変形性膝関節症に対する予防リハビリテーションの新展開
変形性膝関節症は軟骨変性を主な病態とし，進行性の運動器疾患である．このため，発症および進行を予防するメカニズムの解明は，健康寿命延伸を目標と掲げる日本において喫緊の課題である．これまでの多くの研究で，運動が軟骨変性予防に効果的であると報告されている．本講座では，“変形性関節症が発症しにくい軟骨組織を創造するための軟骨細胞を強くすること” を目指し，分子，細胞から個体といった多階層にわたる生体システムの理解から予防リハビリテーションの基盤構築に向けた試みを紹介する．...
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| Published in | Japanese Journal of Allied Health and Rehabilitation Vol. 22; no. 1; pp. 41 - 46 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 多専会 専門リハビリテーション研究会
2023
Senmon Rehabilitation Kenkyukai |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1347-2550 2434-7124 |
| DOI | 10.34454/senmonreha.22.1_41 |
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| Abstract | 変形性膝関節症は軟骨変性を主な病態とし，進行性の運動器疾患である．このため，発症および進行を予防するメカニズムの解明は，健康寿命延伸を目標と掲げる日本において喫緊の課題である．これまでの多くの研究で，運動が軟骨変性予防に効果的であると報告されている．本講座では，“変形性関節症が発症しにくい軟骨組織を創造するための軟骨細胞を強くすること” を目指し，分子，細胞から個体といった多階層にわたる生体システムの理解から予防リハビリテーションの基盤構築に向けた試みを紹介する． |
|---|---|
| AbstractList | 変形性膝関節症は軟骨変性を主な病態とし，進行性の運動器疾患である．このため，発症および進行を予防するメカニズムの解明は，健康寿命延伸を目標と掲げる日本において喫緊の課題である．これまでの多くの研究で，運動が軟骨変性予防に効果的であると報告されている．本講座では，“変形性関節症が発症しにくい軟骨組織を創造するための軟骨細胞を強くすること” を目指し，分子，細胞から個体といった多階層にわたる生体システムの理解から予防リハビリテーションの基盤構築に向けた試みを紹介する． |
| Author | 金村, 尚彦 川端, 空 村田, 健児 |
| Author_FL | 川端 空 金村 尚彦 村田 健児 |
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| References | 3) Christiansen BA, Guilak F, Lockwood KA, et al.: Noninvasive mouse models of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015; 23: 1627-1638. 5) Brown SB, Hornyak JA, Jungels RR, et al.: Characterization of Post-Traumatic Osteoarthritis in Rats Following Anterior Cruciate Ligament Rupture by Non-Invasive Knee Injury (NIKI). J Orthop Res. 2020; 38: 356-367. 14) Iijima H, Gilmer G, Wang K, et al.: Meta-analysis integrated with multi-omics data analysis to elucidate pathogenic mechanisms of age-related knee osteoarthritis in mice. J Gerontol A Biol Sci Med Sci. 2022; 77: 1321-1334. 15) Kawabata S, Ozone K, Minegishi Y, et al.: Chronic ankle joint instability induces ankle sensorimotor dysfunction: a controlled laboratory study. Am J Sports Med. Published online January 27, 2024: 03635465231217490. 22) Iijima H, Aoyama T, Ito A, et al.: Effects of short-term gentle treadmill walking on subchondral bone in a rat model of instability-induced osteoarthritis. Osteoarthritis Cartilage. 2015; 23: 1563-1574. 19) Raposo F, Ramos M, Lúcia Cruz A: Effects of exercise on knee osteoarthritis: A systematic review. Musculoskeletal Care. 2021; 19: 399-435. 21) Oka Y, Murata K, Kano T, et al.: Impact of controlling abnormal joint movement on the effectiveness of subsequent exercise intervention in mouse models of early knee osteoarthritis. Cartilage. 2021; 13(2_suppl): 1334S-1344S. 7) Wink AE, Gross KD, Brown CA, et al.: Varus thrust during walking and the risk of incident and worsening medial tibiofemoral MRI lesions: the Multicenter Osteoarthritis Study. Osteoarthritis Cartilage. 2017; 25: 839-845. 1) Hayami T, Pickarski M, Wesolowski GA, et al.: The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum. 2004; 50: 1193-1206. 9) Murata K, Kokubun T, Takayanagi K: Restoring knee joint kinematics after anterior cruciate ligament injury might inhibit synovial membrane inflammation. Sport Sci Health. Published online 2019. https://link.springer.com/article/10.1007/s11332-018-0481-y. 13) Hayami T, Pickarski M, Zhuo Y, et al.: Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone. 2006; 38: 234-243. 8) Tochigi Y, Vaseenon T, Heiner AD, et al.: Instability dependency of osteoarthritis development in a rabbit model of graded anterior cruciate ligament transection. J Bone Joint Surg Am. 2011; 93: 640-647. 10) Murata K, Kanemura N, Kokubun T, et al.: Controlling joint instability delays the degeneration of articular cartilage in a rat model. Osteoarthritis Cartilage. 2017; 25: 297-308. 16) Li S, Wang H, Zhang Y, et al.: COL3A1 and MMP9 serve as potential diagnostic biomarkers of osteoarthritis and are associated with immune cell infiltration. Front Genet. 2021; 12: 721258. 2) Glasson SS, Blanchet TJ, Morris EA: The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage. 2007; 15: 1061-1069. 12) Murata K, Kokubun T, Onitsuka K, et al.: Controlling joint instability after anterior cruciate ligament transection inhibits transforming growth factor-beta-mediated osteophyte formation. Osteoarthritis Cartilage. 2019; 27: 1185-1196. 4) Ramme AJ, Lendhey M, Raya JG, et al.: A novel rat model for subchondral microdamage in acute knee injury: a potential mechanism in post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2016; 24: 1776-1785. 6) Chang AH, Moisio KC, Chmiel JS, et al.: External knee adduction and flexion moments during gait and medial tibiofemoral disease progression in knee osteoarthritis. Osteoarthritis Cartilage. 2015; 23: 1099-1106. 17) Gibbs AJ, Gray B, Wallis JA, et al.: Recommendations for the management of hip and knee osteoarthritis: A systematic review of clinical practice guidelines. Osteoarthritis Cartilage. 2023; 31: 1280-1292. 11) Onitsuka K, Murata K, Kokubun T, et al.: Effects of Controlling Abnormal Joint Movement on Expression of MMP13 and TIMP-1 in Osteoarthritis. Cartilage. 2020; 11: 98-107. 18) Kawabata S, Murata K, Nakao K, et al.: Effects of exercise therapy on joint instability in patients with osteoarthritis of the knee: a systematic review. Osteoarthritis and Cartilage Open. 2020; 2: 100114. 20) Murata K, Sakakida T, Kawabata S, et al.: The effect of orthosis management on joint instability in knee joint disease: A systematic review. Prosthet Orthot Int. Published online September 14, 2023. doi:10.1097/ PXR.0000000000000289. |
| References_xml | – reference: 1) Hayami T, Pickarski M, Wesolowski GA, et al.: The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum. 2004; 50: 1193-1206. – reference: 9) Murata K, Kokubun T, Takayanagi K: Restoring knee joint kinematics after anterior cruciate ligament injury might inhibit synovial membrane inflammation. Sport Sci Health. Published online 2019. https://link.springer.com/article/10.1007/s11332-018-0481-y. – reference: 19) Raposo F, Ramos M, Lúcia Cruz A: Effects of exercise on knee osteoarthritis: A systematic review. Musculoskeletal Care. 2021; 19: 399-435. – reference: 5) Brown SB, Hornyak JA, Jungels RR, et al.: Characterization of Post-Traumatic Osteoarthritis in Rats Following Anterior Cruciate Ligament Rupture by Non-Invasive Knee Injury (NIKI). J Orthop Res. 2020; 38: 356-367. – reference: 3) Christiansen BA, Guilak F, Lockwood KA, et al.: Noninvasive mouse models of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015; 23: 1627-1638. – reference: 21) Oka Y, Murata K, Kano T, et al.: Impact of controlling abnormal joint movement on the effectiveness of subsequent exercise intervention in mouse models of early knee osteoarthritis. Cartilage. 2021; 13(2_suppl): 1334S-1344S. – reference: 22) Iijima H, Aoyama T, Ito A, et al.: Effects of short-term gentle treadmill walking on subchondral bone in a rat model of instability-induced osteoarthritis. Osteoarthritis Cartilage. 2015; 23: 1563-1574. – reference: 8) Tochigi Y, Vaseenon T, Heiner AD, et al.: Instability dependency of osteoarthritis development in a rabbit model of graded anterior cruciate ligament transection. J Bone Joint Surg Am. 2011; 93: 640-647. – reference: 12) Murata K, Kokubun T, Onitsuka K, et al.: Controlling joint instability after anterior cruciate ligament transection inhibits transforming growth factor-beta-mediated osteophyte formation. Osteoarthritis Cartilage. 2019; 27: 1185-1196. – reference: 16) Li S, Wang H, Zhang Y, et al.: COL3A1 and MMP9 serve as potential diagnostic biomarkers of osteoarthritis and are associated with immune cell infiltration. Front Genet. 2021; 12: 721258. – reference: 10) Murata K, Kanemura N, Kokubun T, et al.: Controlling joint instability delays the degeneration of articular cartilage in a rat model. Osteoarthritis Cartilage. 2017; 25: 297-308. – reference: 15) Kawabata S, Ozone K, Minegishi Y, et al.: Chronic ankle joint instability induces ankle sensorimotor dysfunction: a controlled laboratory study. Am J Sports Med. Published online January 27, 2024: 03635465231217490. – reference: 20) Murata K, Sakakida T, Kawabata S, et al.: The effect of orthosis management on joint instability in knee joint disease: A systematic review. Prosthet Orthot Int. Published online September 14, 2023. doi:10.1097/ PXR.0000000000000289. – reference: 11) Onitsuka K, Murata K, Kokubun T, et al.: Effects of Controlling Abnormal Joint Movement on Expression of MMP13 and TIMP-1 in Osteoarthritis. Cartilage. 2020; 11: 98-107. – reference: 2) Glasson SS, Blanchet TJ, Morris EA: The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage. 2007; 15: 1061-1069. – reference: 13) Hayami T, Pickarski M, Zhuo Y, et al.: Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone. 2006; 38: 234-243. – reference: 14) Iijima H, Gilmer G, Wang K, et al.: Meta-analysis integrated with multi-omics data analysis to elucidate pathogenic mechanisms of age-related knee osteoarthritis in mice. J Gerontol A Biol Sci Med Sci. 2022; 77: 1321-1334. – reference: 4) Ramme AJ, Lendhey M, Raya JG, et al.: A novel rat model for subchondral microdamage in acute knee injury: a potential mechanism in post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2016; 24: 1776-1785. – reference: 17) Gibbs AJ, Gray B, Wallis JA, et al.: Recommendations for the management of hip and knee osteoarthritis: A systematic review of clinical practice guidelines. Osteoarthritis Cartilage. 2023; 31: 1280-1292. – reference: 6) Chang AH, Moisio KC, Chmiel JS, et al.: External knee adduction and flexion moments during gait and medial tibiofemoral disease progression in knee osteoarthritis. Osteoarthritis Cartilage. 2015; 23: 1099-1106. – reference: 7) Wink AE, Gross KD, Brown CA, et al.: Varus thrust during walking and the risk of incident and worsening medial tibiofemoral MRI lesions: the Multicenter Osteoarthritis Study. Osteoarthritis Cartilage. 2017; 25: 839-845. – reference: 18) Kawabata S, Murata K, Nakao K, et al.: Effects of exercise therapy on joint instability in patients with osteoarthritis of the knee: a systematic review. Osteoarthritis and Cartilage Open. 2020; 2: 100114. |
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| SubjectTerms | 変形性膝関節症 運動療法 関節不安定性 |
| Title | 変形性膝関節症に対する予防リハビリテーションの新展開 |
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