Studies on the Fate of Poisonous Metals in Experimental Animal (VIII) Species Difference on Biological Half Life of Cadmium

About 30-60μCi/0.15mg Cd/kg of cadmium chloride solution containing 115mCd was injected intraperitoneally to mice, rats, guinea pigs, rabbits and quails, and thereafter the whole body retention of Cd was measured continuously for 60-92 days in order to find the biological half lives of the metal in...

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Published inFood Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) Vol. 19; no. 2; pp. 228 - 232_1
Main Authors NAKAURA, Shinsuke, HASEGAWA, Akira, URAKUBO, Goro, ONODA, Kin-ichi, OMORI, Yoshihito, IKEBUCHI, Hideharu
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society for Food Hygiene and Safety 1978
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ISSN0015-6426
1882-1006
DOI10.3358/shokueishi.19.228

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Summary:About 30-60μCi/0.15mg Cd/kg of cadmium chloride solution containing 115mCd was injected intraperitoneally to mice, rats, guinea pigs, rabbits and quails, and thereafter the whole body retention of Cd was measured continuously for 60-92 days in order to find the biological half lives of the metal in these animals. The whole body retention was determined by whole body counting of radioactivity in mice, rats, guinea pigs and quails, but in the case of rabbit it was determined by counting rates of excreta. The biological half lives thus obtained in mouse, rat, guinea pig, rabbit and quail were 220, 150 and 181, 334, 299 and 367 days, respectively. Namely, an apparent species difference was observed even under the same conditions such as sex of animal, dose of metal per kg and dosing route.
ISSN:0015-6426
1882-1006
DOI:10.3358/shokueishi.19.228