上下顎歯肉に発生したメトトレキサート関連リンパ球増殖性疾患の1例
Patients with rheumatoid arthritis often receive methotrexate (MTX). Recently, it has been shown that MTX can cause B cell lymphoma, non-Hodgkin's lymphoma. B cell lymphoma caused by MTX is referred to as a methotrexate-associated lymphoproliferative disorder (MTX-LPD) and is recognized by the...
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| Published in | 日本口腔外科学会雑誌 Vol. 59; no. 3; pp. 197 - 201 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
社団法人 日本口腔外科学会
20.03.2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.59.197 |
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| Abstract | Patients with rheumatoid arthritis often receive methotrexate (MTX). Recently, it has been shown that MTX can cause B cell lymphoma, non-Hodgkin's lymphoma. B cell lymphoma caused by MTX is referred to as a methotrexate-associated lymphoproliferative disorder (MTX-LPD) and is recognized by the World Health Organization and included among immunodeficiency-associated LPD. We describe a rare case of MTX-LPD with osteonecrosis of the jaw of maxilla and mandible in which spontaneous complete remission was achieved. |
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| AbstractList | Patients with rheumatoid arthritis often receive methotrexate (MTX). Recently, it has been shown that MTX can cause B cell lymphoma, non-Hodgkin's lymphoma. B cell lymphoma caused by MTX is referred to as a methotrexate-associated lymphoproliferative disorder (MTX-LPD) and is recognized by the World Health Organization and included among immunodeficiency-associated LPD. We describe a rare case of MTX-LPD with osteonecrosis of the jaw of maxilla and mandible in which spontaneous complete remission was achieved. |
| Author | 古森, 孝英 木本, 明 古土井, 春吾 浅井, 知子 鈴木, 泰明 竹内, 純一郎 |
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| References | 17) Salloum E, Cooper DL, et al : Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. J Clin Oncol 14: 1943-1949, 1996. 12) 岸部 幹，吉野和美，他：顎下リンパ節腫大を主訴としたメトトレキセート関連リンパ増殖性疾患の1例．日耳鼻感染症 24: 52-58, 2006. 4) Yoneda T, Hagino H, et al : Bisphosphonate-related osteonecrosis of the jaw: position paper from the allied task force committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology and Japanese Society of Oral and Maxillofacial Surgeons. J Bone Miner Metab 28: 365-383, 2010. 6) 小池博文，西澤光弘，他：舌潰瘍を契機に診断されたMTX関連リンパ増殖性疾患の1例．日口外誌 56: 266-270, 2010. 27) Bongartz T, Sutton AJ, et al : Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 295: 2275-2285, 2006. 28) Deborah PMS and Alan JS : Anti-Tumor Necrosis Factor α Therapy and the Risk of Lymphoma in Rheumatoid Arthritis: No Clear Answer. Arthritis Rheum 50: 1703-1706, 2004. 21) Hummel M, Anagnostopoulos I, et al : Epstein-Barr virus in B-cell non-Hodgkin's lymphomas: unexpected infection patterns and different infection incidence in low- and high-grade types. J Pathol 175: 263-271, 1995. 9) 亀倉隆太，坪田 大，他：咽頭痛を主訴に初診したメトトレキサート関連リンパ増殖性疾患1例．耳喉頭頸 82: 79-83, 2010. 7) 住田知樹，加藤友美，他：関節リウマチ患者の上顎に発生したメトトレキセート誘発悪性リンパ腫が疑われた1例．日口外誌 55: 463-466, 2009 20) Alspaugh MA, Jensen FC, et al : Lymphocytes transformed by Epstein-Barr virus. Induction of nuclear antigen reactive with antibody in rheumatoid arthritis. J Exp Med 147: 1018-27, 1978. 26) 星田義彦，青笹克之，他：悪性リンパ腫のすべて.リンパ腫の発病機序．メトトレキセート：血液・腫瘍科，49（Suppl 4） : 136-140, 2004. 5) 山下陽介，岩井俊憲，他：ビスフォスフォネートによる上顎骨壊死とメトトレキサート関連リンパ増殖性疾患の併発を疑った1例．日口外誌 58: 371-375, 2012. 24) Kamel OW, Van RM, et al : Reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. N Engl J Med 328: 1317-1321, 1993. 2) Ellman MH, Hurwitz H, et al : Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate. J Rheumatol 18: 1741-1743, 1991. 8) 高野真吾，木下 淳，他：咽頭痛を初発症状としたメトトレキサート（MTX）関連リンパ増殖性疾患例．耳鼻臨床 103: 669-679, 2010. 1) 一般社団法人日本リウマチ学会MTX診療ガイドライン策定小委員会：関節リウマチ治療におけるメトトレキサート（MTX）診療ガイドライン2011年版，羊土社，東京，2012，42-57頁 10) 鈴木健介，永田基樹，他：MTX関連リンパ増殖性疾患と考えられた上顎歯肉悪性リンパ腫の1例．頭頸部外科 20: 211-216, 2010. 11) 藤田弥千，村木祐孝，他：血液内科と協力して治療を行った顎口腔領域悪性リンパ腫の3症例．日口診誌 20: 367-372, 2007. 23) Lymphoma Study Group of Japanease Pathologists: The World Health Organization classification of malignant lymphomas in Japan: Incidence of recently recognized entities. Pathol Int 50: 696-702, 2000. 22) Park S, Lee J, et al : The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma. Blood 110: 972-978, 2007. 13) Gaulard P, Swerdlow SH, et al : WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. World Health Organization Classification of tumors, IARC Press, Lyon, 2008, p350-351. 18) Kauppi M, Pukkala E, et al : Elevated incidence of hematologic malignancies in patients with Sjögren's syndrome compared with patients with rheumatoid arthritis（ Finland）. Cancer Causes Control 8: 201-204, 1997. 16) Kamel OW, Weiss LM, et al : Hodgkin's disease and lymphoproliferations resembling Hodgkin's disease in patients receiving long-term low-dose methotrexate therapy. Am J Surg Patho 20: 1279-1287, 1996. 3) Harris NL and Swerdlow SH : Methotrexate-associated lymphoproliferative disorders. Pathology andgenetics of tumors of hematopoietic and lymphoid tissues. World Health Organization Classification of Tumors, IARC Press, Lyon, 2001, p270-271. 15) Hoshida Y, Xu JX, et al : Lymphoproliferative disorders in rheumatoid arthritis: clinicopathologic analysis of 76 cases in relation to methotrexate medication. J Rheumatol 34: 322-331, 2007. 25) 北村 登，武井正美：関節リウマチにおけるリンパ腫発生の要因．医学の歩み．医歯薬出版，東京，2007，221: 415-419頁. 19) Baecklund M, Iliadou A, et al : Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum 54: 692-701, 2006. 14) Kojima M, Itoh H, et al : Methotrexate-associated lymphoproliferative disorders. A clinicopathological study of 13 Japanese cases. Pathol Res Pract 202: 679-685, 2006. |
| References_xml | – reference: 27) Bongartz T, Sutton AJ, et al : Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 295: 2275-2285, 2006. – reference: 18) Kauppi M, Pukkala E, et al : Elevated incidence of hematologic malignancies in patients with Sjögren's syndrome compared with patients with rheumatoid arthritis（ Finland）. Cancer Causes Control 8: 201-204, 1997. – reference: 21) Hummel M, Anagnostopoulos I, et al : Epstein-Barr virus in B-cell non-Hodgkin's lymphomas: unexpected infection patterns and different infection incidence in low- and high-grade types. J Pathol 175: 263-271, 1995. – reference: 23) Lymphoma Study Group of Japanease Pathologists: The World Health Organization classification of malignant lymphomas in Japan: Incidence of recently recognized entities. Pathol Int 50: 696-702, 2000. – reference: 13) Gaulard P, Swerdlow SH, et al : WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. World Health Organization Classification of tumors, IARC Press, Lyon, 2008, p350-351. – reference: 8) 高野真吾，木下 淳，他：咽頭痛を初発症状としたメトトレキサート（MTX）関連リンパ増殖性疾患例．耳鼻臨床 103: 669-679, 2010. – reference: 10) 鈴木健介，永田基樹，他：MTX関連リンパ増殖性疾患と考えられた上顎歯肉悪性リンパ腫の1例．頭頸部外科 20: 211-216, 2010. – reference: 26) 星田義彦，青笹克之，他：悪性リンパ腫のすべて.リンパ腫の発病機序．メトトレキセート：血液・腫瘍科，49（Suppl 4） : 136-140, 2004. – reference: 22) Park S, Lee J, et al : The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma. Blood 110: 972-978, 2007. – reference: 19) Baecklund M, Iliadou A, et al : Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum 54: 692-701, 2006. – reference: 9) 亀倉隆太，坪田 大，他：咽頭痛を主訴に初診したメトトレキサート関連リンパ増殖性疾患1例．耳喉頭頸 82: 79-83, 2010. – reference: 1) 一般社団法人日本リウマチ学会MTX診療ガイドライン策定小委員会：関節リウマチ治療におけるメトトレキサート（MTX）診療ガイドライン2011年版，羊土社，東京，2012，42-57頁． – reference: 20) Alspaugh MA, Jensen FC, et al : Lymphocytes transformed by Epstein-Barr virus. Induction of nuclear antigen reactive with antibody in rheumatoid arthritis. J Exp Med 147: 1018-27, 1978. – reference: 2) Ellman MH, Hurwitz H, et al : Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate. J Rheumatol 18: 1741-1743, 1991. – reference: 17) Salloum E, Cooper DL, et al : Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. J Clin Oncol 14: 1943-1949, 1996. – reference: 6) 小池博文，西澤光弘，他：舌潰瘍を契機に診断されたMTX関連リンパ増殖性疾患の1例．日口外誌 56: 266-270, 2010. – reference: 5) 山下陽介，岩井俊憲，他：ビスフォスフォネートによる上顎骨壊死とメトトレキサート関連リンパ増殖性疾患の併発を疑った1例．日口外誌 58: 371-375, 2012. – reference: 11) 藤田弥千，村木祐孝，他：血液内科と協力して治療を行った顎口腔領域悪性リンパ腫の3症例．日口診誌 20: 367-372, 2007. – reference: 25) 北村 登，武井正美：関節リウマチにおけるリンパ腫発生の要因．医学の歩み．医歯薬出版，東京，2007，221: 415-419頁. – reference: 28) Deborah PMS and Alan JS : Anti-Tumor Necrosis Factor α Therapy and the Risk of Lymphoma in Rheumatoid Arthritis: No Clear Answer. Arthritis Rheum 50: 1703-1706, 2004. – reference: 24) Kamel OW, Van RM, et al : Reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. N Engl J Med 328: 1317-1321, 1993. – reference: 14) Kojima M, Itoh H, et al : Methotrexate-associated lymphoproliferative disorders. A clinicopathological study of 13 Japanese cases. Pathol Res Pract 202: 679-685, 2006. – reference: 4) Yoneda T, Hagino H, et al : Bisphosphonate-related osteonecrosis of the jaw: position paper from the allied task force committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology and Japanese Society of Oral and Maxillofacial Surgeons. J Bone Miner Metab 28: 365-383, 2010. – reference: 3) Harris NL and Swerdlow SH : Methotrexate-associated lymphoproliferative disorders. Pathology andgenetics of tumors of hematopoietic and lymphoid tissues. World Health Organization Classification of Tumors, IARC Press, Lyon, 2001, p270-271. – reference: 7) 住田知樹，加藤友美，他：関節リウマチ患者の上顎に発生したメトトレキセート誘発悪性リンパ腫が疑われた1例．日口外誌 55: 463-466, 2009 – reference: 16) Kamel OW, Weiss LM, et al : Hodgkin's disease and lymphoproliferations resembling Hodgkin's disease in patients receiving long-term low-dose methotrexate therapy. Am J Surg Patho 20: 1279-1287, 1996. – reference: 15) Hoshida Y, Xu JX, et al : Lymphoproliferative disorders in rheumatoid arthritis: clinicopathologic analysis of 76 cases in relation to methotrexate medication. J Rheumatol 34: 322-331, 2007. – reference: 12) 岸部 幹，吉野和美，他：顎下リンパ節腫大を主訴としたメトトレキセート関連リンパ増殖性疾患の1例．日耳鼻感染症 24: 52-58, 2006. |
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| SubjectTerms | B細胞性リンパ腫 MTX関連リンパ増殖性疾患 関節リウマチ 非ホジキンリンパ腫 骨壊死 |
| Title | 上下顎歯肉に発生したメトトレキサート関連リンパ球増殖性疾患の1例 |
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