胸部FDG PET画像上での肺結節検出能に関する実験的息止め撮像の検討
最近,呼吸運動のPET画像への影響を抑制するために,息止め胸部FDG PET検査が行われる機会が増加している。しかし,患者にとって30秒間以上の息止め撮像は容易ではない。撮像時間の短縮が可能かどうかを検討するため,胸部PET画像における息止めの効果をファントムを使って実験した。180秒間の呼吸運動に摸した連続運動状態で撮像された画像を,60,90,120,150,180秒間(15秒間×4,6,8,10,12回)の各収集時間で撮像された静止画像と比較した。撮像時間の短縮により,バックグランド領域のカウントの統計変動が増悪したが,180秒間の連続運動下で撮像された画像と比較して,60,90秒間の撮...
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| Published in | RADIOISOTOPES Vol. 59; no. 10; pp. 587 - 598 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
公益社団法人 日本アイソトープ協会
2010
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| Online Access | Get full text |
| ISSN | 0033-8303 1884-4111 |
| DOI | 10.3769/radioisotopes.59.587 |
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| Abstract | 最近,呼吸運動のPET画像への影響を抑制するために,息止め胸部FDG PET検査が行われる機会が増加している。しかし,患者にとって30秒間以上の息止め撮像は容易ではない。撮像時間の短縮が可能かどうかを検討するため,胸部PET画像における息止めの効果をファントムを使って実験した。180秒間の呼吸運動に摸した連続運動状態で撮像された画像を,60,90,120,150,180秒間(15秒間×4,6,8,10,12回)の各収集時間で撮像された静止画像と比較した。撮像時間の短縮により,バックグランド領域のカウントの統計変動が増悪したが,180秒間の連続運動下で撮像された画像と比較して,60,90秒間の撮像時間の静止画像は直径10mmの小さな結節を可視化できた。著者らの研究から,息止めにより,より短い撮像時間で胸部FDG PET画像上のより小さな結節が検出できることが示された。 |
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| AbstractList | 最近,呼吸運動のPET画像への影響を抑制するために,息止め胸部FDG PET検査が行われる機会が増加している。しかし,患者にとって30秒間以上の息止め撮像は容易ではない。撮像時間の短縮が可能かどうかを検討するため,胸部PET画像における息止めの効果をファントムを使って実験した。180秒間の呼吸運動に摸した連続運動状態で撮像された画像を,60,90,120,150,180秒間(15秒間×4,6,8,10,12回)の各収集時間で撮像された静止画像と比較した。撮像時間の短縮により,バックグランド領域のカウントの統計変動が増悪したが,180秒間の連続運動下で撮像された画像と比較して,60,90秒間の撮像時間の静止画像は直径10mmの小さな結節を可視化できた。著者らの研究から,息止めにより,より短い撮像時間で胸部FDG PET画像上のより小さな結節が検出できることが示された。 |
| Author | 佐々木, 達也 森山, 紀之 津田, 啓介 福士, 政広 根本, 幸一 藤井, 博史 岩渕, 勇人 |
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| References_xml | – reference: 3)Meirelles, G. S. P., Erdi, Y. E., Nehmeh, S. A., Squire, O. D., Larson, S. M., Humm, J. L. and Schö-der, H., Deep-inspiration breath-hold PET/CT: clinical findings with a new technique for detection and characterization of thoracic lesions, J. Nucl. Med., 48, 712-719(2007) – reference: 10)Defrise, M., Kinahan, P. E., Townsend, D. W., Michel, C., Sibomana, M. and Newport, D. F., Exact and approximate rebinning algorithms for 3-D PET data, IEEE. Trans. Med. Imaging., 16, 145-158(1977) – reference: 20)Kagna, O., Solomonov, A., Keidar, Z., Bar-Shalom, R., Fruchter, O., Yigla, M., Israel, O. and Guralnik, L., The value of FDG-PET/CT in assessing pulmonary nodules in patients at high risk of lung cancer, Eur. J. Nucl. Med. Mol. Imaging., 36, 997-1004(2009) – reference: 19)Ganong, F. W., Review of Medical Physiology, 19th edition, pp.617-623, Appleton & Lange, Stamford(1999) – reference: 14)Inoue, K., Sato, T., Kitamura, H., Ito, M., Tsunoda, Y., Hirayama, A., Kurosawa, H., Tanaka, T., Fukushi, M., Moriyama, N. and Fujii, H., Improvement of the diagnostic accuracy of lymph node metastases of colorectal cancer in 18F-FDG PET/CT by optimizing the iteration number for the image reconstruction, Ann. Nucl. Med., 22, 465-473(2008) – reference: 2)Nehmeh, S. A., Erdi, Y. E., Meirelles, G. S. P., Squire, O., Larson, S. M., Humm, J. L. and Schö-der, H., Deep-inspiration breath-hold PET/CT of the thorax, J. Nucl. Med., 48, 22-26(2007) – reference: 15)Nagayoshi, M., Murase, K., Fujino, K., Uenishi, Y., Kawamata, M., Nakamura, Y., Kitamura, K., Higuchi, I., Oku, N. and Hatazawa, J., Usefulness of noise adaptive non-linear gaussian filter in FDG-PET study, Ann. Nucl. Med., 19, 469-477(2005) – reference: 17)Willinek, W. A., Born, M., Simon, B., Tschampa, H. J., Krautmacher, C., Gieseke, J., Urbach, H., Textor, H. J. and Schild, H. H., Time-of-flight MR angiography:comparison of 3.0-T imaging and 1.5-T imaging-initial experience, Radiology, 229, 913-920(2003) – reference: 5)Yamaguchi, T., Ueda, O., Hara, H., Sakai, H., Kida, T., Suzuki, K., Adachi, S. and Ishii, K., Usefulness of a breath-holding acquisition method in PET/CT for pulmonary lesions, Ann. Nucl. Med., 23, 65-71(2009) – reference: 1)Beyer, T., Townsend, D. W., Brun, T., Kinahan, P. E., Charron, M., Roddy, R., Jerin, J., Young, J., Byars, L. and Nutt, R., A combined PET/CT scanner for clinical oncology, J. Nucl. Med., 41, 1369-1379(2000) – reference: 12)Burger, C., Goerres, G., Schoenes, S., Buck, A., Lonn, A. H. R. and von Schulthess, G. K., PET attenuation coefficients from CT image: experimental evaluation of the transformation of CT into PET 511-keV attenuation coefficients, Eur. J. Nucl. Med., 29, 922-927(2002) – reference: 8)Performance measurements of positron emission tomographs, NEMA Standards Publication NU 2-2001, National Electrical Manufacturers Association, Rosslyn(2001) – reference: 11)Hudson, H. M. and Larkin, R. S., Accelerated image reconstruction using ordered subsets of projection data, IEEE. Trans. Med. Imaging., 13, 601-609(1994) – reference: 13)Ollinger, J. M., Model-based scatter correction for fully 3D PET, Phys. Med. Biol., 41, 153-176(1996) – reference: 16)Strobel, K., Rüdy, M., Treyer, V., Veit-Haibach, P., Burger, C. and Hany, T. F., Objective and subjective comparison of standard 2-D and fully 3-D reconstructed data on a PET/CT system, Nucl. Med. Commun., 28, 555-559(2007) – reference: 6)Nagamachi, S., Wakamatsu, H., Kiyohara, S., Fujita, S., Futami, S., Arita, H., Tamura, S. and Kawai, K., The reproducibility of deep-inspiration breath-hold 18F-FDG PET/CT technique in diagnosing various cancers affected by respiratory motion, Ann. Nucl. Med., 24, 171-178(2010) – reference: 7)Daisaki, H., Shinohara, H., Terauchi, T., Murano, T., Shimada, N., Moriyama, N. and Tateishi, U., Multi-bed-position acquisition technique for deep inspiration breath-hold PET/CT:a preliminary result for pulmonary lesions, Ann. Nucl. Med., 24, 179-188(2010) – reference: 18)R Development Core Team. R:A language and environment for statistical computing. Vienna:R Foundation for Statistical Computing(2008) – reference: 4)Kawano, T., Ohtake, E. and Inoue, T., Deep-inspiration breath-hold PET/CT of lung cancer: maximum standardized uptake value analysis of 108 patients, J. Nucl. Med., 49, 1223-1231(2008) – reference: 9)Mawlawi, O., Podoloff, D. A., Kohlmyer, S., Williams, J. J., Stearns, C. W., Culp, R. F. and Macapinlac, H., Performance characteristics of a newly developed PET/CT scanner using NEMA standards in 2D and 3D modes, J. Nucl. Med., 45, 1734-1742(2004) |
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| Title | 胸部FDG PET画像上での肺結節検出能に関する実験的息止め撮像の検討 |
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