糖尿病・慢性腎臓病と歯周病の関連 そのメカニズム解析と歯周治療への応用の展望
「はじめに」 歯周病は全身状態や内科疾患と密接な関連を有していることが明らかにされてきており, ペリオドンタルメディシンという概念の下で研究が進められている. 特に糖尿病との関連が双方向性に密接であることは十分にコンセンサスが得られているが, いまだその機序において明らかになっていない点がある. また, 糖尿病合併症として関連する慢性腎臓病と歯周病の関係性については不明なことが多い. 本稿では, インスリン抵抗性や酸化ストレスを中心に, それらの関係性を概説する. 「歯周組織におけるインスリン抵抗性の発現」 歯周病と糖尿病が相互に影響を及ぼし合うことは, 疫学的調査や介入研究により広く認識され...
Saved in:
| Published in | 日本歯科保存学雑誌 Vol. 65; no. 1; pp. 25 - 29 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本歯科保存学会
28.02.2022
日本歯科保存学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0387-2343 2188-0808 |
| DOI | 10.11471/shikahozon.65.25 |
Cover
| Abstract | 「はじめに」 歯周病は全身状態や内科疾患と密接な関連を有していることが明らかにされてきており, ペリオドンタルメディシンという概念の下で研究が進められている. 特に糖尿病との関連が双方向性に密接であることは十分にコンセンサスが得られているが, いまだその機序において明らかになっていない点がある. また, 糖尿病合併症として関連する慢性腎臓病と歯周病の関係性については不明なことが多い. 本稿では, インスリン抵抗性や酸化ストレスを中心に, それらの関係性を概説する. 「歯周組織におけるインスリン抵抗性の発現」 歯周病と糖尿病が相互に影響を及ぼし合うことは, 疫学的調査や介入研究により広く認識されており, さまざまなメカニズムが示されている. 糖尿病の定義である「慢性的な高血糖状態」がインスリン抵抗性を生じ, 主要な糖尿病慢性合併症の発症に強くかかわっていることが知られている. |
|---|---|
| AbstractList | 「はじめに」 歯周病は全身状態や内科疾患と密接な関連を有していることが明らかにされてきており, ペリオドンタルメディシンという概念の下で研究が進められている. 特に糖尿病との関連が双方向性に密接であることは十分にコンセンサスが得られているが, いまだその機序において明らかになっていない点がある. また, 糖尿病合併症として関連する慢性腎臓病と歯周病の関係性については不明なことが多い. 本稿では, インスリン抵抗性や酸化ストレスを中心に, それらの関係性を概説する. 「歯周組織におけるインスリン抵抗性の発現」 歯周病と糖尿病が相互に影響を及ぼし合うことは, 疫学的調査や介入研究により広く認識されており, さまざまなメカニズムが示されている. 糖尿病の定義である「慢性的な高血糖状態」がインスリン抵抗性を生じ, 主要な糖尿病慢性合併症の発症に強くかかわっていることが知られている. |
| Author | 水谷, 幸嗣 |
| Author_xml | – sequence: 1 fullname: 水谷, 幸嗣 organization: 東京医科歯科大学大学院医歯学総合研究科 歯周病学分野 |
| BookMark | eNpFkM1Kw0AUhQdRsNY-gA-RemfuTDJZStEqFNzoephmJjaxTSSpC11VpLgTRKj7urAbf8ClCx9G-vcWplZxcc-5nAvfgbtBVpM0sYRsUahSyj26nbeiU91KL9Ok6ooqEyukxKiUDkiQq6QEKD2HIcd1UsnzGACQoeuhXyIwfR-M3z6nD_2v649JfzjpPc36t7Ob-0VyNZo8v47vRj_7y3wwnPceN8laqNu5rfx6mRzv7R7V9p3GYf2gttNwYgaCOYhodFPoELjhxlKkAUojXBtw6YHm1g1daQMPRNNKZMLXoc-t4VyIIvQAy6S-5HasiQLdTpN2lFgVp-dZUvQqk9IgTYxVDBhTAK4AWhgvhomF-Oj7IDgrSLUlKc67-sSqsyzq6OxC6awbBW2r_p-nXKHoQgrC3zVo6UzFGr8BIMl8bg |
| ContentType | Journal Article |
| Copyright | 2022 特定非営利活動法人日本歯科保存学会 |
| Copyright_xml | – notice: 2022 特定非営利活動法人日本歯科保存学会 |
| CorporateAuthor | 東京医科歯科大学大学院医歯学総合研究科 歯周病学分野 |
| CorporateAuthor_xml | – name: 東京医科歯科大学大学院医歯学総合研究科 歯周病学分野 |
| DOI | 10.11471/shikahozon.65.25 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2188-0808 |
| EndPage | 29 |
| ExternalDocumentID | do1conde_2022_006501_004_0025_00293990542 article_shikahozon_65_1_65_25_article_char_ja |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSF KQ8 MOJWN RJT |
| ID | FETCH-LOGICAL-j2052-333dab5af04d4de131c38d56ec4870a4e6f68ec705be83259af94ed4455c70703 |
| ISSN | 0387-2343 |
| IngestDate | Thu Jul 10 16:15:00 EDT 2025 Wed Sep 03 06:30:48 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 1 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j2052-333dab5af04d4de131c38d56ec4870a4e6f68ec705be83259af94ed4455c70703 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/shikahozon/65/1/65_25/_article/-char/ja |
| PageCount | 5 |
| ParticipantIDs | medicalonline_journals_do1conde_2022_006501_004_0025_00293990542 jstage_primary_article_shikahozon_65_1_65_25_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 2022/02/28 20220228 |
| PublicationDateYYYYMMDD | 2022-02-28 |
| PublicationDate_xml | – month: 02 year: 2022 text: 2022/02/28 day: 28 |
| PublicationDecade | 2020 |
| PublicationTitle | 日本歯科保存学雑誌 |
| PublicationTitleAlternate | 日歯保存誌 |
| PublicationYear | 2022 |
| Publisher | 特定非営利活動法人 日本歯科保存学会 日本歯科保存学会 |
| Publisher_xml | – name: 特定非営利活動法人 日本歯科保存学会 – name: 日本歯科保存学会 |
| References | 3) Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol 2011; 7: 738-748. 7) Buranasin P, Mizutani K, Iwasaki K, Pawaputanon Na Mahasarakham C, Kido D, Takeda K, Izumi Y. High glucose-induced oxidative stress impairs proliferation and migration of human gingival fibroblasts. PLoS One 2018; 13: e0201855. 13) Takeda K, Mizutani K, Matsuura T, Kido D, Mikami R, Noda M, Buranasin P, Sasaki Y, Izumi Y. Periodontal regenerative effect of enamel matrix derivative in diabetes. PLoS One 2018; 13: e0207201. 16) 水谷幸嗣, 三上理沙子, 松浦孝典, 和泉雄一, 岩田隆紀, 青木 章. 低侵襲の歯周外科治療にEr : YAGレーザーを応用した症例の長期経過. 日歯保存誌 2020 ; 63 : 96-104. 18) Mikami R, Mizutani K, Gohda T, Gotoh H, Matsuyama Y, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Fujiwara T, Iwata T. Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study. Clin Exp Nephrol 2021; 25: 58-65. 11) Mizutani K, Buranasin P, Mikami R, Takeda K, Kido D, Watanabe K, Takemura S, Nakagawa K, Kominato H, Saito N, Hattori A, Iwata T. Effects of antioxidant in adjunct with periodontal therapy in patients with type 2 diabetes: A systematic review and meta-analysis. Antioxidants (Basel) 2021; 10. 4) Rask-Madsen C, Kahn CR. Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol 2012; 32: 2052-2059. 12) Kao RT, Nares S, Reynolds MA. Periodontal regeneration―intrabony defects: a systematic review from the AAP Regeneration Workshop. J Periodontol 2015; 86: S77-104. 9) Kominato H, Takeda K, Mizutani K, Mikami R, Kido D, Buranasin P, Saito N, Takemura S, Nakagawa K, Nagasawa T, Iwata T. Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin-resistant prediabetes mice. J Periodontol 2021. (in press 15) Mizutani K, Shioyama H, Matsuura T, Mikami R, Takeda K, Izumi Y, Aoki A, Iwata T. Periodontal regenerative therapy in patients with type 2 diabetes using minimally invasive surgical technique with enamel matrix derivative under 3-year observation: A prospective cohort study. J Periodontol 2021; 92: 1262-1273. 19) Mizutani K, Mikami R, Gohda T, Gotoh H, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Sasaki Y, Iwata T. Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study. Sci Rep 2020; 10: 21872. 6) Mizutani K, Park K, Mima A, Katagiri S, King GL. Obesity-associated gingival vascular inflammation and insulin resistance. J Dent Res 2014; 93: 596-601. 8) Kido D, Mizutani K, Takeda K, Mikami R, Matsuura T, Iwasaki K, Izumi Y. Impact of diabetes on gingival wound healing via oxidative stress. PLoS One 2017; 12: e0189601. 14) Takeda K, Mizutani K, Matsuura T, Kido D, Mikami R, Buranasin P, Saito N, Kominato H, Takemura S, Nakagawa K, Iwata T. Antioxidant effect of enamel matrix derivative for early phase of periodontal tissue regeneration in diabetes. J Periodontol 2021. (in press 20) Takeda K, Mizutani K, Minami I, Kido D, Mikami R, Konuma K, Saito N, Kominato H, Takemura S, Nakagawa K, Izumi Y, Ogawa Y, Iwata T. Association of periodontal pocket area with type 2 diabetes and obesity: a cross-sectional study. BMJ Open Diabetes Res Care 2021; 9. 2) Simpson TC, Weldon JC, Worthington HV, Needleman I, Wild SH, Moles DR, Stevenson B, Furness S, Iheozor-Ejiofor Z. Treatment of periodontal disease for glycaemic control in people with diabetes mellitus. Cochrane Database Syst Rev 2015: CD004714. 17) Mizutani K, Aoki A, Coluzzi D, Yukna R, Wang CY, Pavlic V, Izumi Y. Lasers in minimally invasive periodontal and peri-implant therapy. Periodontol 2000 2016; 71: 185-212. 5) King GL. The role of inflammatory cytokines in diabetes and its complications. J Periodontol 2008; 79: 1527-1534. 21) Mikami R, Mizutani K, Matsuyama Y, Matsuura T, Kido D, Takeda K, Takemura S, Nakagawa K, Mukaiyama Y, Suda T, Yasuda T, Ohta S, Takaya N, Fujiwara T, Izumi Y, Iwata T. Association between periodontal inflammation and serum lipid profile in a healthy population: A cross-sectional study. J Periodontal Res 2021. (in press 1) Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, Herrera D, Jepsen S, Lione L, Madianos P, Mathur M, Montanya E, Shapira L, Tonetti M, Vegh D. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol 2018; 45: 138-149. 10) Saito N, Mikami R, Mizutani K, Takeda K, Kominato H, Kido D, Ikeda Y, Buranasin P, Nakagawa K, Takemura S, Ueno T, Hosaka K, Hanawa T, Shinomura T, Iwata T. Impaired dental implant osseointegration in rat with streptozotocin-induced diabetes. J Periodontal Res 2022. (in press |
| References_xml | – reference: 17) Mizutani K, Aoki A, Coluzzi D, Yukna R, Wang CY, Pavlic V, Izumi Y. Lasers in minimally invasive periodontal and peri-implant therapy. Periodontol 2000 2016; 71: 185-212. – reference: 2) Simpson TC, Weldon JC, Worthington HV, Needleman I, Wild SH, Moles DR, Stevenson B, Furness S, Iheozor-Ejiofor Z. Treatment of periodontal disease for glycaemic control in people with diabetes mellitus. Cochrane Database Syst Rev 2015: CD004714. – reference: 19) Mizutani K, Mikami R, Gohda T, Gotoh H, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Sasaki Y, Iwata T. Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study. Sci Rep 2020; 10: 21872. – reference: 7) Buranasin P, Mizutani K, Iwasaki K, Pawaputanon Na Mahasarakham C, Kido D, Takeda K, Izumi Y. High glucose-induced oxidative stress impairs proliferation and migration of human gingival fibroblasts. PLoS One 2018; 13: e0201855. – reference: 11) Mizutani K, Buranasin P, Mikami R, Takeda K, Kido D, Watanabe K, Takemura S, Nakagawa K, Kominato H, Saito N, Hattori A, Iwata T. Effects of antioxidant in adjunct with periodontal therapy in patients with type 2 diabetes: A systematic review and meta-analysis. Antioxidants (Basel) 2021; 10. – reference: 18) Mikami R, Mizutani K, Gohda T, Gotoh H, Matsuyama Y, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Fujiwara T, Iwata T. Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study. Clin Exp Nephrol 2021; 25: 58-65. – reference: 15) Mizutani K, Shioyama H, Matsuura T, Mikami R, Takeda K, Izumi Y, Aoki A, Iwata T. Periodontal regenerative therapy in patients with type 2 diabetes using minimally invasive surgical technique with enamel matrix derivative under 3-year observation: A prospective cohort study. J Periodontol 2021; 92: 1262-1273. – reference: 1) Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, Herrera D, Jepsen S, Lione L, Madianos P, Mathur M, Montanya E, Shapira L, Tonetti M, Vegh D. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol 2018; 45: 138-149. – reference: 10) Saito N, Mikami R, Mizutani K, Takeda K, Kominato H, Kido D, Ikeda Y, Buranasin P, Nakagawa K, Takemura S, Ueno T, Hosaka K, Hanawa T, Shinomura T, Iwata T. Impaired dental implant osseointegration in rat with streptozotocin-induced diabetes. J Periodontal Res 2022. (in press) – reference: 16) 水谷幸嗣, 三上理沙子, 松浦孝典, 和泉雄一, 岩田隆紀, 青木 章. 低侵襲の歯周外科治療にEr : YAGレーザーを応用した症例の長期経過. 日歯保存誌 2020 ; 63 : 96-104. – reference: 8) Kido D, Mizutani K, Takeda K, Mikami R, Matsuura T, Iwasaki K, Izumi Y. Impact of diabetes on gingival wound healing via oxidative stress. PLoS One 2017; 12: e0189601. – reference: 12) Kao RT, Nares S, Reynolds MA. Periodontal regeneration―intrabony defects: a systematic review from the AAP Regeneration Workshop. J Periodontol 2015; 86: S77-104. – reference: 5) King GL. The role of inflammatory cytokines in diabetes and its complications. J Periodontol 2008; 79: 1527-1534. – reference: 20) Takeda K, Mizutani K, Minami I, Kido D, Mikami R, Konuma K, Saito N, Kominato H, Takemura S, Nakagawa K, Izumi Y, Ogawa Y, Iwata T. Association of periodontal pocket area with type 2 diabetes and obesity: a cross-sectional study. BMJ Open Diabetes Res Care 2021; 9. – reference: 4) Rask-Madsen C, Kahn CR. Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol 2012; 32: 2052-2059. – reference: 21) Mikami R, Mizutani K, Matsuyama Y, Matsuura T, Kido D, Takeda K, Takemura S, Nakagawa K, Mukaiyama Y, Suda T, Yasuda T, Ohta S, Takaya N, Fujiwara T, Izumi Y, Iwata T. Association between periodontal inflammation and serum lipid profile in a healthy population: A cross-sectional study. J Periodontal Res 2021. (in press) – reference: 3) Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol 2011; 7: 738-748. – reference: 6) Mizutani K, Park K, Mima A, Katagiri S, King GL. Obesity-associated gingival vascular inflammation and insulin resistance. J Dent Res 2014; 93: 596-601. – reference: 13) Takeda K, Mizutani K, Matsuura T, Kido D, Mikami R, Noda M, Buranasin P, Sasaki Y, Izumi Y. Periodontal regenerative effect of enamel matrix derivative in diabetes. PLoS One 2018; 13: e0207201. – reference: 9) Kominato H, Takeda K, Mizutani K, Mikami R, Kido D, Buranasin P, Saito N, Takemura S, Nakagawa K, Nagasawa T, Iwata T. Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin-resistant prediabetes mice. J Periodontol 2021. (in press) – reference: 14) Takeda K, Mizutani K, Matsuura T, Kido D, Mikami R, Buranasin P, Saito N, Kominato H, Takemura S, Nakagawa K, Iwata T. Antioxidant effect of enamel matrix derivative for early phase of periodontal tissue regeneration in diabetes. J Periodontol 2021. (in press) |
| SSID | ssj0003236739 ssib001544041 ssib046627986 ssib002822014 ssib023160748 |
| Score | 2.2976413 |
| Snippet | 「はじめに」 歯周病は全身状態や内科疾患と密接な関連を有していることが明らかにされてきており, ペリオドンタルメディシンという概念の下で研究が進められている. 特に糖... |
| SourceID | medicalonline jstage |
| SourceType | Publisher |
| StartPage | 25 |
| SubjectTerms | 慢性腎臓病 歯周病 糖尿病 酸化ストレス |
| Subtitle | そのメカニズム解析と歯周治療への応用の展望 |
| Title | 糖尿病・慢性腎臓病と歯周病の関連 |
| URI | https://www.jstage.jst.go.jp/article/shikahozon/65/1/65_25/_article/-char/ja http://mol.medicalonline.jp/en/journal/download?GoodsID=do1conde/2022/006501/004&name=0025-0029j |
| Volume | 65 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本歯科保存学雑誌, 2022/02/28, Vol.65(1), pp.25-29 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Colorado Digital library customDbUrl: eissn: 2188-0808 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0003236739 issn: 0387-2343 databaseCode: KQ8 dateStart: 20140101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1Na9RANNR6EUQUFesXPTgnyZpkPjIDHpxssxRFQWihtzBJZqkr7opuLz1VZPEmiFDv9WAvfoBHD_4Y6bb9F743SbvZ6sFaWGZn37x5b968Sea9ZOc9z7tV5KwoS0l9G0XWZyaSfh4J5augzMsuWBTG5QZ8-EgsLrP7K3xl5lSv8a-ltWHeKtb_eq7kf7QKMNArnpI9hmYPiQIA6qBfKEHDUP6Tjkkak4QSJUjKSRKQpIMQFRPJSUqJpCRJSCrwp45cJSA6JqlEiExdBfDpdK-QaInIeoHoDlJWFeQIDnRXyBopK0eZNi1dpAD4mrtKm-h2g2aMwwCyKcMxqwXkAk1K1hUtHPHE4UiiNZGHT3ORDMrKsAUrMS4TNwOKJI4C8qXN5xngCk_Oh-MKxCFIhT2QYUqUdgxhCKkjACzcpEpgrhxH5uYSIDAoJxNOPHcSaPjcPrG80NSGcTTuzBiQOKJVfKmWdTAwlTDUdyCbW0uVBmPqEqr3Cd6wOKpHPn_uZWA34LJdffLUrA7WYekK3jroOBUivF6A2QQ1EzwLsYh4dtCKx_iyHvgSpyPYATHNyYPHzTemGCly6kxz1HjDDm6ACOKJ68wwcYCqQw-i1UMxFKBL3Hc4O_WfCFCOO0elAIOvB-4PxrU4-6x6JVmFhmlYd0vnvXO1WzavKyEueDM9c9ELdr9v7nz7ufth9Ov1j_Foa7zxaW_0du_Ne4S82h5__rrzbtvVv-xvbu1vfLzkLXfSpfaiX2cY8XtRwCOfUlqanJtuwEpW2pCGBZUlF7YAPz4wzIqukLaIA55b2Pq4Ml3FbMkY5wCEzfKyN9sf9O0Vb96YAtyVIrRWYkYGioazEYCtTJHngs55dyuBs-dVGJnsWFqb8-5NTVNW34ZeZuUgLAb90mZ4MWXO5Qrhi2XozmChwAcBxyy6erIRXPPOTC7X697s8MWavQEG-TC_6VbSbxpUt0k |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%B3%96%E5%B0%BF%E7%97%85%E3%83%BB%E6%85%A2%E6%80%A7%E8%85%8E%E8%87%93%E7%97%85%E3%81%A8%E6%AD%AF%E5%91%A8%E7%97%85%E3%81%AE%E9%96%A2%E9%80%A3&rft.jtitle=%E6%97%A5%E6%9C%AC%E6%AD%AF%E7%A7%91%E4%BF%9D%E5%AD%98%E5%AD%A6%E9%9B%91%E8%AA%8C&rft.au=%E6%B0%B4%E8%B0%B7%2C+%E5%B9%B8%E5%97%A3&rft.date=2022-02-28&rft.pub=%E7%89%B9%E5%AE%9A%E9%9D%9E%E5%96%B6%E5%88%A9%E6%B4%BB%E5%8B%95%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E6%AD%AF%E7%A7%91%E4%BF%9D%E5%AD%98%E5%AD%A6%E4%BC%9A&rft.issn=0387-2343&rft.eissn=2188-0808&rft.volume=65&rft.issue=1&rft.spage=25&rft.epage=29&rft_id=info:doi/10.11471%2Fshikahozon.65.25&rft.externalDocID=article_shikahozon_65_1_65_25_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0387-2343&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0387-2343&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0387-2343&client=summon |