. Immunology today 12: 184-188, 1991. – reference: Socransky, S. S.: Microbiology of Periodontal disease. Present status and future consideration. J. Periodontol., 48: 497-504, 1977. – reference: Albandar, J.M., Rise, J., Gjermo, P. and Johansen, J.R.: Radiographic quantification of alveolar bone level changes. A 2-year longitudinal study in man. J. Clin. Periodontol., 13: 195-200, 1986. – reference: Wilton, J. M. A., Griffiths, G. S., Curtis, M. A., Maiden, M. F. J., Gilltt, I. R., Wilson, D. T., Sterne, J. A. C. and Johnson, N. W.: Detection of high-risk groups and individuals for periodontal diseases. Systemic predisposition and markers of general health. J. Clin, Periodontol., 15: 339-346, 1988. – reference: Griffiths, G. S., Wilton, J. M. A., Curtis, M. A., Maiden, M. F. J., Gillett, I. R., Wilson, D. T., Sterne. J. A. C. and Johnson, N. W.: Detection of high-risk groups and individuals for periodontal diseases. Clinical assessment of the periodontium. J. Clin Periodontol., 15: 403-410, 1988. – reference: Silness, J. and Loe, H.: Periodontal disease in pregnancy, II. Correlation between oral hygiene and periodontal condition. Acta Odont. Scand., 22: 121-135, 1964. – reference: Haffajee, A. D., Socransky, S. S. and Goodson, J. M.: Periodontal disease activity. J. Periodont. Res., 17: 521-522, 1982. |
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| Snippet | 長期間メインテナンスを受けている患者群において歯周病ハイリスク患者を選別し, 細菌学的ならびに免疫学的検討を行った。被験者は初期治療終了後の再評価から5年以... 長期間メインテナンスを受けている患者群において歯周病ハイリスク患者を選別し, 細菌学的ならびに免疫学的検討を行った. 被験者は初期治療終了後の再評価から5年以... |
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| Title | 歯周病ハイリスク患者における宿主応答の解析 |
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| ispartofPNX | 日本歯周病学会会誌, 1994/12/28, Vol.36(4), pp.857-870 |
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