Combined chemotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF), and radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN)

• Published in: Nippon Jibi Inkoka Gakkai Kaiho Vol. 108; no. 2; p. 157
• Main Authors: Katori, Hideaki, Tsukuda, Mamoru, Ishitoya, Junichi, Mikami, Yasukazu, Matsuda, Hideki, Tanigaki, Yuji, Horiuchi, Chouichi, Ikeda, Youichi, Kimura, Machiko, Taguchi, Takahide, Hirose, Shouji, Yoshida, Takashi, Takahashi, Masahiro, Sakuma, Yasunori, Yamamoto, Kaoru, Sato, Nao
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.02.2005
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carcinoma, Squamous Cell - therapy; Cisplatin - administration & dosage; Combined Modality Therapy; Docetaxel; Fluorouracil - administration & dosage; Head and Neck Neoplasms - therapy; Humans; Taxoids - administration & dosage
• ISSN: 0030-6622
• DOI: 10.3950/jibiinkoka.108.157

We evaluated the recommend dose and efficacy of chemotherapy (CTx) and concurrent chemoradiotherapy (ConcCRTx) with docetaxel (DOC), cisplatin (CDDP) and 5-FU (TPF) in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). Patients underwent 2 cycles of chemotherapy with TPF. In ConcCRTx, radiation was targeted to begin on Day 1. We compared the efficacy of ConcCRTx and induction chemotherapy followed by radiation (CTx followed by RTx) with TPF. In CTx followed by RTx, radiation was targeted to begin 21 days after the end of CTx. The recommend dose of CTx with TPF was DOC 60 (Day 1), CDDP 70 (Day 4) and 5 FU 750 (Day 1-5) mg/ m2/ day and overall response rate of CTx with TPF was 95%. The recommended dose of ConcCRTx was DOC 50 (Day 1), CDDP 60 (Day 4) and 5-FU 600 (Day 1-5) mg/ m2/ day. Overall response rate of ConcCRTx and CTx followed by RTx with TPF were both 100%, and CR rate of them were 87% and 84% (p > 0.05). One-year survival rate of them were 69% and 95% (p < 0.05). More patients had distant metastasis in CTx followed by RTx than in ConcCRTx. Toxicity, such as mucositis, leukocytopenia and neutropenia, was higher in ConcCRTx than in CTx followed by RTx.