MEROPENEM IN RESPIRATORY TRACT INFECTION

• Published in: CHEMOTHERAPY Vol. 40; no. Supplement1; pp. 869 - 873
• Main Authors: Takayama, Masanori, Ishii, Hisao, Yoshida, Minoru, Aritomi, Takamichi, Nakanishi, Masayuki, Ikeda, Akihito, Toyoshima, Hideo, Watanabe, Kentaro
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1992; 公益社団法人 日本化学療法学会
• Subjects: MEPM; Meropenem; 呼吸器感染症
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.40.Supplement1_869

We studied the clinical efficacy, bacteriological effect and safety of a new carbapenem antibiotic, meropenem (MEPM). MEPM was administered to 11 patients with respiratory tract infection, including 8 cases of pneumonia, 1 of bronchiectasis with acute exacerbation, 1 of thoracic empyema and 1 of pulmonary tuberculosis with secondary infection. The drugs were given intravenously for 13-5 days at a dose of 0.5 g, twice a day. Clinical efficacy was excellent in 2 cases, good in 5, fair in 2, poor in 1, and unknown in 1. No adverse reactions were observed in clinical findings, but laboratory findings revealed slight elevation of s-GPT in 3 cases, and of platelets, eosinophils and s-amylase in 1 case each.