MEROPENEM IN RESPIRATORY TRACT INFECTION
We studied the clinical efficacy, bacteriological effect and safety of a new carbapenem antibiotic, meropenem (MEPM). MEPM was administered to 11 patients with respiratory tract infection, including 8 cases of pneumonia, 1 of bronchiectasis with acute exacerbation, 1 of thoracic empyema and 1 of pul...
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| Published in | CHEMOTHERAPY Vol. 40; no. Supplement1; pp. 869 - 873 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1992
公益社団法人 日本化学療法学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.40.Supplement1_869 |
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| Abstract | We studied the clinical efficacy, bacteriological effect and safety of a new carbapenem antibiotic, meropenem (MEPM). MEPM was administered to 11 patients with respiratory tract infection, including 8 cases of pneumonia, 1 of bronchiectasis with acute exacerbation, 1 of thoracic empyema and 1 of pulmonary tuberculosis with secondary infection. The drugs were given intravenously for 13-5 days at a dose of 0.5 g, twice a day. Clinical efficacy was excellent in 2 cases, good in 5, fair in 2, poor in 1, and unknown in 1. No adverse reactions were observed in clinical findings, but laboratory findings revealed slight elevation of s-GPT in 3 cases, and of platelets, eosinophils and s-amylase in 1 case each. |
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| AbstractList | We studied the clinical efficacy, bacteriological effect and safety of a new carbapenem antibiotic, meropenem (MEPM). MEPM was administered to 11 patients with respiratory tract infection, including 8 cases of pneumonia, 1 of bronchiectasis with acute exacerbation, 1 of thoracic empyema and 1 of pulmonary tuberculosis with secondary infection. The drugs were given intravenously for 13-5 days at a dose of 0.5 g, twice a day. Clinical efficacy was excellent in 2 cases, good in 5, fair in 2, poor in 1, and unknown in 1. No adverse reactions were observed in clinical findings, but laboratory findings revealed slight elevation of s-GPT in 3 cases, and of platelets, eosinophils and s-amylase in 1 case each. We studied the clinical efficacy, bacteriological effect and safety of a new carbapenem antibiotic, meropenem (MEPM). MEPM was administered to 11 patients with respiratory tract infection, including 8 cases of pneumonia, 1 of bronchiectasis with acute exacerbation, 1 of thoracic empyema and 1 of pulmonary tuberculosis with secondary infection. The drugs were given intravenously for 13-5 days at a dose of 0.5 g, twice a day.Clinical efficacy was excellent in 2 cases, good in 5, fair in 2, poor in 1, and unknown in 1.No adverse reactions were observed in clinical findings, but laboratory findings revealed slight elevation of s-GPT in 3 cases, and of platelets, eosinophils and s-amylase in 1 case each. 呼吸器感染症, 11例にmeropenem (MEPM) を投与し, その臨床的効果, 細菌学的効果, 副作用について検討した。投与方法は, MEPM, 1回0.5g, 1日2回の点滴静注で行い, 投与期間は13～15日であった。対象症例は, 細菌性肺炎8例, 気管支拡張症の急性増悪1例, 膿胸1例, 肺結核症 (1III1) の二次感染1例であり, その臨床効果は著効2例, 有効5例, やや有効2例, 無効1例, 判定不能1例と有効率 (著効および有効) は70%であった。対象症例よりの原因菌はStreptococcus pneumoniae3例, Haemophitus influenzae 2例, Klebsiella pneumoniae2例, Pseudomonas anginosa1例など計10症例で検出され, 本剤投与により菌消失4例, 1例で菌減少, 3例で菌交代, 判定不能2例であった。副作用は全例で認められなかったが, 臨床検査値異常として, GPTの軽度上昇3例, 血小板数増多1例, 好酸球増多1例, 血清アミラーゼ上昇1例が認められた。以上より, 種々の呼吸器感染症に対しての本剤の有効性が示唆された。 |
| Author | Toyoshima, Hideo Ishii, Hisao Aritomi, Takamichi Ikeda, Akihito Nakanishi, Masayuki Takayama, Masanori Watanabe, Kentaro Yoshida, Minoru |
| Author_FL | 吉田 稔 豊島 秀夫 池田 昭仁 高山 昌紀 渡辺 憲太朗 有冨 貴道 中西 真之 石井 久雄 |
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| References | 1) Tanio T, Nouda H, Tada E, Kohzuki T, Kato M, Fukasawa M, Okuda T, Kamidono S: SM-7338 a new carbapenem antibiotic: Renal dehydropeptidase-I stability and pharmacokinetics in animals. 27th ICAAC, New York. Abstract no.758, 1987 2) Sumita Y, Inoue M, Mitsuhashi S: In vitro antibacterial activity and β-lactamase stability of the new carbapenem SM-7338. Eur J Clin Microbiol Infect Dis 8: 908-916, 1989 |
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| SubjectTerms | MEPM Meropenem 呼吸器感染症 |
| Title | MEROPENEM IN RESPIRATORY TRACT INFECTION |
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