口腔扁平上皮癌患者の予後に対する術前低予後栄養指数および高筋肉内脂肪含有量の影響

• Published in: 日本口腔外科学会雑誌 Vol. 67; no. 6; pp. 410 - 416
• Main Authors: 東, 翔太朗, 吉村, 卓也, 石田, 喬之, 中村, 典史, 鈴木, 甫, 中村, 康典, 高山, 大生, 平野, 憂花, 野添, 悦郎, 手塚, 征宏
• Format: Journal Article
• Language: Japanese
• Published: 社団法人 日本口腔外科学会 20.06.2021
• Subjects: コンピューター断層撮影; サルコペニア; 口腔扁平上皮癌; 筋肉内脂肪含有量; 腸腰筋指数
• ISSN: 0021-5163; 2186-1579
• DOI: 10.5794/jjoms.67.410

The impact of preoperative malnutrition and sarcopenia on survival in oral squamous cell carcinoma (OSCC) patients remains controversial. We investigated the effects of preoperative nutritional status and abnormalities in body composition on the mortality of OSCC patients. A retrospective study involving 103 patients with OSCC was conducted. Disease-specific survival (DSS) according to the preoperative psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC) was evaluated. Univariate and multivariate analyses were performed to determine the predictive performance of the covariates with respect to DSS. The DSS rate in patients with high IMAC and low PMI was significantly lower than in controls. Multivariate analysis revealed that a low preoperative Prognostic Nutritional Index (PNI) and high IMAC were independent risk factors. We demonstrated that preoperative malnutrition and abnormal body composition, such as preoperative skeletal muscle quality, are associated with DSS in OSCC patients. Our study suggests that the evaluation of preoperative malnutrition and skeletal muscle quality would be useful for predicting mortality in patients with OSCC.