Oral protein loading tests in patients with renal impairment

• Published in: Nihon Jinzo Gakkai shi Vol. 30; no. 9; pp. 1091 - 1094
• Main Authors: KITAMURA, YOSHIAKI, OIMOMI, MUNETADA, HATANAKA, HIROSHI, MAEDA, YUICHIRO, BABA, SHIGEAKI, IGAKI, NAOYA, MATSUMOTO, SHINICHIRO, NISHIMOTO, SHIGEKI, MASUDA, SHOGO, NAKAMICHI, TSUNEO, HATA, FUMIHIKO
• Format: Journal Article
• Language: English
• Published: Japan Japanese Society of Nephrology 01.09.1988
• Subjects: Adult; Aged; Animals; Creatinine - blood; Creatinine - urine; Dietary Proteins - metabolism; Dietary Proteins - pharmacology; Female; Glomerular filtration rate; Glomerular Filtration Rate - drug effects; Humans; Hyperfiltration; Kidney Diseases - metabolism; Kidney Diseases - physiopathology; Kidney Function Tests - methods; Male; Middle Aged; Protein loading test; Renal function; Renal impairment; Tuna
• ISSN: 0385-2385; 1884-0728
• DOI: 10.14842/jpnjnephrol1959.30.1091

We investigated the usefulness of oral protein loading tests for evaluating renal functional reserve. Healthy subjects and patients with renal impairment were given protein-rich meals to eat after a night's fast (1 g protein/kg body weight). Later, at hougly intervals, the creatinine clearance (Ccr) was measured and the change compared to the previous value (delta Ccr) was estimated. Boiled lean yellowfin tuna was used as the protein source. The largest delta Ccr in the healthy subjects, 34.4 ± 6.0 ml/min, occurred at the second hour after the protein load. There was a significant correlation between the delta Ccr values and the preceding Ccr values. On the basis of these results, the delta Ccr after oral protein loading was considered to reflect the renal functional reserve, and monitoring of delta Ccr appeared to be useful for evaluating the progression of renal impairment.