MICROBIOLOGICAL EVALUATION OF PANIPENEM/BETAMIPRON, A NEW PARENTERALLY ACTIVE CARBAPENEM I. IN VITRO ANTIBACTERIAL ACTIVITIES

• Published in: CHEMOTHERAPY Vol. 39; no. Supplement3; pp. 83 - 101
• Main Authors: Utsui, Yukio, Kasahara, Mayumi, Narita, Teruo, Yasuda, Hiroshi, Kuwahara, Shogo, Domon, Haruki, Tajima, Masazoh, Sekine, Naoko, Ajiki, Yohko, Ohya, Satoshi, Katsuta, Mitsuo, Takenouchi, Takashi
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1991; 公益社団法人 日本化学療法学会
• Subjects: In vitro抗菌活性; Panipenem; Panipenem/betamipron
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.39.Supplement3_83

In vitro antibacterial activities of a new carbapenem antibiotic panipenem (PAPM), an active component of parenterally effective panipenem/betamipron (PAPM/BP), were investigated, as compared to those of imipenem and other β-lactam antibiotics. 1) PAPM possessed broad antibacterial spectrum together with potent antibacterial activity against both Gram-positive and Gram-negative bacteria. 2) PAPM showed potent antibacterial activity, comparable to imipenem (IPM) against most of clinical isolates as well as greater than cefotaxime (CTX), latamoxef (LMOX), ceftazidime (CAZ), cefuzonam (CZON), flomoxef (FMOX), and piperacillin (PIPC) except for a few species of Gramnegative bacteria. 3) PAPM, furthermore, was more active than CTX, LMOX, CAZ, CZON, FMOX, and PIPC against methicillin-resistant Staphylococcus aureus and/or cephem-resistant Gram-negative rods as well. 4) PAPM was not affected by several media, medium pH, addition of horse serum into medium, and inoculum size in the expression of antibacterial activity. 5) PAPM exerted stronger bactericidal activity with the addition of drug, as compared to cefoperazone (CPZ), LMOX, CAZ, and PIPC. 6) PAPM induced acquisition of resistance in test bacteria to smaller extent than 1PM, CPZ, LMOX, CAZ, CZON, and PIPC did even by 15 times subculture repeatedly.