MICROBIOLOGICAL EVALUATION OF PANIPENEM/BETAMIPRON, A NEW PARENTERALLY ACTIVE CARBAPENEM III. IN VIVO ANTIBACTERIAL ACTIVITIES

• Published in: CHEMOTHERAPY Vol. 39; no. Supplement3; pp. 111 - 123
• Main Authors: Fukuoka, Takashi, Kasahara, Mayumi, Narita, Teruo, Yasuda, Hiroshi, Kuwahara, Shogo, Koga, Tetsufumi, Ajiki, Yoko, Iijima, Masako, Katsuta, Mitsuo, Takenouchi, Takashi
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1991; 公益社団法人 日本化学療法学会
• Subjects: In vivo抗菌力; Panipenem; Panipenem/betamipron; マウス腹腔内感染; 局所感染系
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.39.Supplement3_111

The in vivo antibacterial activities of panipenem/betamipron (PAPM/BP) and panipenem (PAPM) were evaluated against various experimental infections in mice or rats and compared with those of imipenem (IPM), imipenem/cilastatin (IPM/CS), cefazolin, cefotaxime, latamoxef, etc. Serum and organ levels of PAPM in mice and rats were also investigated. The fact that PAPM/BP showed almost the same antibacterial activities as PAPM in mice intraperitoneal infections indicates that BP has no influence on the antibacterial activity of PAPM. In mice, PAPM showed good therapeutic efficacy against intraperitoneal infections induced by 35 strains of 16 species of Gram-positive and Gram-negative bacteria including Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa. Especially, the in vivo anti-P. aeruginosa activities of PAPM were found to be almost equal to or better than those of IPM in mice systemic infections coused by 10 strains of P. aeruginosa. In leukopenic mice, PAPM showed good therapeutic effects on intraperitoneal infections. In rats, the efficacies of PAPM against intrapouch infections caused by S. aureus, Escherichia coli or P. aeruginosa were almost equal to those of imipenem. Against a tissue cage infection model in rats caused by S. aureus, PAPM/BP showed better efficacy than IPM/CS. In rat experimental infective endocarditis caused by P. aeruginosa, the efficacy of PAPM/BP was almost equal to that of IPM/CS.