CLINICAL EVALUATION OF HAPA-B IN THE SURGICAL FIELD

• Published in: CHEMOTHERAPY Vol. 33; no. Supplement5; pp. 420 - 428
• Main Authors: MATSUNAGA, SEIICHI, YAMANISHI, HIROSHI, TOMITA, KAZUYOSHI, OKUMURA, TAKASHI, TAGUCHI, TETSUO, ITOH, ATSUSHI, OKUYAMA, YASUSHI, YAMAGUCHI, AKIRA, OTA, JUN
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1985; 公益社団法人 日本化学療法学会
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.33.Supplement5_420

HAPA-B, a new semisynthetic aminoglycoside, was employed in the treatment of various infectious diseases encountered in the surgical field, and clinical efficacy of the drug was investigated. HAPA-B was administered to a total of 20 patients. Two hundred mg of HAPA-I3 was administered twice a day for 4-15 days by intramuscular injection. The patients who were subjects of evaluation of the efficacy of HAPA-B consisted of 8 cases of infection of soft tissue, 3 cases of postoperative wound infection, 7 cases of peritonitis or postoperative intraabdominal infection (including perineal dead space infection after Miles' op.) and 2 cases of cholangitis. The clinical results were excellent in 2 patients, good in 12, fair in 2, poor in 4 and the efficacy rate was 70.0%. As side effect drug eruption was found in only one case, but no adverse reactions on clinical laboratory findings attributable to the drug were observed. Therefore, HAPA-B is thought to be a useful drug in the surgical field.