上下顎歯肉に発生したメトトレキサート関連リンパ球増殖性疾患の1例

• Published in: 日本口腔外科学会雑誌 Vol. 59; no. 3; pp. 197 - 201
• Main Authors: 鈴木, 泰明, 浅井, 知子, 古森, 孝英, 竹内, 純一郎, 木本, 明, 古土井, 春吾
• Format: Journal Article
• Language: Japanese
• Published: 社団法人 日本口腔外科学会 20.03.2013
• Subjects: B細胞性リンパ腫; MTX関連リンパ増殖性疾患; 関節リウマチ; 非ホジキンリンパ腫; 骨壊死
• ISSN: 0021-5163; 2186-1579
• DOI: 10.5794/jjoms.59.197

Patients with rheumatoid arthritis often receive methotrexate (MTX). Recently, it has been shown that MTX can cause B cell lymphoma, non-Hodgkin's lymphoma. B cell lymphoma caused by MTX is referred to as a methotrexate-associated lymphoproliferative disorder (MTX-LPD) and is recognized by the World Health Organization and included among immunodeficiency-associated LPD. We describe a rare case of MTX-LPD with osteonecrosis of the jaw of maxilla and mandible in which spontaneous complete remission was achieved.