Oral protein loading tests in patients with renal impairment
We investigated the usefulness of oral protein loading tests for evaluating renal functional reserve. Healthy subjects and patients with renal impairment were given protein-rich meals to eat after a night's fast (1 g protein/kg body weight). Later, at hougly intervals, the creatinine clearance...
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| Published in | Nihon Jinzo Gakkai shi Vol. 30; no. 9; pp. 1091 - 1094 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Japanese Society of Nephrology
01.09.1988
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-2385 1884-0728 |
| DOI | 10.14842/jpnjnephrol1959.30.1091 |
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| Abstract | We investigated the usefulness of oral protein loading tests for evaluating renal functional reserve. Healthy subjects and patients with renal impairment were given protein-rich meals to eat after a night's fast (1 g protein/kg body weight). Later, at hougly intervals, the creatinine clearance (Ccr) was measured and the change compared to the previous value (delta Ccr) was estimated. Boiled lean yellowfin tuna was used as the protein source. The largest delta Ccr in the healthy subjects, 34.4 ± 6.0 ml/min, occurred at the second hour after the protein load. There was a significant correlation between the delta Ccr values and the preceding Ccr values. On the basis of these results, the delta Ccr after oral protein loading was considered to reflect the renal functional reserve, and monitoring of delta Ccr appeared to be useful for evaluating the progression of renal impairment. |
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| AbstractList | We investigated the usefulness of oral protein loading tests for evaluating renal functional reserve. Healthy subjects and patients with renal impairment were given protein-rich meals to eat after a night's fast (1 g protein/kg body weight). Later, at hougly intervals, the creatinine clearance (Ccr) was measured and the change compared to the previous value (delta Ccr) was estimated. Boiled lean yellowfin tuna was used as the protein source. The largest delta Ccr in the healthy subjects, 34.4 ± 6.0 ml/min, occurred at the second hour after the protein load. There was a significant correlation between the delta Ccr values and the preceding Ccr values. On the basis of these results, the delta Ccr after oral protein loading was considered to reflect the renal functional reserve, and monitoring of delta Ccr appeared to be useful for evaluating the progression of renal impairment. |
| Author | OIMOMI, MUNETADA NAKAMICHI, TSUNEO NISHIMOTO, SHIGEKI BABA, SHIGEAKI HATA, FUMIHIKO MATSUMOTO, SHINICHIRO MAEDA, YUICHIRO IGAKI, NAOYA KITAMURA, YOSHIAKI MASUDA, SHOGO HATANAKA, HIROSHI |
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| References | 6. Bosch JP, Saccaggi A, Lauer A, Ronco C, Belledonne M, Glabman S: Renal functional reserve in humans: Effect of protein intake on glomerular filtration rate. Am J Med 75: 943-950, 1983 9. Jones G, Lee K, Swaminathan R: Glomerular filtration response to acute protein load. Lancet 11: 838, 1985 14. O'Connor WJ, Summerill RA: Sulphate excretion by dogs following ingestion of ammonium sulphate or meat. J Physiol 260: 597-607, 1976 2. Hiatt EP, Hiatt RB: The effect of food on the glomerular filtration rate and renal blood flow in the harbor seal (Phoca vitulina L.). J Cell Comp Physiol 19: 221-227, 1942 4. Reinhardt HW, Kaczmarczyk G, Fahrenhorst K, Blendinger I, Gatzka M, Kuhl U, Riedel J: Post prandial changes of renal blood flow: Studies on conscious dogs on a high and low sodium intake. Pflügers Arch 354: 287-297, 1975 5. Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidne disease: The role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med 307: 652-659, 1982 1. Shannon JA, Jolliffe N, Smith HW: The excretion of urine in the dog. IV. The effect of maintenance diet, feeding, etc., upon the quantity of glomerular filtrate. Am J Physiol 101: 625-638, 1932 12. Maarck T, Johnson V, Tate SS, Meister A: Effects of amino-acids (AA) on the function of the isolated perfused rat kidney. Fed Proc 33: 305, 1974 7. Bosch JP, Laure A, Glabman S: Short-term protein loading in assessment of patients with renal disease. Am J Med 77: 873-879, 1984 8. Wee PM, Geerlings W; Rosman JB, Sluiter WJ, Geest S, Donker AJM: Testing renal reserve filtration capacity with an amino acid solution. Nephron 41:193-199, 1985 3. O'Connor WJ, Summerill RA: The effect of a meal of meat on glomerular filtration rate in dogs at normal urine flows. J Physiol 256: 81-91, 1976 11. Rodriguez-Iturbe R, Herrera J, Garcia R: Response to acute protein load in kidney donors and in apparently normal postacute glomerulonephritis patients: Evidence for gomerular hyperfiltration. Lancet II: 461-464,1985 13. O'Connor WJ, Summerill RA: The excretion of urea by dogs following a meal of meat. J Physiol 256: 93-102, 1976 10. Vanrenterghem Y, Verberckmoes R, Roels L, Michielsen P: Glomerular filtration response to acute protein load. Lancet II: 1360, 1985 |
| References_xml | – reference: 1. Shannon JA, Jolliffe N, Smith HW: The excretion of urine in the dog. IV. The effect of maintenance diet, feeding, etc., upon the quantity of glomerular filtrate. Am J Physiol 101: 625-638, 1932 – reference: 10. Vanrenterghem Y, Verberckmoes R, Roels L, Michielsen P: Glomerular filtration response to acute protein load. Lancet II: 1360, 1985 – reference: 3. O'Connor WJ, Summerill RA: The effect of a meal of meat on glomerular filtration rate in dogs at normal urine flows. J Physiol 256: 81-91, 1976 – reference: 7. Bosch JP, Laure A, Glabman S: Short-term protein loading in assessment of patients with renal disease. Am J Med 77: 873-879, 1984 – reference: 6. Bosch JP, Saccaggi A, Lauer A, Ronco C, Belledonne M, Glabman S: Renal functional reserve in humans: Effect of protein intake on glomerular filtration rate. Am J Med 75: 943-950, 1983 – reference: 2. Hiatt EP, Hiatt RB: The effect of food on the glomerular filtration rate and renal blood flow in the harbor seal (Phoca vitulina L.). J Cell Comp Physiol 19: 221-227, 1942 – reference: 12. Maarck T, Johnson V, Tate SS, Meister A: Effects of amino-acids (AA) on the function of the isolated perfused rat kidney. Fed Proc 33: 305, 1974 – reference: 8. Wee PM, Geerlings W; Rosman JB, Sluiter WJ, Geest S, Donker AJM: Testing renal reserve filtration capacity with an amino acid solution. Nephron 41:193-199, 1985 – reference: 13. O'Connor WJ, Summerill RA: The excretion of urea by dogs following a meal of meat. J Physiol 256: 93-102, 1976 – reference: 11. Rodriguez-Iturbe R, Herrera J, Garcia R: Response to acute protein load in kidney donors and in apparently normal postacute glomerulonephritis patients: Evidence for gomerular hyperfiltration. Lancet II: 461-464,1985 – reference: 5. Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidne disease: The role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med 307: 652-659, 1982 – reference: 9. Jones G, Lee K, Swaminathan R: Glomerular filtration response to acute protein load. Lancet 11: 838, 1985 – reference: 4. Reinhardt HW, Kaczmarczyk G, Fahrenhorst K, Blendinger I, Gatzka M, Kuhl U, Riedel J: Post prandial changes of renal blood flow: Studies on conscious dogs on a high and low sodium intake. Pflügers Arch 354: 287-297, 1975 – reference: 14. O'Connor WJ, Summerill RA: Sulphate excretion by dogs following ingestion of ammonium sulphate or meat. J Physiol 260: 597-607, 1976 |
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| SubjectTerms | Adult Aged Animals Creatinine - blood Creatinine - urine Dietary Proteins - metabolism Dietary Proteins - pharmacology Female Glomerular filtration rate Glomerular Filtration Rate - drug effects Humans Hyperfiltration Kidney Diseases - metabolism Kidney Diseases - physiopathology Kidney Function Tests - methods Male Middle Aged Protein loading test Renal function Renal impairment Tuna |
| Title | Oral protein loading tests in patients with renal impairment |
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