Rituximab併用化学療法に反応したMALTリンパ腫関連クリオグロブリン陽性膜性増殖性糸球体腎炎の1例
症例は61歳，男性．胃原発mucosa associated lymphoid tissue（MALT）リンパ腫の切除後の再発時にネフローゼ症候群を発症しクリオグロブリン陽性の膜性増殖性糸球体腎炎（MPGN）+半月体形成性糸球体腎炎の診断を得た．腎不全進行により透析療法を開始したがRituximabを含めた多剤化学療法を行ったところ，MALTの退縮と同時に腎機能の回復が得られ，透析離脱が可能となった．本症例のMPGN発症機序として腫瘍B細胞が深く関わっていた可能性が示唆された．...
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| Published in | 日本内科学会雑誌 Vol. 100; no. 4; pp. 1054 - 1057 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本内科学会
2011
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5384 1883-2083 |
| DOI | 10.2169/naika.100.1054 |
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| Abstract | 症例は61歳，男性．胃原発mucosa associated lymphoid tissue（MALT）リンパ腫の切除後の再発時にネフローゼ症候群を発症しクリオグロブリン陽性の膜性増殖性糸球体腎炎（MPGN）+半月体形成性糸球体腎炎の診断を得た．腎不全進行により透析療法を開始したがRituximabを含めた多剤化学療法を行ったところ，MALTの退縮と同時に腎機能の回復が得られ，透析離脱が可能となった．本症例のMPGN発症機序として腫瘍B細胞が深く関わっていた可能性が示唆された． |
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| AbstractList | 症例は61歳，男性．胃原発mucosa associated lymphoid tissue（MALT）リンパ腫の切除後の再発時にネフローゼ症候群を発症しクリオグロブリン陽性の膜性増殖性糸球体腎炎（MPGN）+半月体形成性糸球体腎炎の診断を得た．腎不全進行により透析療法を開始したがRituximabを含めた多剤化学療法を行ったところ，MALTの退縮と同時に腎機能の回復が得られ，透析離脱が可能となった．本症例のMPGN発症機序として腫瘍B細胞が深く関わっていた可能性が示唆された． |
| Author | 横尾, 隆 宮崎, 陽一 早川, 洋 倉重, 眞大 坪井, 伸夫 宇都宮, 保典 細谷, 龍男 |
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| References | 4) Stokes MB, et al: Membranoproliferative glomerulonephritis associated with low-grade B cell lymphoma presenting in the kidney. Clin nephrol 57: 303-309, 2002. 3) Dunn P, et al: Primary salivary gland lymphoma: a clinicopathologic study of 23 cases in Taiwan. Acta Haematol 112: 203-208, 2004. 1) Mallouk A, et al: Concurrent FSGS and Hodgkin's lymphoma: case report and literature review on the link between nephrotic glomerulopathies and hematological malignancies. Clin Exp Nephrol 10: 284-289, 2006. 2) Buob D, et al: Mixed cryoglobulinemia-associated membranoproliferative glomerulonephritis, disclosing gastric MALT lymphoma. Ann Pathol 26: 267-270, 2006. 5) Almehmi A, et al: Cryoglobulinemic glomerulopathy complicating Helicobacter pyloli-associated gastric mucosa-associated lymphoid tissue lymphoma. Am J Kidney Dis 54: 770-774, 2009. |
| References_xml | – reference: 2) Buob D, et al: Mixed cryoglobulinemia-associated membranoproliferative glomerulonephritis, disclosing gastric MALT lymphoma. Ann Pathol 26: 267-270, 2006. – reference: 1) Mallouk A, et al: Concurrent FSGS and Hodgkin's lymphoma: case report and literature review on the link between nephrotic glomerulopathies and hematological malignancies. Clin Exp Nephrol 10: 284-289, 2006. – reference: 3) Dunn P, et al: Primary salivary gland lymphoma: a clinicopathologic study of 23 cases in Taiwan. Acta Haematol 112: 203-208, 2004. – reference: 4) Stokes MB, et al: Membranoproliferative glomerulonephritis associated with low-grade B cell lymphoma presenting in the kidney. Clin nephrol 57: 303-309, 2002. – reference: 5) Almehmi A, et al: Cryoglobulinemic glomerulopathy complicating Helicobacter pyloli-associated gastric mucosa-associated lymphoid tissue lymphoma. Am J Kidney Dis 54: 770-774, 2009. |
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| Snippet | 症例は61歳，男性．胃原発mucosa associated lymphoid tissue（MALT）リンパ腫の切除後の再発時にネフローゼ症候群を発症しクリオグロブリン陽性の膜性増殖性糸球体腎... |
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| SubjectTerms | MALTリンパ腫 Rituximab 膜性増殖性糸球体腎炎（MPGN） |
| Title | Rituximab併用化学療法に反応したMALTリンパ腫関連クリオグロブリン陽性膜性増殖性糸球体腎炎の1例 |
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