味刺激が成人の下行性痛覚調節系に及ぼす影響
本研究は甘味刺激による穿刺痛への鎮痛効果と下行性痛覚調節系に及ぼす影響を明らかにするため，Singlemasked blind による無作為化比較試験で検証した。実験は健康成人12名を対象に，24 %蔗糖水と蒸留水（control）の２つを準備し，クロスオーバーデザインによって被験者に無作為に割り付けた。指標には血清セロトニン，尿中セロトニン代謝物質，唾液中α-アミラーゼ，Profile of mood states，痛覚強度と味の心地よさの各主観的評価を採用して，甘味による鎮痛効果と下行性疼痛抑制系への影響を多角的に検討した。 しかしながら，甘味刺激による穿刺痛への効果と下行性疼痛抑制系へ...
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| Published in | 日本看護研究学会雑誌 Vol. 34; no. 2; pp. 2_163 - 2_170 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本看護研究学会
2011
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2188-3599 2189-6100 |
| DOI | 10.15065/jjsnr.20110411015 |
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| Abstract | 本研究は甘味刺激による穿刺痛への鎮痛効果と下行性痛覚調節系に及ぼす影響を明らかにするため，Singlemasked blind による無作為化比較試験で検証した。実験は健康成人12名を対象に，24 %蔗糖水と蒸留水（control）の２つを準備し，クロスオーバーデザインによって被験者に無作為に割り付けた。指標には血清セロトニン，尿中セロトニン代謝物質，唾液中α-アミラーゼ，Profile of mood states，痛覚強度と味の心地よさの各主観的評価を採用して，甘味による鎮痛効果と下行性疼痛抑制系への影響を多角的に検討した。 しかしながら，甘味刺激による穿刺痛への効果と下行性疼痛抑制系への賦活作用については，いずれも実証することはできなかった。ただし，甘味刺激下では無味に比べて穿刺痛の痛覚強度や唾液中α-アミラーゼ値がいずれも低値になるだけでなく，Profile of mood states や溶液の味の心地よさの各評価に関してはポジティブな情動的変化がもたらされた。よって，限定的ではあるものの，甘味刺激は成人の痛覚受容を抑制的に修飾する可能性がある。 |
|---|---|
| AbstractList | 本研究は甘味刺激による穿刺痛への鎮痛効果と下行性痛覚調節系に及ぼす影響を明らかにするため，Singlemasked blind による無作為化比較試験で検証した。実験は健康成人12名を対象に，24 %蔗糖水と蒸留水（control）の２つを準備し，クロスオーバーデザインによって被験者に無作為に割り付けた。指標には血清セロトニン，尿中セロトニン代謝物質，唾液中α-アミラーゼ，Profile of mood states，痛覚強度と味の心地よさの各主観的評価を採用して，甘味による鎮痛効果と下行性疼痛抑制系への影響を多角的に検討した。 しかしながら，甘味刺激による穿刺痛への効果と下行性疼痛抑制系への賦活作用については，いずれも実証することはできなかった。ただし，甘味刺激下では無味に比べて穿刺痛の痛覚強度や唾液中α-アミラーゼ値がいずれも低値になるだけでなく，Profile of mood states や溶液の味の心地よさの各評価に関してはポジティブな情動的変化がもたらされた。よって，限定的ではあるものの，甘味刺激は成人の痛覚受容を抑制的に修飾する可能性がある。 |
| Author | 掛田, 崇寛 |
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| References | 9) Acharya, A.B., Annamali, S., et al.: Oral sucrose analgesia for preterm infant venepuncture, Arch. Dis. Child. Fetal. Neonatal Ed., 89, F17-F18, 2004. 26) Takai, N., Yamaguchi, M., et al.: Effect of psychological stress on the salivary cortisol and amylase levels in healthy young adults, Arch. Oral Biol., 49, 963-968, 2004. 13) Barr, R.G., Quek, V. et al.: Effects of intra-oral sucrose on crying, mouthing and hang-mouth contact in newborn and six-week-old infants, Dev. Med. Child Neurol., 36, 608-618, 1994. 3) Segato, F. N., Castro-Souza, C., et al.: Sucrose ingestion causes opioid analgesia, Braz. J. Med. Biol. Res., 30, 981-984, 1997. 10) Stevens, B., Taddio, A., et al.: The efficacy of sucrose for relieving procedural pain in neonates-a systematic review and meta-analysis, Acta Paediatr., 86, 837-842, 1997. 23) Stevens, B., Yamada, J., et al.: Sucrose for analgesia in newborn infants undergoing painful procedures, Cochrane Database Syst. Rev., CD001069, 2010. 5) Blass, E.M., Hoffmeyer, L.B.: Sucrose as an analgesic for newborn infants, Pediatrics, 87, 215-218, 1991. 6) Haouari, N., Wood, C., et al.: The analgesic effect of sucrose in full term infants: a randomized controlled trial, BMJ, 310, 1498-1500, 1995. 20) Kakeda, T.: Potential of sucrose-induced analgesia to relieve pain in male adults: A preliminary study, Jpn. J. Nurs. Sci., 7, 169-173, 2010. 12) Blass, E.M., Shah, A.: Pain-reducing properties of sucrose in human newborn, Chem. Senses, 20, 29-35, 1995. 7) Herschel, M., Khoshnood, B., et al.: Neonatal circumcision. Randomized trial of a sucrose pacifier for pain control, Arch. Pediatr.Adolesc. Med., 152, 279-284, 1998. 17) Kanarek, R.B., Carrington, C.: Sucrose consumption enhances the analgesic effects of cigarette smoking in male and female smokers, Psychopharmacology, 173, 57-63, 2004. 8) Ramenghi, L.A., Wood, C.M., et al.: Reduction of pain response in premature infants using intraoral sucrose, Arch. Dis. Child. Fetal. Neonatal Ed., 74, F126-F128, 1996. 1) Gibbins, S., Stevens, B.: Mechanisms of sucrose and non-nutritive sucking in procedural pain management in infants, Pain Res. Manag, 6, 21-28, 2001. 25) Wakayama, K., Ohtsuki, S., et al.: Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells, Neurosci. Res., 44, 173-180, 2002. 21) Kakeda, T., Ogino, Y., et al.: Sweet taste induced analgesia: an fMRI study. Neuroreport, 21, 427-431, 2010. 30) Kakeda, T., Ishikawa T.: Gender differences in pain modulation on nociception by sweet stimulus in adults: a randomized study, Nurs. Health Sci., 13, 34-40, 2011. 16) Lewkowski, M.D., Ditto, B., et al.: Sweet taste and blood pressure-related analgesia, Pain, 106, 181-186, 2003. 4) Dutta, R., Mukherjee, K., et al.: Effect of VMH lesion on sucrose-fed analgesia in formalin pain, Jpn. J. Physiol., 51, 63-69, 2001. 19) Kakeda, T., Ito, M., et al.: The evidence for sweet substance-induced analgesia in adult human, Pain Res., 23, 159-166, 2008. 28) Taddio, A., Shah, V., et al.: β-endorphin concentration after administration of sucrose in preterm infants, Arch. Pediatr. Adolesc. Med., 157, 1071-1074, 2003. 15) Mercer, M.E., Holder, M.D.: Antinociceptive effects of palatable sweet ingesta on human responsivity to pressure pain, Physiol. Behav., 61, 311-318, 1997. 18) Pepino, M.Y., Mennella, J.A.: Sucrose-induced analgesia is related to sweet preferences in children but not adults, Pain, 119, 210-218, 2005. 14) Anseloni, V.C., Weng, H.R., et al.: Age-dependency of analgesia elicited by intraoral sucrose in acute and persistent pain models, Pain, 97, 93-103, 2002. 27) 横山和仁: POMS短縮版手引と事例解説, 金子書房, 東京, 2006. 11) Ramenghi, L.A., Evans, D.J., et al.: "Sucrose analgesia": absorptive mechanism or taste perception? , Arch. Dis. Child. Fetal. Neonatal Ed., 80, F146-F147, 1999. 2) Dum, J., Gramsch, C., et al.: Activation of hypothalamic beta endorphin pools by reward induced by high palatable food, Pharmacol. Biochem. Behav., 58, 443-447, 1983. 22) Bandler, R., Shipley, M.T.: Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? , Trends Neurosci., 17, 379-389, 1994. 24) Terasaki, T., Hosoya, K.: The blood-brain barrier efflux transporters as a detoxifying system for the brain, Adv. Drug Deliv. Rev., 36, 195-209, 1999. 29) O'Doherty, J., Rolls, E.T., et al.: Representation of pleasant and aversive taste in the human brain, J. Neurophysiol., 85, 1315-21, 2001. |
| References_xml | – reference: 29) O'Doherty, J., Rolls, E.T., et al.: Representation of pleasant and aversive taste in the human brain, J. Neurophysiol., 85, 1315-21, 2001. – reference: 24) Terasaki, T., Hosoya, K.: The blood-brain barrier efflux transporters as a detoxifying system for the brain, Adv. Drug Deliv. Rev., 36, 195-209, 1999. – reference: 14) Anseloni, V.C., Weng, H.R., et al.: Age-dependency of analgesia elicited by intraoral sucrose in acute and persistent pain models, Pain, 97, 93-103, 2002. – reference: 17) Kanarek, R.B., Carrington, C.: Sucrose consumption enhances the analgesic effects of cigarette smoking in male and female smokers, Psychopharmacology, 173, 57-63, 2004. – reference: 1) Gibbins, S., Stevens, B.: Mechanisms of sucrose and non-nutritive sucking in procedural pain management in infants, Pain Res. Manag, 6, 21-28, 2001. – reference: 23) Stevens, B., Yamada, J., et al.: Sucrose for analgesia in newborn infants undergoing painful procedures, Cochrane Database Syst. Rev., CD001069, 2010. – reference: 12) Blass, E.M., Shah, A.: Pain-reducing properties of sucrose in human newborn, Chem. Senses, 20, 29-35, 1995. – reference: 7) Herschel, M., Khoshnood, B., et al.: Neonatal circumcision. Randomized trial of a sucrose pacifier for pain control, Arch. Pediatr.Adolesc. Med., 152, 279-284, 1998. – reference: 22) Bandler, R., Shipley, M.T.: Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? , Trends Neurosci., 17, 379-389, 1994. – reference: 26) Takai, N., Yamaguchi, M., et al.: Effect of psychological stress on the salivary cortisol and amylase levels in healthy young adults, Arch. Oral Biol., 49, 963-968, 2004. – reference: 10) Stevens, B., Taddio, A., et al.: The efficacy of sucrose for relieving procedural pain in neonates-a systematic review and meta-analysis, Acta Paediatr., 86, 837-842, 1997. – reference: 15) Mercer, M.E., Holder, M.D.: Antinociceptive effects of palatable sweet ingesta on human responsivity to pressure pain, Physiol. Behav., 61, 311-318, 1997. – reference: 16) Lewkowski, M.D., Ditto, B., et al.: Sweet taste and blood pressure-related analgesia, Pain, 106, 181-186, 2003. – reference: 18) Pepino, M.Y., Mennella, J.A.: Sucrose-induced analgesia is related to sweet preferences in children but not adults, Pain, 119, 210-218, 2005. – reference: 19) Kakeda, T., Ito, M., et al.: The evidence for sweet substance-induced analgesia in adult human, Pain Res., 23, 159-166, 2008. – reference: 2) Dum, J., Gramsch, C., et al.: Activation of hypothalamic beta endorphin pools by reward induced by high palatable food, Pharmacol. Biochem. Behav., 58, 443-447, 1983. – reference: 11) Ramenghi, L.A., Evans, D.J., et al.: "Sucrose analgesia": absorptive mechanism or taste perception? , Arch. Dis. Child. Fetal. Neonatal Ed., 80, F146-F147, 1999. – reference: 20) Kakeda, T.: Potential of sucrose-induced analgesia to relieve pain in male adults: A preliminary study, Jpn. J. Nurs. Sci., 7, 169-173, 2010. – reference: 8) Ramenghi, L.A., Wood, C.M., et al.: Reduction of pain response in premature infants using intraoral sucrose, Arch. Dis. Child. Fetal. Neonatal Ed., 74, F126-F128, 1996. – reference: 4) Dutta, R., Mukherjee, K., et al.: Effect of VMH lesion on sucrose-fed analgesia in formalin pain, Jpn. J. Physiol., 51, 63-69, 2001. – reference: 3) Segato, F. N., Castro-Souza, C., et al.: Sucrose ingestion causes opioid analgesia, Braz. J. Med. Biol. Res., 30, 981-984, 1997. – reference: 13) Barr, R.G., Quek, V. et al.: Effects of intra-oral sucrose on crying, mouthing and hang-mouth contact in newborn and six-week-old infants, Dev. Med. Child Neurol., 36, 608-618, 1994. – reference: 25) Wakayama, K., Ohtsuki, S., et al.: Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells, Neurosci. Res., 44, 173-180, 2002. – reference: 28) Taddio, A., Shah, V., et al.: β-endorphin concentration after administration of sucrose in preterm infants, Arch. Pediatr. Adolesc. Med., 157, 1071-1074, 2003. – reference: 9) Acharya, A.B., Annamali, S., et al.: Oral sucrose analgesia for preterm infant venepuncture, Arch. Dis. Child. Fetal. Neonatal Ed., 89, F17-F18, 2004. – reference: 21) Kakeda, T., Ogino, Y., et al.: Sweet taste induced analgesia: an fMRI study. Neuroreport, 21, 427-431, 2010. – reference: 6) Haouari, N., Wood, C., et al.: The analgesic effect of sucrose in full term infants: a randomized controlled trial, BMJ, 310, 1498-1500, 1995. – reference: 5) Blass, E.M., Hoffmeyer, L.B.: Sucrose as an analgesic for newborn infants, Pediatrics, 87, 215-218, 1991. – reference: 27) 横山和仁: POMS短縮版手引と事例解説, 金子書房, 東京, 2006. – reference: 30) Kakeda, T., Ishikawa T.: Gender differences in pain modulation on nociception by sweet stimulus in adults: a randomized study, Nurs. Health Sci., 13, 34-40, 2011. |
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| Snippet | 本研究は甘味刺激による穿刺痛への鎮痛効果と下行性痛覚調節系に及ぼす影響を明らかにするため，Singlemasked blind による無作為化比較試験で検証した。実験は健康成人12... |
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| SubjectTerms | ヒト 甘味 疼痛 鎮痛 |
| Title | 味刺激が成人の下行性痛覚調節系に及ぼす影響 |
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