A Case of Liver Metastasis 9 Years after Resection of Gastrointestinal Stromal Tumor of the Duodenum

• Published in: The Japanese Journal of Gastroenterological Surgery Vol. 44; no. 7; pp. 842 - 847
• Main Authors: Takahashi, Hidenori, Ohue, Masayuki, Yamada, Terumasa, Fukuda, Shuichi, Yamamoto, Masayuki, Yano, Masahiko, Miyashiro, Isao, Ishikawa, Osamu, Gotoh, Kunihito, Ohigashi, Hiroaki
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society of Gastroenterological Surgery 2011
• Subjects: duodenum; gastrointestinal stromal tumor; liver metastasis
• ISSN: 0386-9768; 1348-9372
• DOI: 10.5833/jjgs.44.842

A 65-year-old man underwent a partial duodenectomy for a 35 mm gastrointestinal stromal tumor (GIST) located in the third portion of the duodenum in August, 2000 and was followed up with no adjuvant therapy. A liver mass was detected by abdominal CT in June, 2009 and he was referred to our hospital for examination and treatment. Though disease-free survival was as long as 9 years, a biopsy of the liver mass strongly suggested liver metastasis from the GIST of the duodenum. The specimen was composed of spindle cells positive for c-kit immunohistologically, and GIST was diagnosed. Because the mass was solitary and the liver function was good, we judged that there was an indication for operation, and performed a right hepatectomy. In this case, asymptomatic liver metastasis was detected by the imaging diagnosis, so it is suggested that long-term follow-up including diagnostic imaging is needed for patients with GIST of the duodenum even 5 years or more after the operation.