Basic and clinical evaluation of FK037

• Published in: CHEMOTHERAPY Vol. 42; no. Supplement3; pp. 153 - 157
• Main Authors: Fukayama, Makiko, Sano, Yasuyuki, Tanaka, Yasuko, Masuda, Yoshishige, Shimada, Kaoru, Akiyama, Norihisa, Inamatsu, Takashi
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1994; 公益社団法人 日本化学療法学会
• Subjects: FK037; 内科領域感染症; 高齢者の体内動態
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.42.Supplement3_153

We evaluated a dosing plan in elderly patients and clinical efficacy of FK037, a new injectable cephem antibiotic. Bile, blood, urine and sputum samples were collected serially from 2 elderly patients after 1 g i.v. 60 min infusion of FK037. The peak concentrations of FK037 in plasma were 53.5-82.1μg/ml and T 1/2 β were 3.12-8.01 hrs. Urinary recovery rate up to 8 hrs were 49.0-58.7%. Sputum concentration pointed 0.67 μg/ml at 3 hrs after administration. Bile concentrations kept 12.3-16.1 μg/ml for 8 hrs. The clinical evaluation was carried out in 13 patients (pneumonia 6, chronic bronchitis 2, infected bronchiectasis 1, otitis media 1, cholecystitis, cholangitis 1, acute cholecystitis 1, cholangitis (suspicion) 1). The clinical efficacy was available in 10 cases which were excellent in 5 and good in 5. No adverse reactions or abnormal laboratory findings were observed on this trial.