結核症の補助診断法としての糖脂質抗体価測定

結核症の補助診断に資する目的のため, Mycobacterium bovis BCG株より糖脂質AおよびC族を抽出精製し, 両者を抗原としたELISA法でヒトの血清IgG抗体価を測定した. 健常者30例ではA抗体, C抗体陽性例は各1例 (3.3%) であったのに対し, 活動性肺結核患者で排菌中または発症より3ヵ月以内の40例では, A抗体陽性14例 (35.0%), C抗体陽性28例 (70.0%) であり, いずれかが陽性を示したものは32例 (80.0%) と有意に高かった. 両抗体価は結核発症よりの時間経過とともに低下したが, C抗体価は発症より2年以上経過した結核患者でも22例中4例...

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Published in感染症学雑誌 Vol. 59; no. 10; pp. 984 - 995
Main Author 重岡, 秀信
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本感染症学会 1985
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ISSN0387-5911
1884-569X
DOI10.11150/kansenshogakuzasshi1970.59.984

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Abstract 結核症の補助診断に資する目的のため, Mycobacterium bovis BCG株より糖脂質AおよびC族を抽出精製し, 両者を抗原としたELISA法でヒトの血清IgG抗体価を測定した. 健常者30例ではA抗体, C抗体陽性例は各1例 (3.3%) であったのに対し, 活動性肺結核患者で排菌中または発症より3ヵ月以内の40例では, A抗体陽性14例 (35.0%), C抗体陽性28例 (70.0%) であり, いずれかが陽性を示したものは32例 (80.0%) と有意に高かった. 両抗体価は結核発症よりの時間経過とともに低下したが, C抗体価は発症より2年以上経過した結核患者でも22例中4例 (18.2%) の陽性例を認めた. 対照とした細菌性呼吸器感染症患者22例, 肺癌患者8例においては両抗体価とも陽性例はなく, 両抗体価を併せて測定することは結核症の補助診断法として有用と考えられた. 尚, これらの抗体価はツベルクリン反応の程度とは全く相関しなかった. また, 維持血液透析患者に併発した活動性結核患者では, 9例中A抗体陽性2例, C抗体陽性2例にすぎず, またその抗体価も低値であった.
AbstractList 結核症の補助診断に資する目的のため, Mycobacterium bovis BCG株より糖脂質AおよびC族を抽出精製し, 両者を抗原としたELISA法でヒトの血清IgG抗体価を測定した. 健常者30例ではA抗体, C抗体陽性例は各1例 (3.3%) であったのに対し, 活動性肺結核患者で排菌中または発症より3ヵ月以内の40例では, A抗体陽性14例 (35.0%), C抗体陽性28例 (70.0%) であり, いずれかが陽性を示したものは32例 (80.0%) と有意に高かった. 両抗体価は結核発症よりの時間経過とともに低下したが, C抗体価は発症より2年以上経過した結核患者でも22例中4例 (18.2%) の陽性例を認めた. 対照とした細菌性呼吸器感染症患者22例, 肺癌患者8例においては両抗体価とも陽性例はなく, 両抗体価を併せて測定することは結核症の補助診断法として有用と考えられた. 尚, これらの抗体価はツベルクリン反応の程度とは全く相関しなかった. また, 維持血液透析患者に併発した活動性結核患者では, 9例中A抗体陽性2例, C抗体陽性2例にすぎず, またその抗体価も低値であった.
Author 重岡, 秀信
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References 3) 稲本元: 透析患者における肺外核症の疫学的検討. 結核, Vol.56, No.9: 441-444, 1981.
11) Nassau, E., Parson, E. R. & Johnson, G. D.: The Detection of antibodies to Mycobacterium tuberculosis by micro-plate enzyme-linked immunosorbent assay (ELISA). Tubercle, 57: 67-70, 1976.
7) Pangborn, M. & Mckinney, J. A.: Purification of serologically active phosphoinositides of M. tuberculosis. J. Lipid Res., 7: 627-633, 1966.
9) Nassau, E. & Parsons, ER.: Deetection of antibodies to Mycobacterium Tuberculosis by solid phase radioimmunoassay. J. Immuno. Methods, 6: 261-271, 1975.
20) Mordersa, H. & Mordarski, M.: Chemotaxonomic characters and classification of some Nocardiofrom bacteria. J. General Microbiol., 71: 77-86, 1972.
17) Kaplan, M. H. & Chase, M. W.: ANtibodies to mycobacteria in human tuberculosis. I. Development of antibodies before and after antimicrobial therapy. J. Infec. Dis., 142: 825-834, 1980.
14) Schonheyder, H. & Anderson, P.: Effect of bovine serum albumin on antibody determination by the Enzyme-Linked Immunosorbent assay. J. Immunol. Methods, 72: 251-259, 1984.
6) Boquet, A. & Negre, L.: Sur les proprietes biologiques des lipoides du bacille tubercuieux. Ann. Inst. Pasteur Lille, 37: 787-791, 1923.
8) Reggiardo, Z. & Middlebrock, G.: Serologically active glycolipid families from Mycobacterium Bovin BCG, I. Extraction, Puurification and Immunologic studies. Am. J. Epidemiol., 100: 469-476, 1974.
10) Zeiss, C. R., Radin, R. C., Williams, J. E., Levitz, D. & Phair, J. P.: Detection of Immunoglobulin G antibody to purified protein derivative in patients with tuberculosis by radioimmunoassay and enzyme-linked immunosorbent assay. J. Clinical Microbiol., 15: 93-96, 1982.
2) 稲本元: 慢性腎不全患者の結核症に対する易感染性及び抵抗性に関する疫学的検討. 日内会誌, 70 (6): 14-20, 1981.
4) Middlebrock, G. & Dubos, RJ.: Specific serum agglutination of erythrocytes sensitized with extracts of tubercle bacilli. J. Exp. Med., 88: 521-528, 1948.
13) Engvall, E. & Perlmann, P.: Enzyme-linked immunosorbent assay III Quantitation of specific antibodies by enzyme labelled antiimmunoglobulin in antigen-coated bubes. J. Immunol., 109: 129-135, 1972.
15) Malvano, R., Bonilo, A., Dovis, M. & Zannino, M.: ELISA for antibody measurement Aspects related to data expression. J. Immunol. Methods, 48: 51-60, 1982.
18) Katz, P., Goldstein, R. A. & Fanci, A. S.: Immunoregulation in infection caused by mycobacterium tuberculosis The presence of suppressor monocytes and the alternation of subpopulation of T lymphocytes. J. Infec. Dis., 140: 12-21, 1979.
16) Kalish, S. B., Radin, R. C., Phair, J. P., Levitz, D., Zeiss, C. R. & Metzger, E.: Use of an enzymelinked immunosorbent assay technique in tne differential diagnosis of active tuberculosis in humans. J. Infec. Dis., 147: 523-530, 1983.
19) Carr, R. I., Charkraborty, A. K., Brunda, M. J., Davison, P. T., Dample, P. B., Hardtke, M. A., Girbride, K. J. & Minden, P.: Immune complexes and antibodies to BCG in sera from patients with mycobacterial infections. Clin. Exp. Immunol., 39: 562-569, 1980.
21) Kardjito, T. & Hardoyo, I.: Diagnosis of active tuberculosis by immunological methods. 1. The effect of Tuberculin reactivity and previous BCG vaccination on the antibody levels determined by ELISA. Tubercle, 63: 269-274, 1982.
22) Radin, R, C., Zeiss, C. R. & Phair, J. P.: Antibodies to purified protein derivative in different immunoglobulin classes in the diagnosis of tuberculosis inman. Int. Archs Allergy Appi. Immunol., 70: 25-29, 1983.
12) Reggiardo, Z., Vozquez, E. & Schnaper, L.: ELISA test for antibodies against mycobacterial glycolipids. J. Immunol. Methods, 34: 55-60, 1980.
1) 稲本元, 猪芳亮, 稲本伸子: 腎不全における免疫不全. 臨床免疫, 9 (4): 269-274, 1977.
5) Takahashi, Y.: Specific serum agglutination of kaolin particles sensitized with tubercle phosphatides and its clinical evaluation as a serodiagnostic test for tuberculosis. Am. Rev. Respir. Dis., 85: 708-719, 1962.
References_xml – reference: 12) Reggiardo, Z., Vozquez, E. & Schnaper, L.: ELISA test for antibodies against mycobacterial glycolipids. J. Immunol. Methods, 34: 55-60, 1980.
– reference: 18) Katz, P., Goldstein, R. A. & Fanci, A. S.: Immunoregulation in infection caused by mycobacterium tuberculosis The presence of suppressor monocytes and the alternation of subpopulation of T lymphocytes. J. Infec. Dis., 140: 12-21, 1979.
– reference: 21) Kardjito, T. & Hardoyo, I.: Diagnosis of active tuberculosis by immunological methods. 1. The effect of Tuberculin reactivity and previous BCG vaccination on the antibody levels determined by ELISA. Tubercle, 63: 269-274, 1982.
– reference: 5) Takahashi, Y.: Specific serum agglutination of kaolin particles sensitized with tubercle phosphatides and its clinical evaluation as a serodiagnostic test for tuberculosis. Am. Rev. Respir. Dis., 85: 708-719, 1962.
– reference: 9) Nassau, E. & Parsons, ER.: Deetection of antibodies to Mycobacterium Tuberculosis by solid phase radioimmunoassay. J. Immuno. Methods, 6: 261-271, 1975.
– reference: 17) Kaplan, M. H. & Chase, M. W.: ANtibodies to mycobacteria in human tuberculosis. I. Development of antibodies before and after antimicrobial therapy. J. Infec. Dis., 142: 825-834, 1980.
– reference: 22) Radin, R, C., Zeiss, C. R. & Phair, J. P.: Antibodies to purified protein derivative in different immunoglobulin classes in the diagnosis of tuberculosis inman. Int. Archs Allergy Appi. Immunol., 70: 25-29, 1983.
– reference: 3) 稲本元: 透析患者における肺外核症の疫学的検討. 結核, Vol.56, No.9: 441-444, 1981.
– reference: 19) Carr, R. I., Charkraborty, A. K., Brunda, M. J., Davison, P. T., Dample, P. B., Hardtke, M. A., Girbride, K. J. & Minden, P.: Immune complexes and antibodies to BCG in sera from patients with mycobacterial infections. Clin. Exp. Immunol., 39: 562-569, 1980.
– reference: 2) 稲本元: 慢性腎不全患者の結核症に対する易感染性及び抵抗性に関する疫学的検討. 日内会誌, 70 (6): 14-20, 1981.
– reference: 11) Nassau, E., Parson, E. R. & Johnson, G. D.: The Detection of antibodies to Mycobacterium tuberculosis by micro-plate enzyme-linked immunosorbent assay (ELISA). Tubercle, 57: 67-70, 1976.
– reference: 13) Engvall, E. & Perlmann, P.: Enzyme-linked immunosorbent assay III Quantitation of specific antibodies by enzyme labelled antiimmunoglobulin in antigen-coated bubes. J. Immunol., 109: 129-135, 1972.
– reference: 7) Pangborn, M. & Mckinney, J. A.: Purification of serologically active phosphoinositides of M. tuberculosis. J. Lipid Res., 7: 627-633, 1966.
– reference: 20) Mordersa, H. & Mordarski, M.: Chemotaxonomic characters and classification of some Nocardiofrom bacteria. J. General Microbiol., 71: 77-86, 1972.
– reference: 6) Boquet, A. & Negre, L.: Sur les proprietes biologiques des lipoides du bacille tubercuieux. Ann. Inst. Pasteur Lille, 37: 787-791, 1923.
– reference: 16) Kalish, S. B., Radin, R. C., Phair, J. P., Levitz, D., Zeiss, C. R. & Metzger, E.: Use of an enzymelinked immunosorbent assay technique in tne differential diagnosis of active tuberculosis in humans. J. Infec. Dis., 147: 523-530, 1983.
– reference: 1) 稲本元, 猪芳亮, 稲本伸子: 腎不全における免疫不全. 臨床免疫, 9 (4): 269-274, 1977.
– reference: 8) Reggiardo, Z. & Middlebrock, G.: Serologically active glycolipid families from Mycobacterium Bovin BCG, I. Extraction, Puurification and Immunologic studies. Am. J. Epidemiol., 100: 469-476, 1974.
– reference: 10) Zeiss, C. R., Radin, R. C., Williams, J. E., Levitz, D. & Phair, J. P.: Detection of Immunoglobulin G antibody to purified protein derivative in patients with tuberculosis by radioimmunoassay and enzyme-linked immunosorbent assay. J. Clinical Microbiol., 15: 93-96, 1982.
– reference: 4) Middlebrock, G. & Dubos, RJ.: Specific serum agglutination of erythrocytes sensitized with extracts of tubercle bacilli. J. Exp. Med., 88: 521-528, 1948.
– reference: 14) Schonheyder, H. & Anderson, P.: Effect of bovine serum albumin on antibody determination by the Enzyme-Linked Immunosorbent assay. J. Immunol. Methods, 72: 251-259, 1984.
– reference: 15) Malvano, R., Bonilo, A., Dovis, M. & Zannino, M.: ELISA for antibody measurement Aspects related to data expression. J. Immunol. Methods, 48: 51-60, 1982.
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Snippet 結核症の補助診断に資する目的のため, Mycobacterium bovis BCG株より糖脂質AおよびC族を抽出精製し, 両者を抗原としたELISA法でヒトの血清IgG抗体価を測定した. 健常者30...
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Title 結核症の補助診断法としての糖脂質抗体価測定
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