LABORATORY AND CLINICAL EVALUATION OF TICARCILLIN IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

• Published in: CHEMOTHERAPY Vol. 25; no. 9; pp. 2911 - 2923
• Main Authors: FUJIYAMA, TAKEHISA, CHO, NANKUN, UEHARA, KAZUHIRO, NAKAYAMA, TETSUYA, MATSUZAKI, HIROSHI, KUNII, KATSUAKI, TAKEDA, JUZO
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1977
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.25.9_2911

The clinical studies on ticarcillin, a new derivative of semisynthetic penicillin, were made in the field of obstetrics and gynecology and the following results were obtained. The absorption of the drug was rapid and dose response recognized. The average peak level after intravenous injection of 1, 2, 3 g in 10 volunteers reached 74. 5, 184. 1, 288.8 μg/ml at fifteen minutes and halflife was 42-46 minutes. Urinary excretion was also rapid and excretion rate was 80% within 6 hours. The serum level after intramuscular injection of 1 g was compared with that of carbenicillin and peak level was 30.5 μg/ml, 29.0 μg/ml respectively, one hour after administration. The half-life was 2.10 and 2.04 hours. The transference of the drug into umbilical cord blood and amniotic fluid was good but very few in mother's milk. Ticarcillin was administered at daily dose of 1-6g intravenously to 15 patients (6 with intra pelvic infections, and 9 with urinary tract infections). Clinical response was excellent in 1 case, good in 12 cases and failed in 2 cases, effective rate being about 86. 7%. No noteworthy side effect was noted with ticarcillin.