口腔・中咽頭・下咽頭癌における重複癌
口腔癌984例, 中咽頭癌214例, および下咽頭・頸部食道癌408例を対象とし, 重複癌に関する調査を行った.その結果,(1) 第1癌診断後5年間に5.2%, 10年間に10.5%の頭頸部重複癌発生を認めた.(2) 頭頸部, 食道, 胃, および肺に発生する重複癌が全重複癌の約80%を占め, 重複癌の好発部位と考えられた.(3) 頭頸部重複癌発生に関与する因子として, 第1癌の原発部位, 飲酒量, 白斑の有無, 初回治療年度, Stage分類があげられた.重複癌の好発部位や発生に関与する因子を考慮しつつ重複癌の早期発見に努めること, 可及的にすべての癌病変の根治をめざすこと, 禁酒・禁煙が,...
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| Published in | Stomato-pharyngology Vol. 12; no. 3; pp. 349 - 360 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本口腔・咽頭科学会
2000
Japan Society of Stomato-pharyngology |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0917-5105 1884-4316 |
| DOI | 10.14821/stomatopharyngology1989.12.349 |
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| Abstract | 口腔癌984例, 中咽頭癌214例, および下咽頭・頸部食道癌408例を対象とし, 重複癌に関する調査を行った.その結果,(1) 第1癌診断後5年間に5.2%, 10年間に10.5%の頭頸部重複癌発生を認めた.(2) 頭頸部, 食道, 胃, および肺に発生する重複癌が全重複癌の約80%を占め, 重複癌の好発部位と考えられた.(3) 頭頸部重複癌発生に関与する因子として, 第1癌の原発部位, 飲酒量, 白斑の有無, 初回治療年度, Stage分類があげられた.重複癌の好発部位や発生に関与する因子を考慮しつつ重複癌の早期発見に努めること, 可及的にすべての癌病変の根治をめざすこと, 禁酒・禁煙が, 現時点で可能な重複癌対策であると考えられた. |
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| AbstractList | 口腔癌984例, 中咽頭癌214例, および下咽頭・頸部食道癌408例を対象とし, 重複癌に関する調査を行った.その結果,(1) 第1癌診断後5年間に5.2%, 10年間に10.5%の頭頸部重複癌発生を認めた.(2) 頭頸部, 食道, 胃, および肺に発生する重複癌が全重複癌の約80%を占め, 重複癌の好発部位と考えられた.(3) 頭頸部重複癌発生に関与する因子として, 第1癌の原発部位, 飲酒量, 白斑の有無, 初回治療年度, Stage分類があげられた.重複癌の好発部位や発生に関与する因子を考慮しつつ重複癌の早期発見に努めること, 可及的にすべての癌病変の根治をめざすこと, 禁酒・禁煙が, 現時点で可能な重複癌対策であると考えられた. Objective: To clarify the incidence, timing, and sites of multiple primary neoplasms (MPNs) and to analyze contributing factors in their development in patients with squamous cell carcinoma (SCC) of the head and neck.Setting: Specialized cancer center.Subjects: Subjects consisted of the following three groups of patients with previously untreated SCC of the head and neck: 1) OC group: 984 patients with carcinoma of the oral cavity; (2) MP group: 214 patients with carcinoma of the mesopharynx; and (3) HP group: 408 patients with carcinoma of the hypopharynx and cervical esophagus.Methods: Clinical charts of the patients were retrospectively reviewed for MPN development. Because this paper is directed mainly to otolaryngologists, MPNs developing in the head and neck area (HNMPNs) were analyzed independently.Results: (1) The 5-year and 10-year cumulative incidence rates of HNMPNs were 5.2% and 10.5 %, respectively. The 5-year and 10-year cumulative incidence rates of all MPNs were 13.1% and 22.1 %, respectively.(2) Synchronous HNMPNs accounted for 15.9%, 13.8%, and 81.3% of all HNMPNs in the OC, MP, and HP groups, respectively.(3) HNMPNs and MPNs developing in the esophagus, stomach, and lungs accounted for approximately 80% of all MPNs in each group.(4) A significantly high development of HNMPNs was observed in the oral cavity and pharynx in the OC group, the oral cavity and pharynx, and larynx in the MP group, the oral cavity and pharynx, thyroid, and larynx in the HP group.(5) Significant contributing factors in HNMPN development included the primary site of the index cancer, alcohol intake, presence or absence of leukoplakia, year of first treatment, and UICC stage classification.Conclusions: These results provide a solid basis for the necessity of regular and repeated examinations of high-risk areas, i.e. the head and neck, esophagus, stomach, and lungs, to achieve an early diagnosis of MPNs. 口腔癌984例, 中咽頭癌214例, および下咽頭・頸部食道癌408例を対象とし, 重複癌に関する調査を行った.その結果,(1) 第1癌診断後5年間に5.2%, 10年間に10.5%の頭頸部重複癌発生を認めた.(2) 頭頸部, 食道, 胃, および肺に発生する重複癌が全重複癌の約80%を占め, 重複癌の好発部位と考えられた.(3) 頭頸部重複癌発生に関与する因子として, 第1癌の原発部位, 飲酒量, 白斑の有無, 初回治療年度, Stage分類があげられた.重複癌の好発部位や発生に関与する因子を考慮しつつ重複癌の早期発見に努めること, 可及的にすべての癌病変の根治をめざすこと, 禁酒・禁煙が, 現時点で可能な重複癌対策であると考えられた. |
| Author | 斉川, 雅久 海老原, 敏 |
| Author_FL | 海老原 敏 斉川 雅久 |
| Author_FL_xml | – sequence: 1 fullname: 斉川 雅久 – sequence: 2 fullname: 海老原 敏 |
| Author_xml | – sequence: 1 fullname: 海老原, 敏 organization: 国立がんセンター東病院頭頸科 – sequence: 1 fullname: 斉川, 雅久 organization: 国立がんセンター東病院頭頸科 |
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| References | 3) Saikawa M, Ebihara S, Yoshizumi T et al: Multiple primary cancers in patients with squamous cell carcinoma of the oral cavity. Jpn J Cancer Res 82: 40-45, 1991. 1) Gluckman JL, Crissman JD: Survival rates in 548 patients with multiple neoplasms of the upper aerodigestive tract. Laryngoscope 93: 71-74, 1983. 5) Schoenberg BS, Myers MH: Statistical methods for studying multiple primary malignant neoplasms. Cancer 40: 1892-1898, 1977. 6) The Research Group for Population-based Cancer Registration in Japan: Cancer incidence in Japan, 1975-cancer registry statistics. Gann Monogr Cancer Res 26: 92-116, 1981. 11) Takezaki T, Hirose K, Inoue M et al: Tobacco, alcohol and dietary factors associated with the risk of oral cancer among Japanese. Jpn J Cancer Res 87: 555-562, 1996. 4) Warren S, Gates O: Multiple primary malignant tumors. A survey of the literature and a statistical study. Am J Cancer 16: 1358-1414, 1932. 8) 日本頭頸部腫瘍学会 (編): 頭頸部癌取扱い規約 (第2版). 金原出版, 東京, 1991, 57頁. 9) 斉川雅久: 同時多重がん治療上の問題点―口腔癌・中咽頭癌における治療方針―. 頭頸部腫瘍 19: 330-336, 1993. 2) 斉川雅久: 頭頸部多重癌の予後を改善する方策. JOHNS 13: 1281-1285, 1997. 7) The Research Group for Population-based Cancer Registration in Japan: Cancer incidence and incidence rates in Japan in 1985-estimates based on data from seven population-based cancer registries. Jpn J Clin Oncol 20: 212-218, 1990. 10) Hong WK, Lippman SM, Itri LM et al: Prevention of second primary tumors with isotretinoin in squamouscell carcinoma of the head and neck. N Engl J Med 323: 795-801, 1990. |
| References_xml | – reference: 10) Hong WK, Lippman SM, Itri LM et al: Prevention of second primary tumors with isotretinoin in squamouscell carcinoma of the head and neck. N Engl J Med 323: 795-801, 1990. – reference: 1) Gluckman JL, Crissman JD: Survival rates in 548 patients with multiple neoplasms of the upper aerodigestive tract. Laryngoscope 93: 71-74, 1983. – reference: 4) Warren S, Gates O: Multiple primary malignant tumors. A survey of the literature and a statistical study. Am J Cancer 16: 1358-1414, 1932. – reference: 6) The Research Group for Population-based Cancer Registration in Japan: Cancer incidence in Japan, 1975-cancer registry statistics. Gann Monogr Cancer Res 26: 92-116, 1981. – reference: 7) The Research Group for Population-based Cancer Registration in Japan: Cancer incidence and incidence rates in Japan in 1985-estimates based on data from seven population-based cancer registries. Jpn J Clin Oncol 20: 212-218, 1990. – reference: 2) 斉川雅久: 頭頸部多重癌の予後を改善する方策. JOHNS 13: 1281-1285, 1997. – reference: 8) 日本頭頸部腫瘍学会 (編): 頭頸部癌取扱い規約 (第2版). 金原出版, 東京, 1991, 57頁. – reference: 3) Saikawa M, Ebihara S, Yoshizumi T et al: Multiple primary cancers in patients with squamous cell carcinoma of the oral cavity. Jpn J Cancer Res 82: 40-45, 1991. – reference: 5) Schoenberg BS, Myers MH: Statistical methods for studying multiple primary malignant neoplasms. Cancer 40: 1892-1898, 1977. – reference: 9) 斉川雅久: 同時多重がん治療上の問題点―口腔癌・中咽頭癌における治療方針―. 頭頸部腫瘍 19: 330-336, 1993. – reference: 11) Takezaki T, Hirose K, Inoue M et al: Tobacco, alcohol and dietary factors associated with the risk of oral cancer among Japanese. Jpn J Cancer Res 87: 555-562, 1996. |
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| SubjectTerms | hypopharyngeal cancer mesopharyngeal cancer multiple primary neoplasms oral cavity cancer squamous cell carcinoma 下咽頭癌 中咽頭癌 口腔癌 扁平上皮癌 重複癌 |
| Title | 口腔・中咽頭・下咽頭癌における重複癌 |
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