子宮頸部胞巣状軟部肉腫（alveolar soft part sarcoma: ASPS）の1症例
胞巣状軟部肉腫（alveolar soft part sarcoma, 以下ASPS）は稀な軟部肉腫疾患で，女性性器原発は大変稀である．今回，われわれは子宮頸部原発の胞巣状軟部肉腫を経験したので報告する．症例：50歳，2経妊1経産．子宮頸管ポリープ間質に異型細胞を認め，当院へ紹介受診．画像所見から悪性腫瘍が疑われる頸部腫瘤3cmを認め，頸管内膜組織診からASPSが疑われたため，準広汎子宮全摘術および両側付属器摘出術を施行．楕円形核と淡明な胞体を有する異型細胞の胞巣状増殖，TFE3（Transcription Factor E3）免疫染色陽性からASPSと最終診断された．術後13か月の時点で再発...
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| Published in | 昭和学士会雑誌 Vol. 77; no. 4; pp. 467 - 474 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
昭和大学学士会
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2187-719X 2188-529X |
| DOI | 10.14930/jshowaunivsoc.77.467 |
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| Abstract | 胞巣状軟部肉腫（alveolar soft part sarcoma, 以下ASPS）は稀な軟部肉腫疾患で，女性性器原発は大変稀である．今回，われわれは子宮頸部原発の胞巣状軟部肉腫を経験したので報告する．症例：50歳，2経妊1経産．子宮頸管ポリープ間質に異型細胞を認め，当院へ紹介受診．画像所見から悪性腫瘍が疑われる頸部腫瘤3cmを認め，頸管内膜組織診からASPSが疑われたため，準広汎子宮全摘術および両側付属器摘出術を施行．楕円形核と淡明な胞体を有する異型細胞の胞巣状増殖，TFE3（Transcription Factor E3）免疫染色陽性からASPSと最終診断された．術後13か月の時点で再発なく経過している． |
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| AbstractList | 胞巣状軟部肉腫（alveolar soft part sarcoma, 以下ASPS）は稀な軟部肉腫疾患で，女性性器原発は大変稀である．今回，われわれは子宮頸部原発の胞巣状軟部肉腫を経験したので報告する．症例：50歳，2経妊1経産．子宮頸管ポリープ間質に異型細胞を認め，当院へ紹介受診．画像所見から悪性腫瘍が疑われる頸部腫瘤3cmを認め，頸管内膜組織診からASPSが疑われたため，準広汎子宮全摘術および両側付属器摘出術を施行．楕円形核と淡明な胞体を有する異型細胞の胞巣状増殖，TFE3（Transcription Factor E3）免疫染色陽性からASPSと最終診断された．術後13か月の時点で再発なく経過している． |
| Author | 加藤, 明澄 市原, 三義 秋野, 亮介 土肥, 聡 八木, 由里子 瀬尾, 晃平 市塚, 清健 中里, 佐保子 奥山, 亜由美 松浦, 玲 折坂, 勝 長塚, 正晃 河野, 春香 |
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| References | 5）Heimann P, Devalck C, Debusscher C, et al. Alveolar soft-part sarcoma: further evidence by FISH for the involvement of chromosome band 17q25. Genes Chromosomes Cancer. 1998;23:194-197. 7）Lillehei KO, Kleinschmidt-DeMasters B, Mitchell DH, et al. Alveolar soft part sarcoma: an unusually long interval between presentation and brain metastasis. Hum Pathol. 1993;24:1030-1034. 2）Lieberman PH, Brennan MF, Kimmel M, et al. Alveolar soft-part sarcoma. A clinico-pathologic study of half a century. Cancer. 1989;63:1-13. 6）Schoolmeester JK, Carlson J, Keeney GL, et al. Alveolar soft part sarcoma of the female genital tract: a morphologic, immunohistochemical, and molecular cytogenetic study of 10 cases with emphasis on its distinction from morphologic mimics. Am J Surg Pathol. 2017;41:622-632. 3）Hasegawa K, Ichikawa R, Ishii R, et al. A case of primary alveolar soft part sarcoma of the uterine cervix and a review of the literature. Int J Clin Oncol. 2011;16:751-758. 4）Feng M, Jiang W, He Y, et al. Primary alveolar soft part sarcoma of the uterine cervix: a case report and literature review. Int J Clin Exp Pathol. 2014;7:8223-8226. 1）Christopherson WM, Foote FW Jr, Stewart FW. Alveolar soft-part sarcomas: structurally characteristic tumors of uncertain histogenesis. Cancer. 1952;5:100-111. |
| References_xml | – reference: 3）Hasegawa K, Ichikawa R, Ishii R, et al. A case of primary alveolar soft part sarcoma of the uterine cervix and a review of the literature. Int J Clin Oncol. 2011;16:751-758. – reference: 1）Christopherson WM, Foote FW Jr, Stewart FW. Alveolar soft-part sarcomas: structurally characteristic tumors of uncertain histogenesis. Cancer. 1952;5:100-111. – reference: 4）Feng M, Jiang W, He Y, et al. Primary alveolar soft part sarcoma of the uterine cervix: a case report and literature review. Int J Clin Exp Pathol. 2014;7:8223-8226. – reference: 7）Lillehei KO, Kleinschmidt-DeMasters B, Mitchell DH, et al. Alveolar soft part sarcoma: an unusually long interval between presentation and brain metastasis. Hum Pathol. 1993;24:1030-1034. – reference: 2）Lieberman PH, Brennan MF, Kimmel M, et al. Alveolar soft-part sarcoma. A clinico-pathologic study of half a century. Cancer. 1989;63:1-13. – reference: 5）Heimann P, Devalck C, Debusscher C, et al. Alveolar soft-part sarcoma: further evidence by FISH for the involvement of chromosome band 17q25. Genes Chromosomes Cancer. 1998;23:194-197. – reference: 6）Schoolmeester JK, Carlson J, Keeney GL, et al. Alveolar soft part sarcoma of the female genital tract: a morphologic, immunohistochemical, and molecular cytogenetic study of 10 cases with emphasis on its distinction from morphologic mimics. Am J Surg Pathol. 2017;41:622-632. |
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| Title | 子宮頸部胞巣状軟部肉腫（alveolar soft part sarcoma: ASPS）の1症例 |
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