1細胞解析からマクロファージの特性を紐解く

• Published in: 日本薬理学会年会要旨集 p. 2-B-S32-4
• Main Author: 増田, 隆博
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2023
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.97.0_2-B-S32-4

In order to deeply understand the principle of organisms, it is necessary to unravel the information of each cell existing in the organism. For many years, many cell types, such as nerves and macrophages, that make up living organisms have been thought to be homogeneous cell populations. However, it has become clear that in many cases, heterogeneity exists within each cell population, and that it is composed of cells with different states and functions. Recent advances in research technology have dramatically improved the sensitivity and accuracy of cell information analysis, enabling high-throughput analysis at the single-cell level, which makes it possible to conduct research targeting rare cells that may originally perform crucial functions, and to discover important changes that could not be known by analysis based on the classical assumption of a homogeneous cell population. In this symposium, I will discuss current knowledge about the characteristics of CNS macrophages that have recently been uncovered by single-cell analysis.