THE MECHANISM OF DEVELOPMENT OF NASAL MUCOSAL SWELLING IN NASAL ALLERGY

Neural reflex via local and/or central reflexive pathway is only partially involved in development of vasculardilatation and vascular leakage in the nasal mucosa in subjects with nasal allergy. In the pale and edematous nasal mucosa interstitialedema is dominant and blood flow measured by lasor-Dopp...

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Published inJIBI INKOKA TEMBO Vol. 39; no. 2; pp. 127 - 136
Main Authors Konno, Akiyoshi, Terada, Nobuhisa, Katahashi, Tatuaki, Numata, Tsutomu, Hanazawa, Toyoyuki
Format Journal Article
LanguageJapanese
Published Society of Oto-rhino-laryngology Tokyo 1996
耳鼻咽喉科展望会
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ISSN0386-9687
1883-6429
DOI10.11453/orltokyo1958.39.127

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Summary:Neural reflex via local and/or central reflexive pathway is only partially involved in development of vasculardilatation and vascular leakage in the nasal mucosa in subjects with nasal allergy. In the pale and edematous nasal mucosa interstitialedema is dominant and blood flow measured by lasor-Doppler flowmetry is markedly decreased. Thecapacitance vessel in the edematous nasal mucosa responds poorly to sympathetic stimulation. The marked swelling of the nasal mucosa observed in subjects withnasal allergy is largely caused by the direct effects of a large variety of chemical mediators, such as peptide leukotriens, histamine and PAF, the most important of which is peptide leukotriens, on the nasal vasculature. These chemical mediators interacts among themselves to accentuate their effects on the target organs of the nasalmucosa. The increasing availability of specific receptor antagonists is allowing us to evaluate the role of these chemical mediators in nasal allergy.
ISSN:0386-9687
1883-6429
DOI:10.11453/orltokyo1958.39.127