化学療法中に多発性膿瘍を伴った播種性Fusarium感染症を発症した急性混合型白血病の1例

A 17-year-old girl with mixed-phenotype acute leukemia was admitted to our hospital to receive induction chemotherapy. Because she had pain, swelling, and fever in the left cheek after starting chemotherapy, our department was consulted. There was no evidence of infection or tooth abscess formation...

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Published in日本口腔外科学会雑誌 Vol. 63; no. 4; pp. 232 - 236
Main Authors 青柳, 直子, 喜久田, 利弘, 喜多, 涼介, 高橋, 宏昌, 近藤, 誠二
Format Journal Article
LanguageJapanese
Published 社団法人 日本口腔外科学会 20.04.2017
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.63.232

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Summary:A 17-year-old girl with mixed-phenotype acute leukemia was admitted to our hospital to receive induction chemotherapy. Because she had pain, swelling, and fever in the left cheek after starting chemotherapy, our department was consulted. There was no evidence of infection or tooth abscess formation in the oral region at the first visit to our department; however, Fusarium species were detected on blood culture and sinus bacteria tests, and follow-up computed tomographic scanning showed the formation of an abscess in the left masseter muscle. A left buccal phlegmon was diagnosed and drained with the patient under the general anesthesia. Fusarium was detected on bacterial testing of the affected area. The multiple abscesses were caused by disseminated Fusarium infection in the muscles and subcutaneous tissues of the entire body as well as in the spleen. Drainage and treatment with antimicrobial agents were therefore performed. In recent years, mortality from disseminated Fusarium infections has increased in association with the intensification of chemotherapy. We conclude that meticulous attention is required to prevent disseminated Fusarium infection in immunosuppressed individuals.
ISSN:0021-5163
2186-1579
DOI:10.5794/jjoms.63.232