2．高尿酸血症
高尿酸血症は高血圧・CKDの発症・進展と密接に関連することがわかってきている．CKDにおいて，アロプリノールによる高尿酸血症治療は高血圧・腎障害の進展抑制をきたし，逆に高尿酸血症治療の中断はRA系抑制薬非服用群においてのみに，高血圧・腎機能の増悪をみるとされている．このことから，高尿酸血症がCKDにおける高血圧・腎障害の進展に関与する機序にはRA系の亢進が重要な役割を演じていることが示唆される．...
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| Published in | 日本内科学会雑誌 Vol. 100; no. 5; pp. 1206 - 1212 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本内科学会
2011
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5384 1883-2083 |
| DOI | 10.2169/naika.100.1206 |
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| Abstract | 高尿酸血症は高血圧・CKDの発症・進展と密接に関連することがわかってきている．CKDにおいて，アロプリノールによる高尿酸血症治療は高血圧・腎障害の進展抑制をきたし，逆に高尿酸血症治療の中断はRA系抑制薬非服用群においてのみに，高血圧・腎機能の増悪をみるとされている．このことから，高尿酸血症がCKDにおける高血圧・腎障害の進展に関与する機序にはRA系の亢進が重要な役割を演じていることが示唆される． |
|---|---|
| AbstractList | 高尿酸血症は高血圧・CKDの発症・進展と密接に関連することがわかってきている．CKDにおいて，アロプリノールによる高尿酸血症治療は高血圧・腎障害の進展抑制をきたし，逆に高尿酸血症治療の中断はRA系抑制薬非服用群においてのみに，高血圧・腎機能の増悪をみるとされている．このことから，高尿酸血症がCKDにおける高血圧・腎障害の進展に関与する機序にはRA系の亢進が重要な役割を演じていることが示唆される． |
| Author | 細谷, 龍男 大野, 岩男 |
| Author_xml | – sequence: 1 fullname: 細谷, 龍男 organization: 東京慈恵会医科大学腎臓・高血圧内科 – sequence: 1 fullname: 大野, 岩男 organization: 東京慈恵会医科大学腎臓・高血圧内科 |
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| Copyright | 2011 一般社団法人 日本内科学会 |
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| References | 9) Hikita M, et al: Relationship between hyperuricemia and body fat distribution. Internal Medicine 46: 1353-1358, 2007. 3) Franco MCP, et al: Effects of low birth weight in 8- to 13-year-old children implications in endothelial function and uric acid levels. Hypertension 48: 45-50, 2006. 6) Ohno I, et al: Serum uric acid and renal prognosis in patients with IgA nephropathy. Nephron 87: 333-339, 2001. 10) Johnson RJ, et al: Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41: 1183-1190, 2003. 8) Talaat KM, El-Sheikh AR: The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease. Am J Nephrol 27: 435-440, 2007. 1) Zhang W, et al: Plasma uric acid and hypertension in a Chinese community: prospective study and meta-analysis. Clin Chem 55: 2026-2034, 2009. 2) Feig DI, et al: Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA 300: 924-932, 2008. 4) Bellomo G, et al: Association of uric acid with change in kidney function in healthy normotensive individuals. Am J Kidney Dis 56: 264-272, 2010. 5) Obermayr RP, et al: Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol 19: 2407-2413, 2008. 7) Siu YP, et al: Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am J Kidney Dis 47: 51-59, 2005. |
| References_xml | – reference: 9) Hikita M, et al: Relationship between hyperuricemia and body fat distribution. Internal Medicine 46: 1353-1358, 2007. – reference: 7) Siu YP, et al: Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am J Kidney Dis 47: 51-59, 2005. – reference: 8) Talaat KM, El-Sheikh AR: The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease. Am J Nephrol 27: 435-440, 2007. – reference: 1) Zhang W, et al: Plasma uric acid and hypertension in a Chinese community: prospective study and meta-analysis. Clin Chem 55: 2026-2034, 2009. – reference: 3) Franco MCP, et al: Effects of low birth weight in 8- to 13-year-old children implications in endothelial function and uric acid levels. Hypertension 48: 45-50, 2006. – reference: 10) Johnson RJ, et al: Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41: 1183-1190, 2003. – reference: 2) Feig DI, et al: Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA 300: 924-932, 2008. – reference: 5) Obermayr RP, et al: Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol 19: 2407-2413, 2008. – reference: 6) Ohno I, et al: Serum uric acid and renal prognosis in patients with IgA nephropathy. Nephron 87: 333-339, 2001. – reference: 4) Bellomo G, et al: Association of uric acid with change in kidney function in healthy normotensive individuals. Am J Kidney Dis 56: 264-272, 2010. |
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| Title | 2．高尿酸血症 |
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