CLINICAL STUDY ON CS-807 IN RESPIRATORY INFECTIONS
A new oral cephem antibiotic, CS-807 was administered to 12 patients with respiratory infections, 10 of outpatients and 2 of inpatients. The drug was given a daily dose of 400mg, b. i. d. in 8 patients, 200mg, b. i. d. in 3 patients, and 300mg, t. i. d. in one patient for 5 to 14 days. The clinical...
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| Published in | CHEMOTHERAPY Vol. 36; no. Supplement1; pp. 424 - 427 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1988
公益社団法人 日本化学療法学会 |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.36.Supplement1_424 |
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| Abstract | A new oral cephem antibiotic, CS-807 was administered to 12 patients with respiratory infections, 10 of outpatients and 2 of inpatients. The drug was given a daily dose of 400mg, b. i. d. in 8 patients, 200mg, b. i. d. in 3 patients, and 300mg, t. i. d. in one patient for 5 to 14 days. The clinical result was good in 8 cases and fair in 4 cases. In all cases, normalize of fever, WBC, CRP and ESR, and amelioration of sputum property and decrease of sputum volume were observed in several days after medication. Moreover, in 4 cases with pneumonia marked recovery of chest X-ray findings was found. Bacteriologically, isolates of S. aureus were eradicated in 3 cases and not evaluable in one case, and isolate of H. influenzae was decrease in one case. No side-effect was observed in all cases. Abnormal laboratory values were increase of eosinophile number and slightly elevated GOT, GPT in one case each. None were serious. |
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| AbstractList | A new oral cephem antibiotic, CS-807 was administered to 12 patients with respiratory infections, 10 of outpatients and 2 of inpatients. The drug was given a daily dose of 400mg, b. i. d. in 8 patients, 200mg, b. i. d. in 3 patients, and 300mg, t. i. d. in one patient for 5 to 14 days. The clinical result was good in 8 cases and fair in 4 cases. In all cases, normalize of fever, WBC, CRP and ESR, and amelioration of sputum property and decrease of sputum volume were observed in several days after medication. Moreover, in 4 cases with pneumonia marked recovery of chest X-ray findings was found. Bacteriologically, isolates of S. aureus were eradicated in 3 cases and not evaluable in one case, and isolate of H. influenzae was decrease in one case. No side-effect was observed in all cases. Abnormal laboratory values were increase of eosinophile number and slightly elevated GOT, GPT in one case each. None were serious. A new oral cephem antibiotic, CS-807 was administered to 12 patients with respiratory infections, 10 of outpatients and 2 of inpatients. The drug was given a daily dose of 400mg, b. i. d. in 8 patients, 200mg, b. i. d. in 3 patients, and 300mg, t. i. d. in one patient for 5 to 14 days. The clinical result was good in 8 cases and fair in 4 cases. In all cases, normalize of fever, WBC, CRP and ESR, and amelioration of sputum property and decrease of sputum volume were observed in several days after medication. Moreover, in 4 cases with pneumonia marked recovery of chest X-ray findings was found. Bacteriologically, isolates of S. aureus were eradicated in 3 cases and not evaluable in one case, and isolate of H. influenzae was decrease in one case. No side-effect was observed in all cases. Abnormal laboratory values were increase of eosinophile number and slightly elevated GOT, GPT in one case each. None were serious. 新経口セフェム剤CS-807の臨床有用性について検討した。対象は内科外来患者10例, 入院患者2例の計12例で, すべて呼吸器感染症であった。投与量は400mg 1日分2が8例, 200mg1日分2が3例, 300mg 1日分3が1例で, 投与日数は5～14日である。全12例の投与成績は, 有効8例, やや有効4例であり, 良好な治療成績を得た。全例で投与数日内に解熱白血球数, CRP, 血沈の正常化, 喀痰の性状の改善, 喀痰量の減少が見られ, さらに肺炎の4例では胸部X線所見の著明な改善がみられた。分離菌別ではS. aureus4例では1例が投与後の菌検査のデータがなく不明であったが残り3例はすべて消失, H. influenzae 1例では減少であった。副作用は自他覚症状は全例に認めないが臨床検査値異常として好酸球増多と軽度のGOT・GPT上昇が1例ずつ出現したのみで, 重篤なものは認められなかった。 |
| Author | HARADA, TOSHIKAZU KATO, TATSUO MASHIMO, KEIMEI YAMANE, YOSHIJI |
| Author_FL | 加藤 達雄 真下 啓明 原田 俊一 山根 至二 |
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| References | 1) 第35回日本化学療法学会総会新薬シンポジウムII, CS-807, 1987, 盛岡 |
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| Title | CLINICAL STUDY ON CS-807 IN RESPIRATORY INFECTIONS |
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