悪性リンパ腫患者に発症した上顎サイトメガロウイルス感染症の1例

• Published in: 日本口腔外科学会雑誌 Vol. 58; no. 11; pp. 618 - 622
• Main Authors: 河原, 康, 渡邉, 裕之, 石井, 興, 宮地, 斉, 佐野, 大輔, 神谷, 祐司
• Format: Journal Article
• Language: Japanese
• Published: 社団法人 日本口腔外科学会 20.11.2012
• Subjects: サイトメガロウイルス; 免疫不全; 悪性リンパ腫
• ISSN: 0021-5163; 2186-1579
• DOI: 10.5794/jjoms.58.618

We report a case of cytomegalovirus infection of the maxilla in a patient with malignant lymphoma. A 71-year-old woman who had received chemotherapy for malignant lymphoma for 12 years visited a local dentist because of pain in the right anterior maxilla, and apical periodontitis was diagnosed. Although she received root canal therapy and oral antimicrobial agents, her symptoms worsened, and she visited our hospital. She had a fever of 37.4℃ and swelling, redness, and spontaneous pain of the maxillary mucosa. Initial blood tests showed a leukocyte count of 2,100/mm3 and a C-reactive protein level of 34.8 mg/dL, indicating an acute inflammatory response. She was admitted and received antimicrobial agents, granulocyte colony-stimulating factor, and γ-globulin. However, necrosis of the gingiva and alveolar bone of the right anterior maxilla progressed day by day. Although a biopsy was performed on the suspected recurrence of malignant lymphoma, no malignant cells were identified. As the patient's condition improved, her symptoms subsided. However, since reinfection occurred later at the same site, curettage was performed. Histopathological examination of the curetted tissue established a diagnosis of cytomegalovirus infection. Subsequently, with the improvement of general condition, the oral symptoms also subsided.