口腔領域の血管内乳頭状内皮過形成10例の臨床病理学的検討

• Published in: 日本口腔外科学会雑誌 Vol. 57; no. 1; pp. 2 - 7
• Main Authors: 朔, 敬, 飯田, 明彦, 林, 孝文, 小林, 孝憲, 齊藤, 力, 堀井, 信哉, 高木, 律男
• Format: Journal Article
• Language: Japanese
• Published: 社団法人 日本口腔外科学会 01.01.2011
• Subjects: 臨床病理学的検討; 血管内乳頭状内皮過形成; 血管内皮細胞; 血管腫; 超音波検査
• ISSN: 0021-5163; 2186-1579
• DOI: 10.5794/jjoms.57.2

Intravascular papillary endothelial hyperplasia （IPEH） is a reactive lesion histopathologically characterized by papillary proliferation of endothelial cells in organizing thrombi formed in dilated blood vascular spaces.We studied the clinicopathological features of 10 cases of IPEH treated at the Niigata University Hospital during the last 12 years from 1998 through 2009 and reviewed the literature. The patients were 5 men and 5 women.Their age mean was 51.2 years （range, 21 to 72）. The lesions were most frequently located in the lower lip （5 cases）, followed by the tongue （2 cases）, and the buccal mucosa, gingivobuccal fold, and maxillary sinus （1 each）. The lesions were all covered by mulberry-colored mucosae, measuring 8.6 mm in average diameter （range, 3 to 12 mm）, while they were rather elastic on palpation and did not always fade on compression. Most ofthe clinical diagnoses were hemangioma （7 cases）, while the diagnosis of hemangioma was ruled out in 2 cases arising in the lower lip and tongue by ultrasonography, which revealed high blood flow inside the lesion. All cases were surgically removed in accordance with the procedure for hemangioma, without recurrence. Thus, the application of ultrasonographic examination before surgery was suggested to be useful for the differential diagnosis of IPEH from hemangioma.