THE EFFECTS OF A IONG-TERM AND LOW DOSE ADMINISTRATION OF CLARITHROMYCIN IN CHRONIC SINUSITIS

This study was designed to evaluate the effectiveness of a long-term and low dose administration of Clarithromycin (CAM) in chronic sinusitis (CS). The subjects of this study were 75 patients with CS aged more than 16 years old. Fifty-eight patients were administered 200 mg of CAM per day for 3 or 6...

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Published inJIBI INKOKA TEMBO Vol. 40; no. Supplement2; pp. 126 - 132
Main Authors Sakakura, Yasuo, Majima, Yuichi
Format Journal Article
LanguageEnglish
Japanese
Published Society of Oto-rhino-laryngology Tokyo 1997
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ISSN0386-9687
1883-6429
DOI10.11453/orltokyo1958.40.Supplement2_126

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Summary:This study was designed to evaluate the effectiveness of a long-term and low dose administration of Clarithromycin (CAM) in chronic sinusitis (CS). The subjects of this study were 75 patients with CS aged more than 16 years old. Fifty-eight patients were administered 200 mg of CAM per day for 3 or 6 months. Seventeen patients received 600 mg of Erythromycin (EM) per day for 3 months. The overall clinical efficacy determined by subjective symptoms and rhinoscopic observations was classified into excellent, good, fair, poor and worse categories. The general effectiveness that includes both excellent and good categories was tending to increase up to the 3 months of the administration period of CAM. The similar observation was exist in the EM administration. On the 3 months of administration period, the general effectiveness of CAM and EM was 44.5% and 25.0% respectively, and this difference was not statistically significant. The general effectiveness of CAM was discussed in relation to that of other therapeutic methods for CS.
ISSN:0386-9687
1883-6429
DOI:10.11453/orltokyo1958.40.Supplement2_126