A CLINICAL STUDY AND DETERMINATION OF THE TONSILLAR LEVEL OF CEFACLOR IN PEDIATRIC FIELD

Cefaclor (CCL), a new oral cephalosporin, was administered to 18 children with various infections. The efficacy rate was 77.8%. CCL was effective especially for infections caused by E. coli, P. mirabilis and S. aureus, and in a case of urinary tract infection caused by Enterobacter cloacae. Side eff...

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Published inCHEMOTHERAPY Vol. 27; no. Supplement7; pp. 344 - 347
Main Authors AOYAMA, RYUZO, IZUMI, YUKIO, NAGATA, KISHIRO
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1979
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ISSN0009-3165
1884-5894
DOI10.11250/chemotherapy1953.27.Supplement7_344

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Summary:Cefaclor (CCL), a new oral cephalosporin, was administered to 18 children with various infections. The efficacy rate was 77.8%. CCL was effective especially for infections caused by E. coli, P. mirabilis and S. aureus, and in a case of urinary tract infection caused by Enterobacter cloacae. Side effect was observed only in one case whose serum GOT and GPT were both elevated but were normalized after discontinuation of CCL for 6 days. A 15 years old boy with chronic tonsillitis was administered 500 mg of CCL every 8 hours, and his tonsillar level of CCL was determined at tonsillectomy. The tonsillar level of CCL was 8.0 μg/g at 2 hours after administration of CCL.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.27.Supplement7_344