Skin Safety Evaluation of HKP-210
HKP-210 is a anodyne poultics containing 3 mg Ketoprofen in 1.0g vehicle. We performed 48 hours closed patch test for evaluation of skin safety of HKP-210. Test materials were HKP-210, HKP-210 base, Papsalon G and 0.3% Ketoprofen/pet. Test subjects were 48 out patients with skin diseases who present...
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| Published in | Skin research Vol. 27; no. 3; pp. 375 - 378 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Meeting of Osaka Dermatological Association
1985
日本皮膚科学会大阪地方会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0018-1390 1884-541X |
| DOI | 10.11340/skinresearch1959.27.375 |
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| Abstract | HKP-210 is a anodyne poultics containing 3 mg Ketoprofen in 1.0g vehicle. We performed 48 hours closed patch test for evaluation of skin safety of HKP-210. Test materials were HKP-210, HKP-210 base, Papsalon G and 0.3% Ketoprofen/pet. Test subjects were 48 out patients with skin diseases who presented our clinic during from March to August 1984. Patch test reactions were evaluated according to Japanese standard. The patch test positive rate of Papsalon (>±) was higher than those of HKP-210 and HKP-210 base significantly (p=0.073). The patch test positive rate of Ketoprofen 0.3%/pet was lower than that of Papsalon. So we decided HKP-210 might be used safely being applied correctly. |
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| AbstractList | HKP-210 is a anodyne poultics containing 3 mg Ketoprofen in 1.0g vehicle. We performed 48 hours closed patch test for evaluation of skin safety of HKP-210. Test materials were HKP-210, HKP-210 base, Papsalon G and 0.3% Ketoprofen/pet. Test subjects were 48 out patients with skin diseases who presented our clinic during from March to August 1984. Patch test reactions were evaluated according to Japanese standard. The patch test positive rate of Papsalon (>±) was higher than those of HKP-210 and HKP-210 base significantly (p=0.073). The patch test positive rate of Ketoprofen 0.3%/pet was lower than that of Papsalon. So we decided HKP-210 might be used safely being applied correctly. HKP-210 is a anodyne poultics containing 3 mg Ketoprofen in 1.0g vehicle. We performed 48 hours closed patch test for evaluation of skin safety of HKP-210. Test materials were HKP-210, HKP-210 base, Papsalon G and 0.3% Ketoprofen/pet. Test subjects were 48 out patients with skin diseases who presented our clinic during from March to August 1984. Patch test reactions were evaluated according to Japanese standard. The patch test positive rate of Papsalon (>±) was higher than those of HKP-210 and HKP-210 base significantly (p=0.073). The patch test positive rate of Ketoprofen 0.3%/pet was lower than that of Papsalon. So we decided HKP-210 might be used safely being applied correctly. HKP-210は久光製薬株式会社より開発された消炎鎮痛剤作用を有するケトプロフェンを膏体1g中に3mg含有する経皮吸収型貼付剤で, 整形外科領域の炎症性疼痛性疾患治療薬である。今回我々はHKP-210の皮膚安全性についての検討を依頼されたので名大分院皮膚科を受診した皮膚疾患患者48名を対象に48時間closed patch testを施行した。結果をMann Whitoney U testにより検定した結果48時間の判定時の±以上の陽性率はパップサロンG>HKP-210及び同基剤 (p=0.073) であった。また0.3%ケトプロフェン含有白色ワセリンは既販のパップサロンGに比較して皮膚刺激反応例が有意に少なかった。以上の結果よりHKP-210は整形外科領域に於ける局所治療剤として安全に応用出来る製剤と判定した。 |
| Author | MATSUNAGA, Kayoko HAYAKAWA, Ritsuko |
| Author_FL | 早川 律子 松永 佳世子 |
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| DocumentTitleAlternate | ＨＫＰ‐２１０の皮膚安全性 |
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| References | 1. 中部パッチテスト研究班: Finn-chamber, KIchamber, AL-testの評価, 皮膚, 21: 196-204, 1979. 3. 早川律子, 松永佳世子, 大岩久美子, 請井智香子: KPG-200の皮膚安全性に関する検討, 皮膚, 25: 199-206, 1983. 2. 川村太郎, 笹川正二, 増田勉, 本田史朗, 木下正子, 原田昭太郎, 石崎進, 永井隆吉, 広川浩一, 安西喬, 姉小路公久, 肥田野信, 川野正, 池上一郎, 佐藤重男, 青山卓夫: 貼布試験標準化の基礎的研究, 日皮会誌, 80: 301-314, 1970. |
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| Snippet | HKP-210 is a anodyne poultics containing 3 mg Ketoprofen in 1.0g vehicle. We performed 48 hours closed patch test for evaluation of skin safety of HKP-210.... |
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| SubjectTerms | ケトプロフェン パッチテスト パップ剤 貼付剤 非ステロイド |
| Title | Skin Safety Evaluation of HKP-210 |
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