THE MECHANISM OF DEVELOPMENT OF NASAL MUCOSAL SWELLING IN NASAL ALLERGY
Neural reflex via local and/or central reflexive pathway is only partially involved in development of vasculardilatation and vascular leakage in the nasal mucosa in subjects with nasal allergy. In the pale and edematous nasal mucosa interstitialedema is dominant and blood flow measured by lasor-Dopp...
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| Published in | JIBI INKOKA TEMBO Vol. 39; no. 2; pp. 127 - 136 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Society of Oto-rhino-laryngology Tokyo
1996
耳鼻咽喉科展望会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0386-9687 1883-6429 |
| DOI | 10.11453/orltokyo1958.39.127 |
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| Abstract | Neural reflex via local and/or central reflexive pathway is only partially involved in development of vasculardilatation and vascular leakage in the nasal mucosa in subjects with nasal allergy. In the pale and edematous nasal mucosa interstitialedema is dominant and blood flow measured by lasor-Doppler flowmetry is markedly decreased. Thecapacitance vessel in the edematous nasal mucosa responds poorly to sympathetic stimulation. The marked swelling of the nasal mucosa observed in subjects withnasal allergy is largely caused by the direct effects of a large variety of chemical mediators, such as peptide leukotriens, histamine and PAF, the most important of which is peptide leukotriens, on the nasal vasculature. These chemical mediators interacts among themselves to accentuate their effects on the target organs of the nasalmucosa. The increasing availability of specific receptor antagonists is allowing us to evaluate the role of these chemical mediators in nasal allergy. |
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| AbstractList | Neural reflex via local and/or central reflexive pathway is only partially involved in development of vasculardilatation and vascular leakage in the nasal mucosa in subjects with nasal allergy. In the pale and edematous nasal mucosa interstitialedema is dominant and blood flow measured by lasor-Doppler flowmetry is markedly decreased. Thecapacitance vessel in the edematous nasal mucosa responds poorly to sympathetic stimulation. The marked swelling of the nasal mucosa observed in subjects withnasal allergy is largely caused by the direct effects of a large variety of chemical mediators, such as peptide leukotriens, histamine and PAF, the most important of which is peptide leukotriens, on the nasal vasculature. These chemical mediators interacts among themselves to accentuate their effects on the target organs of the nasalmucosa. The increasing availability of specific receptor antagonists is allowing us to evaluate the role of these chemical mediators in nasal allergy. Neural reflex via local and/or central reflexive pathway is only partially involved in development of vasculardilatation and vascular leakage in the nasal mucosa in subjects with nasal allergy.In the pale and edematous nasal mucosa interstitialedema is dominant and blood flow measured by lasor-Doppler flowmetry is markedly decreased. Thecapacitance vessel in the edematous nasal mucosa responds poorly to sympathetic stimulation. The marked swelling of the nasal mucosa observed in subjects withnasal allergy is largely caused by the direct effects of a large variety of chemical mediators, such as peptide leukotriens, histamine and PAF, the most important of which is peptide leukotriens, on the nasal vasculature.These chemical mediators interacts among themselves to accentuate their effects on the target organs of the nasalmucosa.The increasing availability of specific receptor antagonists is allowing us to evaluate the role of these chemical mediators in nasal allergy. 鼻アレルギーにみられる鼻粘膜の血管拡張および血漿蛋白漏出の発現機序に局所および中枢を介する神経反射は一部関与する。 蒼白浮腫状の鼻粘膜では間質浮腫が著明であり, レーザードップラー血流計で測定した鼻粘膜血流は著明に減少している。また浮腫状の鼻粘膜においては容積血管の交感神経刺激に対する反応は減弱している。鼻アレルギー症例にみられる高度な鼻粘膜腫脹の大部分はペプチドロイコトリエン, ヒスタミン, PAFなど多種類の化学伝達物質の鼻粘膜血管に対する直接作用によるものであり, その中でもペプチドロイコトリエンが最も重要である。これらの化学伝達物質はお互いに作用し合うことによって鼻粘膜の標的器官に対する作用が増幅される。 |
| Author | Terada, Nobuhisa Konno, Akiyoshi Numata, Tsutomu Katahashi, Tatuaki Hanazawa, Toyoyuki |
| Author_FL | 花沢 豊行 沼田 勉 今野 昭義 寺田 修久 片橋 立秋 |
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| References | 16) Konno A, Nagata H, Nomoto M, et al: Role of capsaicin-sensitive trigeminal nerves in development of hyperreactive nasal symptoms in guinea pig model of nasal allergy. Ann Otol Rhinol Laryngol 104: 73-735, 1995. 6) 花澤豊行, 法貴元, 西山真理子, 他: 鼻粘膜血管平滑筋弛緩反応における神経伝達物質, 化学伝達物質およびNOの関与. 頭頸部自律神経10.印刷中. 23) Ishibe T, Yamashita T, Kumazawa T, et al: Adrenergic and cholinergic receptors in human nasal mucosa in cases of nasal allergy. Archs Oto-Rhino-Lar 238: 167-173, 1983. 12) 遊座潤, 今野昭義, 吉田耕, 他: 鼻腔知覚刺激に応答するVidian神経の反射性活動. 頭頸部自律神経10. 19) Konno A, Terada N, Nomoto M: The effect of psychic stimulation upon plasma catecholamine concentrations and nasal patency in patients with nasal allergy. Ann Otol Rhinol Laryngol 103: 375-382, 1994. 24) Konno A, Terada N, Ito E, et al: The reaction of the nasal mucosa to platelet activating factor and leukotriens in nasal allergy. ORL 31 (suppl 7): 241-242, 1987. 15) 星野忠彦: 翼口蓋神経節細胞の電気的特性及びシナプス連絡に関する研究. 秋田医学13: 413, 1991. 18) Konno A, Terada N, Numata T, et al: Comparative rzole of substance P in vascular response of the nasal mucosa in nasal allergy. Ann Otol Rhinol Laryngol, in press. 11) 西山耕一郎: アレルギー性鼻炎における鼻汁中組織カリクレイン活性およびキニンの増大と抑制. 日耳鼻97: 1512-1522, 1994. 17) 片橋立秋, 花澤豊行, 昼間清, 他: タヒキニン受容体拮抗薬がアレルギーモルモット鼻粘膜に与える影響 (会). アレルギー44: 1042, 1995. 20) Konno A, Togawa K, Itasaka Y: Neurophysiological mechanism of shrinkage of nasal mucosa induced by exercise. Auris Nasus Larynx (Tokyo) 9: 81-90, 1982. 10) 山越隆行, 今野昭義, 藤田洋祐, 他: ヒスタミン (H1) 受容体拮抗薬とペプチドロイコトリエン受容体拮抗薬の作用機序の比較検討. 日本鼻科学会会誌33: 320-325, 1995. 13) Konno A, Terada N, Okamoto Y, et al: The role of chemical mediators and mucosal hyperreactivity in nasal hypersecretion in nasal allergy. J Allergy Clin Immunol 79: 620-626, 1987. 14) 谷川博一, 長谷川真也, 山越隆行, 他: 抗原刺激時にみられる反射性鼻粘膜腫脹の経時的変化 (会). アレルギー44: 992, 1995. 2) Hanazawa T, Konno A, Chiba T, et al: Nitric oxide synthase-immunoreactive nerve fibers in the nasal mucosa of the rat. Brain Res 657: 7-13, 1994. 5) 吉田耕, 中沢健, 花澤豊行, 他: ネコ上唾液核刺激が鼻粘膜血管透過性に与える影響 (会). 日本鼻科学会会誌34: 181, 1995. 22) 安藤英樹, 寺田修久, 戸川清, 他: 鼻過敏症症例鼻粘膜における自律神経受容体数と鼻症状との相関性について. 日耳鼻92: 183-188, 1989. 4) 吉田耕, 柴啓介, 中沢健, 他: ネコ上唾液核刺激による鼻粘膜血流量・鼻腔通気度変化 (会). 日耳鼻98: 1578, 1995. 8) 寺田修久, 今野昭義, 安藤英樹, 他: 鼻アレルギーとロイコトリエン (第2報) 抗原誘発後の鼻腔洗浄液におけるペプチドロイコトリエンおよび炎症細胞の経時変化. 日耳鼻92: 1337-1344, 1989. 21) Konno A, Terada N, Okamoto Y: Changes of adrenergic and Cholinergic muscarinic receptors in nasal mucosa in nasal allergy. ORL 49: 103-111, 1987. 1) Lundblad L, Lundberg JM, Brodin E, et al: Origin and distribution of capsaicin-sensitive substance Pimmunoreactive nerves in the nasal mucosa. Acta Otolaryngol 96: 485-493, 1983. 7) 花沢豊行, 今野昭義, 西山真理子, 他: 鼻アレルギーとNO. 気道アレルギー'95-気管支喘息とアレルギー性鼻炎-. 牧野荘平, 石川障監修: メディカルビュー社, 東京, 1995, 41-50. 3) Motosugi H, Chiba T, Konno A, et al: Distribution of neuropeptides in rat pterygopalatine ganglion: light and electron microscopic immunohistochemical studies. Arch Histol Cytol 55: 513, 1992. 9) 今野昭義, 寺田修久, 花沢豊行, 他: 通年性鼻アレルギー症例における抗原誘発後の鼻洗浄液中ブラジキニン濃度の経時的変化と抗原誘発鼻粘膜反応に対するブラジキニン受容体拮抗薬 (HOE 140) の作用. |
| References_xml | – reference: 17) 片橋立秋, 花澤豊行, 昼間清, 他: タヒキニン受容体拮抗薬がアレルギーモルモット鼻粘膜に与える影響 (会). アレルギー44: 1042, 1995. – reference: 12) 遊座潤, 今野昭義, 吉田耕, 他: 鼻腔知覚刺激に応答するVidian神経の反射性活動. 頭頸部自律神経10. – reference: 14) 谷川博一, 長谷川真也, 山越隆行, 他: 抗原刺激時にみられる反射性鼻粘膜腫脹の経時的変化 (会). アレルギー44: 992, 1995. – reference: 9) 今野昭義, 寺田修久, 花沢豊行, 他: 通年性鼻アレルギー症例における抗原誘発後の鼻洗浄液中ブラジキニン濃度の経時的変化と抗原誘発鼻粘膜反応に対するブラジキニン受容体拮抗薬 (HOE 140) の作用. – reference: 2) Hanazawa T, Konno A, Chiba T, et al: Nitric oxide synthase-immunoreactive nerve fibers in the nasal mucosa of the rat. Brain Res 657: 7-13, 1994. – reference: 7) 花沢豊行, 今野昭義, 西山真理子, 他: 鼻アレルギーとNO. 気道アレルギー'95-気管支喘息とアレルギー性鼻炎-. 牧野荘平, 石川障監修: メディカルビュー社, 東京, 1995, 41-50. – reference: 5) 吉田耕, 中沢健, 花澤豊行, 他: ネコ上唾液核刺激が鼻粘膜血管透過性に与える影響 (会). 日本鼻科学会会誌34: 181, 1995. – reference: 13) Konno A, Terada N, Okamoto Y, et al: The role of chemical mediators and mucosal hyperreactivity in nasal hypersecretion in nasal allergy. J Allergy Clin Immunol 79: 620-626, 1987. – reference: 19) Konno A, Terada N, Nomoto M: The effect of psychic stimulation upon plasma catecholamine concentrations and nasal patency in patients with nasal allergy. Ann Otol Rhinol Laryngol 103: 375-382, 1994. – reference: 23) Ishibe T, Yamashita T, Kumazawa T, et al: Adrenergic and cholinergic receptors in human nasal mucosa in cases of nasal allergy. Archs Oto-Rhino-Lar 238: 167-173, 1983. – reference: 16) Konno A, Nagata H, Nomoto M, et al: Role of capsaicin-sensitive trigeminal nerves in development of hyperreactive nasal symptoms in guinea pig model of nasal allergy. Ann Otol Rhinol Laryngol 104: 73-735, 1995. – reference: 15) 星野忠彦: 翼口蓋神経節細胞の電気的特性及びシナプス連絡に関する研究. 秋田医学13: 413, 1991. – reference: 20) Konno A, Togawa K, Itasaka Y: Neurophysiological mechanism of shrinkage of nasal mucosa induced by exercise. Auris Nasus Larynx (Tokyo) 9: 81-90, 1982. – reference: 18) Konno A, Terada N, Numata T, et al: Comparative rzole of substance P in vascular response of the nasal mucosa in nasal allergy. Ann Otol Rhinol Laryngol, in press. – reference: 21) Konno A, Terada N, Okamoto Y: Changes of adrenergic and Cholinergic muscarinic receptors in nasal mucosa in nasal allergy. ORL 49: 103-111, 1987. – reference: 6) 花澤豊行, 法貴元, 西山真理子, 他: 鼻粘膜血管平滑筋弛緩反応における神経伝達物質, 化学伝達物質およびNOの関与. 頭頸部自律神経10.印刷中. – reference: 8) 寺田修久, 今野昭義, 安藤英樹, 他: 鼻アレルギーとロイコトリエン (第2報) 抗原誘発後の鼻腔洗浄液におけるペプチドロイコトリエンおよび炎症細胞の経時変化. 日耳鼻92: 1337-1344, 1989. – reference: 24) Konno A, Terada N, Ito E, et al: The reaction of the nasal mucosa to platelet activating factor and leukotriens in nasal allergy. ORL 31 (suppl 7): 241-242, 1987. – reference: 11) 西山耕一郎: アレルギー性鼻炎における鼻汁中組織カリクレイン活性およびキニンの増大と抑制. 日耳鼻97: 1512-1522, 1994. – reference: 4) 吉田耕, 柴啓介, 中沢健, 他: ネコ上唾液核刺激による鼻粘膜血流量・鼻腔通気度変化 (会). 日耳鼻98: 1578, 1995. – reference: 22) 安藤英樹, 寺田修久, 戸川清, 他: 鼻過敏症症例鼻粘膜における自律神経受容体数と鼻症状との相関性について. 日耳鼻92: 183-188, 1989. – reference: 1) Lundblad L, Lundberg JM, Brodin E, et al: Origin and distribution of capsaicin-sensitive substance Pimmunoreactive nerves in the nasal mucosa. Acta Otolaryngol 96: 485-493, 1983. – reference: 3) Motosugi H, Chiba T, Konno A, et al: Distribution of neuropeptides in rat pterygopalatine ganglion: light and electron microscopic immunohistochemical studies. Arch Histol Cytol 55: 513, 1992. – reference: 10) 山越隆行, 今野昭義, 藤田洋祐, 他: ヒスタミン (H1) 受容体拮抗薬とペプチドロイコトリエン受容体拮抗薬の作用機序の比較検討. 日本鼻科学会会誌33: 320-325, 1995. |
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| Title | THE MECHANISM OF DEVELOPMENT OF NASAL MUCOSAL SWELLING IN NASAL ALLERGY |
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