各種腎疾患における尿中transforming growth factor-betaの測定
全身性エリテマトーデス(以下SLE) 10名,巣状糸球体硬化症(以下FGS) 8名, IgA腎症(以下IgAN) 9名,および膜性腎症(以下MN) 6名に対して,ヒトTGF-beta1+2+3に対するモノクローナル抗体を用いたELISA法にて,尿中TGF-betaの測定を行った.健常人の尿中TGF-betaが46.9±43.9ng/mgCrであるのに対して, SLE患者では96.4±58.2ng/mgCr, FGS患者では555.5±458.4ng/mgCr, IgAN患者では54.1±37.4ng/mgCr, MN患者では24.8±13.3ng/mgCrであった. FGS患者の尿中TGF-b...
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| Published in | 日本臨床免疫学会会誌 Vol. 17; no. 1; pp. 45 - 51 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本臨床免疫学会
1994
|
| Online Access | Get full text |
| ISSN | 0911-4300 1349-7413 |
| DOI | 10.2177/jsci.17.45 |
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| Abstract | 全身性エリテマトーデス(以下SLE) 10名,巣状糸球体硬化症(以下FGS) 8名, IgA腎症(以下IgAN) 9名,および膜性腎症(以下MN) 6名に対して,ヒトTGF-beta1+2+3に対するモノクローナル抗体を用いたELISA法にて,尿中TGF-betaの測定を行った.健常人の尿中TGF-betaが46.9±43.9ng/mgCrであるのに対して, SLE患者では96.4±58.2ng/mgCr, FGS患者では555.5±458.4ng/mgCr, IgAN患者では54.1±37.4ng/mgCr, MN患者では24.8±13.3ng/mgCrであった. FGS患者の尿中TGF-betaは,健常人と比較して有意に(p<0.05)高値であった.またSLE患者では健常人に比べて高値である傾向を示し,逆にMN患者では低値を示す傾向があった.一方, IgAN患者は健常人と差がみられなかった.このことからTGF-betaがヒトの腎炎においても,糸球体内の細胞増殖に対しては抑制的に働き,糸球体内のECM代謝に対しては蓄積を促進するように働いている可能性が示唆された. |
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| AbstractList | 全身性エリテマトーデス(以下SLE) 10名,巣状糸球体硬化症(以下FGS) 8名, IgA腎症(以下IgAN) 9名,および膜性腎症(以下MN) 6名に対して,ヒトTGF-beta1+2+3に対するモノクローナル抗体を用いたELISA法にて,尿中TGF-betaの測定を行った.健常人の尿中TGF-betaが46.9±43.9ng/mgCrであるのに対して, SLE患者では96.4±58.2ng/mgCr, FGS患者では555.5±458.4ng/mgCr, IgAN患者では54.1±37.4ng/mgCr, MN患者では24.8±13.3ng/mgCrであった. FGS患者の尿中TGF-betaは,健常人と比較して有意に(p<0.05)高値であった.またSLE患者では健常人に比べて高値である傾向を示し,逆にMN患者では低値を示す傾向があった.一方, IgAN患者は健常人と差がみられなかった.このことからTGF-betaがヒトの腎炎においても,糸球体内の細胞増殖に対しては抑制的に働き,糸球体内のECM代謝に対しては蓄積を促進するように働いている可能性が示唆された. |
| Author | 矢野, 新太郎 三橋, 秀基 小野, 久米夫 成清, 卓二 金井, 秀夫 |
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| References | 11) Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U. I., Liotta, L. A., Falanga, V., Kehrl, J. H., Fanci, A. S.: Transforming growth factor-beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. USA, 83: 4167-4171, 1986. 7) Sporn, M. B., Robert, A. B.: Peptide growth factors and inflammation, tissue repair and cancer. J. Clin. Invest., 78: 329-332, 1986. 10) Ruoslahti, E., Pierschbacher, M. O.: New perspectives in cell adhesion. RGD and integrin. Science, 238: 491-497, 1987. 17) Martyre, M. C., Magdelenat, H., Bryckaert, M. C., Bidron, C. L., Calvo, F.: Increased intraplatelet levels of platelet-derived growth factor and transforming growth factor-β in patients with myelofibrosis with myeloid metaplasia. Br. J. Haematology. 77: 80-86, 1991. 8) Lafyatis, R., Remmers, E. F., Roberts, A. B., Yocum, D. E., Sporn, M. B., Wilder, R. L.: Anchorage-independent growth of synoviocytes from arthritic and normal joints: Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J. Clin. Invest., 83: 1267-1276, 1989. 1) Roberts, A. B., Anzano, M. A., Wakefield, L. M., Roche, N. S., Stern, D. F., Sporn, M. B.: Type beta transforming growth factor, a bifunctional regulator of cellular growth. Proc. Natl. Acad. Sci. USA, 82: 119-123, 1985. 3) Miyazono, K., Hellmann, U., Wernstedt, C. et al.: Latent high molecular weight complex of transforming growth factor β1. J. Biol. Chem., 263: 6407-6415, 1988. 13) Morales, T. I., Roberts, A. B.: Transforming growth factor-β regulates the metabolism of proteoglycans in bovine cartilage organ cultures. J. Biol. Chem., 263: 12828-12831, 1988. 19) Mackay, K., Kondaiah, P., Danielpour, D., Austin, III H. A., Brown, P.D.: Expression of transforming growth factor-β1 and β2 in rat glomeruli. Kidney Int., 38: 1095-1100, 1990. 22) Border, W., Ruoslahti, E.: Transforming growth factor -β1, induces extracellular matrix formation in glomerulonephritis. Cell Differentiation and Development, 32: 425-432, 1990. 15) Border, W. A. et al.: Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1. Nature, 346: 371-374, 1990. 16) Border, W. A., Ruoslahti, E.: Transforming growth factor-β in diseases: The dark side of tissue repair. J. Clin. Invest., 90: 1-7, 1992. 21) Assoian, R. K., Sporn, M. B.: Type β transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells. Journal of Cellular Biology, 102: 1217-1223, 1986. 18) Jones, C. L. et al.: Pathogenesis of interstitial fibrosis in chronic purine aminonucleoside nephrosis. Kidney Int., 40: 1020, 1991. 4) Okada, F., Yamaguchi, K., Ichihara, A. et al.: Purification and structural analysis of a latent form of transforming growth factor β from rat platelets. J. Biochem., 106: 304-310, 1989. 14) Okuda, S., Languino, R., Ruoslahti, E., Border, A.: Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis. J. Clin. Invest., 86: 453-462, 1990. 6) Sporn, M. B., Robert, A. B.: Autocrine growth factors and cancer. Nature, 313: 745-747, 1985. 12) Ignotz, R. A., Massague, J.: Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem., 261: 4337-4345, 1986. 2) Roberts, A. B., Flanders, K. C., Kondaiah, P., Thompson, N. L., Schilling, E. V., Wakefield, L., Rossi, P., Crombrugghe, B. D., Heine, U., Sporn, M. B.: Transforming growth factor-β: Biochemistry and roles in embryogenesis, tissue repair, and remodeling and carcinogenesis. Recent Prog. Horm. Res., 44: 157-197, 1988. 5) Lyons, R. M., Keski-Oja, J., Moses, H. L. et al.: Proteolytic activation of latent transforming growth factor-β from fibroblast-conditioned medium. J. Cell Biol., 106: 1659-1665, 1988. 9) de Martin, R., Haendler, B., Hofer-Warbinek, R., Gangitsch, H., Wrann, M., Schlusener, H., Seifert, J. M., Bodmer, S., Fontana, A., Hofer, E.: Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-β gene family. EMBO J., 6: 3673-3677, 1987. 20) Pabst, R., Sterzel, R. B.: Cell renewal of glomerular cell types in normal rats. Kidney Int., 24: 626-631, 1983. |
| References_xml | – reference: 11) Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U. I., Liotta, L. A., Falanga, V., Kehrl, J. H., Fanci, A. S.: Transforming growth factor-beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. USA, 83: 4167-4171, 1986. – reference: 8) Lafyatis, R., Remmers, E. F., Roberts, A. B., Yocum, D. E., Sporn, M. B., Wilder, R. L.: Anchorage-independent growth of synoviocytes from arthritic and normal joints: Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J. Clin. Invest., 83: 1267-1276, 1989. – reference: 5) Lyons, R. M., Keski-Oja, J., Moses, H. L. et al.: Proteolytic activation of latent transforming growth factor-β from fibroblast-conditioned medium. J. Cell Biol., 106: 1659-1665, 1988. – reference: 10) Ruoslahti, E., Pierschbacher, M. O.: New perspectives in cell adhesion. RGD and integrin. Science, 238: 491-497, 1987. – reference: 13) Morales, T. I., Roberts, A. B.: Transforming growth factor-β regulates the metabolism of proteoglycans in bovine cartilage organ cultures. J. Biol. Chem., 263: 12828-12831, 1988. – reference: 22) Border, W., Ruoslahti, E.: Transforming growth factor -β1, induces extracellular matrix formation in glomerulonephritis. Cell Differentiation and Development, 32: 425-432, 1990. – reference: 19) Mackay, K., Kondaiah, P., Danielpour, D., Austin, III H. A., Brown, P.D.: Expression of transforming growth factor-β1 and β2 in rat glomeruli. Kidney Int., 38: 1095-1100, 1990. – reference: 9) de Martin, R., Haendler, B., Hofer-Warbinek, R., Gangitsch, H., Wrann, M., Schlusener, H., Seifert, J. M., Bodmer, S., Fontana, A., Hofer, E.: Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-β gene family. EMBO J., 6: 3673-3677, 1987. – reference: 15) Border, W. A. et al.: Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1. Nature, 346: 371-374, 1990. – reference: 16) Border, W. A., Ruoslahti, E.: Transforming growth factor-β in diseases: The dark side of tissue repair. J. Clin. Invest., 90: 1-7, 1992. – reference: 20) Pabst, R., Sterzel, R. B.: Cell renewal of glomerular cell types in normal rats. Kidney Int., 24: 626-631, 1983. – reference: 1) Roberts, A. B., Anzano, M. A., Wakefield, L. M., Roche, N. S., Stern, D. F., Sporn, M. B.: Type beta transforming growth factor, a bifunctional regulator of cellular growth. Proc. Natl. Acad. Sci. USA, 82: 119-123, 1985. – reference: 2) Roberts, A. B., Flanders, K. C., Kondaiah, P., Thompson, N. L., Schilling, E. V., Wakefield, L., Rossi, P., Crombrugghe, B. D., Heine, U., Sporn, M. B.: Transforming growth factor-β: Biochemistry and roles in embryogenesis, tissue repair, and remodeling and carcinogenesis. Recent Prog. Horm. Res., 44: 157-197, 1988. – reference: 3) Miyazono, K., Hellmann, U., Wernstedt, C. et al.: Latent high molecular weight complex of transforming growth factor β1. J. Biol. Chem., 263: 6407-6415, 1988. – reference: 6) Sporn, M. B., Robert, A. B.: Autocrine growth factors and cancer. Nature, 313: 745-747, 1985. – reference: 14) Okuda, S., Languino, R., Ruoslahti, E., Border, A.: Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis. J. Clin. Invest., 86: 453-462, 1990. – reference: 7) Sporn, M. B., Robert, A. B.: Peptide growth factors and inflammation, tissue repair and cancer. J. Clin. Invest., 78: 329-332, 1986. – reference: 4) Okada, F., Yamaguchi, K., Ichihara, A. et al.: Purification and structural analysis of a latent form of transforming growth factor β from rat platelets. J. Biochem., 106: 304-310, 1989. – reference: 12) Ignotz, R. A., Massague, J.: Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem., 261: 4337-4345, 1986. – reference: 18) Jones, C. L. et al.: Pathogenesis of interstitial fibrosis in chronic purine aminonucleoside nephrosis. Kidney Int., 40: 1020, 1991. – reference: 21) Assoian, R. K., Sporn, M. B.: Type β transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells. Journal of Cellular Biology, 102: 1217-1223, 1986. – reference: 17) Martyre, M. C., Magdelenat, H., Bryckaert, M. C., Bidron, C. L., Calvo, F.: Increased intraplatelet levels of platelet-derived growth factor and transforming growth factor-β in patients with myelofibrosis with myeloid metaplasia. Br. J. Haematology. 77: 80-86, 1991. |
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| Title | 各種腎疾患における尿中transforming growth factor-betaの測定 |
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