Invasive micropapillary carcinoma成分を伴ったS状結腸癌の1例

症例は48歳，女性．血便を主訴に近医を受診し，下部消化管内視鏡検査でS状結腸に2型腫瘍を認めた．生検で高分化型腺癌と診断され，当院に紹介受診となった．腹部CT検査で，肝S4に径3cmの腫瘤を認め，同時性肝転移と診断した．手術はS状結腸切除術および肝左葉切除術を施行した．病理組織学的所見でS状結腸癌の浸潤部にinvasive micropapillary carcinoma（IMPC）成分を認めた．IMPCはSiraunkgulらが1993年に提唱した浸潤性乳癌の新しい組織型であり，近年，他臓器での報告も認められるようになってきた．IMPC成分を有する大腸癌の報告は比較的稀であり，文献的考察を加...

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Published in日本臨床外科学会雑誌 Vol. 74; no. 8; pp. 2234 - 2238
Main Authors 鈴村, 潔, 田島, 将吾, 寺崎, 正起, 神谷, 忠宏, 岡本, 好史, 加藤, 健宏
Format Journal Article
LanguageJapanese
Published 日本臨床外科学会 2013
Subjects
大腸癌
微小乳頭癌
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ISSN1345-2843
1882-5133
DOI10.3919/jjsa.74.2234

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Abstract 症例は48歳，女性．血便を主訴に近医を受診し，下部消化管内視鏡検査でS状結腸に2型腫瘍を認めた．生検で高分化型腺癌と診断され，当院に紹介受診となった．腹部CT検査で，肝S4に径3cmの腫瘤を認め，同時性肝転移と診断した．手術はS状結腸切除術および肝左葉切除術を施行した．病理組織学的所見でS状結腸癌の浸潤部にinvasive micropapillary carcinoma（IMPC）成分を認めた．IMPCはSiraunkgulらが1993年に提唱した浸潤性乳癌の新しい組織型であり，近年，他臓器での報告も認められるようになってきた．IMPC成分を有する大腸癌の報告は比較的稀であり，文献的考察を加え報告する．
AbstractList 症例は48歳，女性．血便を主訴に近医を受診し，下部消化管内視鏡検査でS状結腸に2型腫瘍を認めた．生検で高分化型腺癌と診断され，当院に紹介受診となった．腹部CT検査で，肝S4に径3cmの腫瘤を認め，同時性肝転移と診断した．手術はS状結腸切除術および肝左葉切除術を施行した．病理組織学的所見でS状結腸癌の浸潤部にinvasive micropapillary carcinoma（IMPC）成分を認めた．IMPCはSiraunkgulらが1993年に提唱した浸潤性乳癌の新しい組織型であり，近年，他臓器での報告も認められるようになってきた．IMPC成分を有する大腸癌の報告は比較的稀であり，文献的考察を加え報告する．
Author 神谷, 忠宏
寺崎, 正起
岡本, 好史
加藤, 健宏
田島, 将吾
鈴村, 潔
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References 6) 鮫島直樹，佐藤勇一郎，柴田伸弘他:Invasive micropapillary carcinoma成分を伴った原発性大腸癌の1例．診断病理　2007;24:236-239
4) Nassar H, Pansare V, Zhang H, et al : Pathogenesis of invasive micropapillary carcinoma : role of MUC1 glycoprotein. Mod Pathol 2004 ; 17 : 1045-1050
8) 竹下雅樹，鎌田　徹，大場　大他:リンパ節転移，漿膜下浸潤をきたしたmicropapillary patternを呈する早期癌類似進行直腸癌の1例．日臨外会誌　2009;70:470-474
9) Hisamori S, Nagayama S, Kita S, et al : Rapid progression of submucosal invasive micropapillary carcinoma of the colon in progressive systemic sclerosis : report of a case. Jpn J Clin Oncol 2009 ; 39 : 399-405
14) Makimoto Y, Nabeshima K, Iwasaki H, et al : Micropapillary pattern : a distinct pathological marker to subclassify tumours with a significantly poor prognosis within small peripheral lung adenocarcinoma (</=20 mm) with mixed bronchioloalveolar and invasive subtypes (Noguchi's type C tumours). Histopathology 2005 ; 46 : 677-684
1) Siriaunkgul S, Tavassoli FA : Invasive micropapillary carcinoma of the breast. Mod Pathol 1993 ; 6 : 660-662
5) 上田貴威，加島健司，駄阿　勉他:Micropapillary carcinoma成分を伴う大腸癌の2例．診断病理　2006;23:217-221
11) 松崎晶子，河内由布子，新垣淳也他:Micropapillary carcinoma成分を伴う早期大腸癌の1例．診断病理　2009;26:242-244
12) 西島弘二，宮下知治，二上文夫他:術後2年目に肺転移再発をきたした腺腫内に発生したmicropapillary carcinoma成分を有する直腸早期癌の1例．日本大腸肛門病会誌　2010;63:201-205
15) Nagao T, Gaffey TA, Visscher D, et al : Invasive papillary salivary duct carcinoma : a distinct variant with biologic significance. Am J Surg Pathol 2004 ; 28 : 319-326
16) 津曲幸二，坂元吾偉，秋山　太他:乳腺のInvasive micropapillary carcinomaの病理診断と臨床的意義．乳癌の臨　2005;16:441-447
17) Kim MJ, Hong SM, Jang SJ, et al : Invasive colorectal micropapillary carcinoma : an aggressive variant of adenocarcinoma. Hum Pathol 2006 ; 37 : 809-815
2) Ellis IO, Schnitt SJ, Sastre-Garau X, et al : Invasive ductal carcinoma. In : Tavassoli FA, Devilee P, WHO Classification of Tumours : Pathology and Genetics, Tumours of the breast and Female Genital Organs, IARC Press, Lyon, 2003, p35-36
13) 富岡寛行，斉藤修治，絹笠祐介他:Micropapillary Carcinoma成分を含んだ直腸癌の1例．臨外　2011;66:697-700
19) Xu F, Xu J, Lou Z, et al : Micropapillary component in colorectal carcinoma is associated with lymph node metastasis in T1 and T2 stages and decreased survival time in TNM stages I and II. Am J Surg Pathol 2009 ; 33 : 1287-1292
10) Sonoo H, Kameyama M, Inatugi N, et al : Pedunculated polyp of early sigmoid colon cancer with invasive micropapillary carcinoma. Jpn J Clin Oncol 2009 ; 39 : 523-527
3) Sakamoto K, Watanabe M, Cruz CDL, et al : Primary invasive micropapillary carcinoma of the colon. Histopathology 2005 ; 47 : 479-484
18) Haupt B, Ro JY, Schwartz MR, et al : Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis. Mod Pathol 2007 ; 20 : 729-733
7) 廣田政志，山下克也，市原　透他:Micropapillary carcinoma成分を伴った直腸癌の1例．日消外会誌　2008;41:1741-1745
References_xml – reference: 6) 鮫島直樹，佐藤勇一郎，柴田伸弘他:Invasive micropapillary carcinoma成分を伴った原発性大腸癌の1例．診断病理　2007;24:236-239
– reference: 7) 廣田政志，山下克也，市原　透他:Micropapillary carcinoma成分を伴った直腸癌の1例．日消外会誌　2008;41:1741-1745
– reference: 11) 松崎晶子，河内由布子，新垣淳也他:Micropapillary carcinoma成分を伴う早期大腸癌の1例．診断病理　2009;26:242-244
– reference: 16) 津曲幸二，坂元吾偉，秋山　太他:乳腺のInvasive micropapillary carcinomaの病理診断と臨床的意義．乳癌の臨　2005;16:441-447
– reference: 13) 富岡寛行，斉藤修治，絹笠祐介他:Micropapillary Carcinoma成分を含んだ直腸癌の1例．臨外　2011;66:697-700
– reference: 17) Kim MJ, Hong SM, Jang SJ, et al : Invasive colorectal micropapillary carcinoma : an aggressive variant of adenocarcinoma. Hum Pathol 2006 ; 37 : 809-815
– reference: 9) Hisamori S, Nagayama S, Kita S, et al : Rapid progression of submucosal invasive micropapillary carcinoma of the colon in progressive systemic sclerosis : report of a case. Jpn J Clin Oncol 2009 ; 39 : 399-405
– reference: 3) Sakamoto K, Watanabe M, Cruz CDL, et al : Primary invasive micropapillary carcinoma of the colon. Histopathology 2005 ; 47 : 479-484
– reference: 5) 上田貴威，加島健司，駄阿　勉他:Micropapillary carcinoma成分を伴う大腸癌の2例．診断病理　2006;23:217-221
– reference: 10) Sonoo H, Kameyama M, Inatugi N, et al : Pedunculated polyp of early sigmoid colon cancer with invasive micropapillary carcinoma. Jpn J Clin Oncol 2009 ; 39 : 523-527
– reference: 18) Haupt B, Ro JY, Schwartz MR, et al : Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis. Mod Pathol 2007 ; 20 : 729-733
– reference: 14) Makimoto Y, Nabeshima K, Iwasaki H, et al : Micropapillary pattern : a distinct pathological marker to subclassify tumours with a significantly poor prognosis within small peripheral lung adenocarcinoma (</=20 mm) with mixed bronchioloalveolar and invasive subtypes (Noguchi's type C tumours). Histopathology 2005 ; 46 : 677-684
– reference: 4) Nassar H, Pansare V, Zhang H, et al : Pathogenesis of invasive micropapillary carcinoma : role of MUC1 glycoprotein. Mod Pathol 2004 ; 17 : 1045-1050
– reference: 8) 竹下雅樹，鎌田　徹，大場　大他:リンパ節転移，漿膜下浸潤をきたしたmicropapillary patternを呈する早期癌類似進行直腸癌の1例．日臨外会誌　2009;70:470-474
– reference: 19) Xu F, Xu J, Lou Z, et al : Micropapillary component in colorectal carcinoma is associated with lymph node metastasis in T1 and T2 stages and decreased survival time in TNM stages I and II. Am J Surg Pathol 2009 ; 33 : 1287-1292
– reference: 1) Siriaunkgul S, Tavassoli FA : Invasive micropapillary carcinoma of the breast. Mod Pathol 1993 ; 6 : 660-662
– reference: 15) Nagao T, Gaffey TA, Visscher D, et al : Invasive papillary salivary duct carcinoma : a distinct variant with biologic significance. Am J Surg Pathol 2004 ; 28 : 319-326
– reference: 12) 西島弘二，宮下知治，二上文夫他:術後2年目に肺転移再発をきたした腺腫内に発生したmicropapillary carcinoma成分を有する直腸早期癌の1例．日本大腸肛門病会誌　2010;63:201-205
– reference: 2) Ellis IO, Schnitt SJ, Sastre-Garau X, et al : Invasive ductal carcinoma. In : Tavassoli FA, Devilee P, WHO Classification of Tumours : Pathology and Genetics, Tumours of the breast and Female Genital Organs, IARC Press, Lyon, 2003, p35-36
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Snippet 症例は48歳，女性．血便を主訴に近医を受診し，下部消化管内視鏡検査でS状結腸に2型腫瘍を認めた．生検で高分化型腺癌と診断され，当院に紹介受診となった．腹部CT検...
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SubjectTerms 大腸癌
微小乳頭癌
Title Invasive micropapillary carcinoma成分を伴ったS状結腸癌の1例
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