FLEROXACIN IN UROGENITAL INFECTIONS

• Published in: CHEMOTHERAPY Vol. 38; no. Supplement2; pp. 539 - 545
• Main Authors: MATSUMOTO, TETSURO, HIRATA, HIROSHI, KOMATSU, KIYOSHI, KOIKAWA, YASUHIRO, TANAKA, MASATOSHI, KUMAZAWA, JOICHI, OGATA, NOBUO, HARA, SANSHIN, MIYAZAKI, NORIYOSHI
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1990; 公益社団法人 日本化学療法学会
• Subjects: Fleroxacin; 複雑性尿路感染症
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.38.Supplement2_539

Fleroxacin, a novel new-quinolone, was administered to 17 patients and the results described below were obtained. 1. Of 11 patients with complicated urinary tract infection (UTI), excellent results were observed in 2, moderate in 4 and poor in 5. The overall clinical efficacy rate was 54.5%. 2. In bacteriological response, 9 of 14 strains (64.3%) were diminished. 3. As classified by dose and timing, clinical efficacy rates were 40% in the 100mg once daily group, 66.7% in the 200mg once daily group and 66.7% in the 200mg twice daily group. 4. Clinical efficacy in one case of acute uncomplicated cystitis was excellent. 5. Side effects were stomach discomfort and diarrhea in one case, and abnormal elevation of GOT, GPT and ALP in another.