好酸球の広範な肺浸潤により気胸を呈したimatinib耐性化慢性好酸球性白血病の剖検例
近年，FIP1L1/PDGFRα融合遺伝子（FP遺伝子）陽性の慢性好酸球性白血病（chronic eosinophilic leukemia；CEL）に対するimatinib（IM）の有効性が示され，治療成績は著しく改善しているが長期予後には不明な点も多い．今回，我々はIMに耐性化し終末期に自然気胸を併発したCEL症例を経験した．剖検で好酸球の肺胞への高度の浸潤およびその近傍の線維化，気腫化が確認され，CELの進行が肺実質の破壊をきたし気胸の原因となったと推定された．...
Saved in:
| Published in | 日本内科学会雑誌 Vol. 98; no. 4; pp. 862 - 865 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本内科学会
2009
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5384 1883-2083 |
| DOI | 10.2169/naika.98.862 |
Cover
| Abstract | 近年，FIP1L1/PDGFRα融合遺伝子（FP遺伝子）陽性の慢性好酸球性白血病（chronic eosinophilic leukemia；CEL）に対するimatinib（IM）の有効性が示され，治療成績は著しく改善しているが長期予後には不明な点も多い．今回，我々はIMに耐性化し終末期に自然気胸を併発したCEL症例を経験した．剖検で好酸球の肺胞への高度の浸潤およびその近傍の線維化，気腫化が確認され，CELの進行が肺実質の破壊をきたし気胸の原因となったと推定された． |
|---|---|
| AbstractList | 近年，FIP1L1/PDGFRα融合遺伝子（FP遺伝子）陽性の慢性好酸球性白血病（chronic eosinophilic leukemia；CEL）に対するimatinib（IM）の有効性が示され，治療成績は著しく改善しているが長期予後には不明な点も多い．今回，我々はIMに耐性化し終末期に自然気胸を併発したCEL症例を経験した．剖検で好酸球の肺胞への高度の浸潤およびその近傍の線維化，気腫化が確認され，CELの進行が肺実質の破壊をきたし気胸の原因となったと推定された． |
| Author | 土居, 忠 田中, 信悟 藤見, 章仁 佐藤, 康裕 太田, 英敏 岩崎, 沙理 石津, 明洋 蟹沢, 祐司 奥田, 敏徳 黄, 勇澤 |
| Author_xml | – sequence: 1 fullname: 奥田, 敏徳 organization: 王子総合病院消化器科 – sequence: 1 fullname: 岩崎, 沙理 organization: 王子総合病院病理科 – sequence: 1 fullname: 土居, 忠 organization: 王子総合病院消化器科 – sequence: 1 fullname: 蟹沢, 祐司 organization: 王子総合病院血液内科 – sequence: 1 fullname: 石津, 明洋 organization: 王子総合病院病理科 – sequence: 1 fullname: 田中, 信悟 organization: 王子総合病院消化器科 – sequence: 1 fullname: 黄, 勇澤 organization: 札幌医科大学第四内科 – sequence: 1 fullname: 太田, 英敏 organization: 王子総合病院消化器科 – sequence: 1 fullname: 藤見, 章仁 organization: 王子総合病院血液内科 – sequence: 1 fullname: 佐藤, 康裕 organization: 王子総合病院消化器科 |
| BookMark | eNo9kEtLw0AUhQepYK3d-TdSM48kMyuR4gsKbnQdJulEU2vUpBt3TWqhPhbVRYsgiFIRFNSNUAr1z8Q8_Bemvjb3nMvlfhzOLMg5-44AYB7KJQRVtuBwe5eXGC1RFU2BPKQUS0imOAfysoygpGBKZkDR82xDJlhVKMQkDw6j-_Fne5h0W6H_HI1ayctx6D-mwSh-G8bjQeg_hUEnDE7j137aGobBZXTRCf1-6N_Ye7xhO7aRNrtx8yE678Xtu4n542U-uRqnt82k356wT3rx4Prj_WwOTFu87onirxbA1sryZnlNqmysrpeXKlINEU2WFGogjBmpYgwtlQiLZTuzNNmCXDG1qgo5waaKVWEiYXLFokyjAjGFZR_coLgAFn-4Na_Bt4V-4GaJ3SOduw3brAv9uy-dUZ1MRlba_8Xc4a5e4_gLe0eNaw |
| ContentType | Journal Article |
| Copyright | 2009 一般社団法人 日本内科学会 |
| Copyright_xml | – notice: 2009 一般社団法人 日本内科学会 |
| DOI | 10.2169/naika.98.862 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1883-2083 |
| EndPage | 865 |
| ExternalDocumentID | article_naika_98_4_98_862_article_char_ja |
| GroupedDBID | 2WC ALMA_UNASSIGNED_HOLDINGS DIK F5P JSF OK1 RJT ZXP |
| ID | FETCH-LOGICAL-j2470-58b23394d331f64ef9b239f70f1a5c7d61a43c636ec2eca5f8978e2959d33ab83 |
| ISSN | 0021-5384 |
| IngestDate | Wed Sep 03 06:00:15 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 4 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j2470-58b23394d331f64ef9b239f70f1a5c7d61a43c636ec2eca5f8978e2959d33ab83 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/naika/98/4/98_862/_article/-char/ja |
| PageCount | 4 |
| ParticipantIDs | jstage_primary_article_naika_98_4_98_862_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20090000 |
| PublicationDateYYYYMMDD | 2009-01-01 |
| PublicationDate_xml | – year: 2009 text: 20090000 |
| PublicationDecade | 2000 |
| PublicationTitle | 日本内科学会雑誌 |
| PublicationTitleAlternate | 日内会誌 |
| PublicationYear | 2009 |
| Publisher | 一般社団法人 日本内科学会 |
| Publisher_xml | – name: 一般社団法人 日本内科学会 |
| References | 1) 藤見章仁, 他: FIP1L1-PDGFRα融合遺伝子とTCR再構成がみられImatinibにより寛解に至ったLymphomatoid Papulosisを伴う好酸球増多症候群の1例. 内科学会雑誌 96: 2794-2797, 2007. 5) Yellin A, et al: Pneumothorax associated with lymphoma. Am Rev Respir Dis 134: 590-592, 1986. 8) Bobnoff N, et al: Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. Leukemia 19: 286-289, 2005. 7) Cools J, et al: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 gene as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 348: 1201-1214, 2003. 9) Ohnishi H, et al: Chronic eosinophilic leukemia with FIP1L1-PDGFRA fusion and T674I mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy. Br J Haematol 134: 544-549, 2006. 3) Steinhauslin CA, et al: Spontaneous pneumothorax. A complication of lung cancer? Chest 88: 709-713, 1985. 4) O'Connor BM, et al: Spontaneous pneumothorax in small cell lung cancer. Chest 102: 628-629, 1992. 6) Geltner D, et al: Acute lymphocytic leukemia. Its occurrence with hypereosinophilic syndrome and bilateral spontataneous pneumothorax. Arch Intern Med 138: 292-293, 1978. 10) Hingorani SR, et al: Targeting oncogene dependence and resistance. Cancer Cell 3: 414-417, 2003. 2) Dines DE, et al: Malignant pulmonary neoplasms predisposing to spontaneous pneumothorax. Mayo Clin Proc 48: 541-544, 1973. |
| References_xml | – reference: 9) Ohnishi H, et al: Chronic eosinophilic leukemia with FIP1L1-PDGFRA fusion and T674I mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy. Br J Haematol 134: 544-549, 2006. – reference: 6) Geltner D, et al: Acute lymphocytic leukemia. Its occurrence with hypereosinophilic syndrome and bilateral spontataneous pneumothorax. Arch Intern Med 138: 292-293, 1978. – reference: 2) Dines DE, et al: Malignant pulmonary neoplasms predisposing to spontaneous pneumothorax. Mayo Clin Proc 48: 541-544, 1973. – reference: 3) Steinhauslin CA, et al: Spontaneous pneumothorax. A complication of lung cancer? Chest 88: 709-713, 1985. – reference: 1) 藤見章仁, 他: FIP1L1-PDGFRα融合遺伝子とTCR再構成がみられImatinibにより寛解に至ったLymphomatoid Papulosisを伴う好酸球増多症候群の1例. 内科学会雑誌 96: 2794-2797, 2007. – reference: 4) O'Connor BM, et al: Spontaneous pneumothorax in small cell lung cancer. Chest 102: 628-629, 1992. – reference: 5) Yellin A, et al: Pneumothorax associated with lymphoma. Am Rev Respir Dis 134: 590-592, 1986. – reference: 10) Hingorani SR, et al: Targeting oncogene dependence and resistance. Cancer Cell 3: 414-417, 2003. – reference: 8) Bobnoff N, et al: Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. Leukemia 19: 286-289, 2005. – reference: 7) Cools J, et al: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 gene as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 348: 1201-1214, 2003. |
| SSID | ssib043658134 ssj0066765 ssib002821954 ssib005879745 ssib007485360 ssib058493862 ssib000940260 ssib002484664 |
| Score | 1.7955656 |
| Snippet | 近年，FIP1L1/PDGFRα融合遺伝子（FP遺伝子）陽性の慢性好酸球性白血病（chronic eosinophilic leukemia；CEL）に対するimatinib（IM）の有効性が示され，治療成績は著しく... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 862 |
| SubjectTerms | chronic eosinophilic leukemia FIP1L1/PDGFRα imatinib spontaneous pneumothorax |
| Title | 好酸球の広範な肺浸潤により気胸を呈したimatinib耐性化慢性好酸球性白血病の剖検例 |
| URI | https://www.jstage.jst.go.jp/article/naika/98/4/98_862/_article/-char/ja |
| Volume | 98 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本内科学会雑誌, 2009, Vol.98(4), pp.862-865 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1883-2083 dateEnd: 99991231 omitProxy: true ssIdentifier: ssib007485360 issn: 0021-5384 databaseCode: KQ8 dateStart: 19130101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9RAFA-lgngRP_GbHpyTpCYzk-TNMVmzFKGC0EJvS7KbQPdQP2gvnrpbC_XjUD20CIIoFUFBvQilUP-ZuB_-F743SXazoqCFJbzM_N7LvPeSvDfZ-TCM60nKo7QpbRODr2NKfBbNWCSWyWPXVc3UtXhMk5Pn77hzi_L2krM0NR1VRi2trcazzUd_nFdyFK9iGfqVZsn-h2dHQrEAafQvHtHDePwnH7PQYb7DglssVAyQABZ6TFkMBAsFJonMDwkT-LrEY36dgSyrfBYCA061ocuCnN0laf4IE2iCM4CSyMEWU55mF5pLVylO11J2CbY1Jifqy5QZryzHmokGV5AYJHyPmKDGlKtLUCE-UfVX_UYYLFEaA8y3qZBKPMJXbQCquAQqp2oslCwIGQTV5JxqkRGvSESN-TXNqFtFxvNIOWoSWsjVErDZPrVNBboKyKgw-u5cNN_X3EqS1fCG1sJRbF17JmSBqOIDznylCUzywxKPpahjobtbxWMzVS7JpmZqPJ7UmW-NYUCYQBWS0MAapjUlR-jGBDDxAWgcYLSi2mnkOtBW8ciKgbYrqu5rbwSC1CKwj78bRzNmNYhy28Q4mX8HSvK4CSDw0cz3JCoDq4LKC0RWoiQUAbhIuPLNQn6P5dx2aSncFZpJN6tgdsQ0sTp68ew1NKyhoCHpgNhGWUOzFxtt7EId4x4mozRu426lB6IkrapXyVhhYsMFDtyurpjogKeqG0R4EvPdMb8UmNHb4xUXMb1XAtzRinY0ojzfVKWwYT4Xh3S9WdUU8-E29g7LkaU62V04ZZwseqkzfq7caWOqHZ0xjs8X43DOGg967w9_bu4Ptjeyzufewcbgy-Os83HYPeh_2-8f7mWdT1l3K-s-7X_dHW7sZ92XvRdbWWc367wp3wPD9e3--ofe853-5jsiSnlID14dDt-uD3Y3SfaTnf7e6x_fn50zFuvhQm3OLDZvMdtcepbpQMyFULIlhJ26MkkVnqvUs1I7cppey7UjKZqucJMmT5qRk4LyIOHKUcgRxSDOG9Mr91aSC8ZMFGOvL7FaDvdiSf_kR1Grya00sq1EqgguGpAbq3E_X6Gn8c93xaWjs142TuT_LNPn2CvG9OrDteQqdlBW42v6FvsF7OwDpQ |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%A5%BD%E9%85%B8%E7%90%83%E3%81%AE%E5%BA%83%E7%AF%84%E3%81%AA%E8%82%BA%E6%B5%B8%E6%BD%A4%E3%81%AB%E3%82%88%E3%82%8A%E6%B0%97%E8%83%B8%E3%82%92%E5%91%88%E3%81%97%E3%81%9Fimatinib%E8%80%90%E6%80%A7%E5%8C%96%E6%85%A2%E6%80%A7%E5%A5%BD%E9%85%B8%E7%90%83%E6%80%A7%E7%99%BD%E8%A1%80%E7%97%85%E3%81%AE%E5%89%96%E6%A4%9C%E4%BE%8B&rft.jtitle=%E6%97%A5%E6%9C%AC%E5%86%85%E7%A7%91%E5%AD%A6%E4%BC%9A%E9%9B%91%E8%AA%8C&rft.au=%E5%A5%A5%E7%94%B0%2C+%E6%95%8F%E5%BE%B3&rft.au=%E5%B2%A9%E5%B4%8E%2C+%E6%B2%99%E7%90%86&rft.au=%E5%9C%9F%E5%B1%85%2C+%E5%BF%A0&rft.au=%E8%9F%B9%E6%B2%A2%2C+%E7%A5%90%E5%8F%B8&rft.date=2009&rft.pub=%E4%B8%80%E8%88%AC%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E5%86%85%E7%A7%91%E5%AD%A6%E4%BC%9A&rft.issn=0021-5384&rft.eissn=1883-2083&rft.volume=98&rft.issue=4&rft.spage=862&rft.epage=865&rft_id=info:doi/10.2169%2Fnaika.98.862&rft.externalDocID=article_naika_98_4_98_862_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-5384&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-5384&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-5384&client=summon |