塩化コバルトによる家兎の肝および心の脂質ならびに糖質代謝におよぼす影響について

体重1kg当り25mgの塩化コバルトを空腹状態のオス家兎に毎日1回3日間注射して肝, 心の脂質ならびに糖質代謝の中間生成物に及ぼす影響を観察した。 塩化コバルト注射によって血糖は顕著に上昇し, 心では空腹によって低下したブドウ糖は増加した。肝では塩化コバルトによる血糖上昇に伴ってブドウ糖は顕著に上昇し, 空腹によって減少したG-6-P, F-6-Pの含有量は増加した。 塩化コバルトによって血漿のトリグリセライド (TG) は空腹群に比べて約4倍増加したが心のTGは増加の傾向を示し, 肝のTGも正常摂食群に比べて増加したが空腹群に比べて有意差はなかった。塩化コバルト注射によって, 空腹状態で上昇...

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Published in日本衛生学雑誌 Vol. 28; no. 5; pp. 456 - 462
Main Authors 長谷川, 武志, 小池, 重夫, 大山, 佳代子, 森田, 博行
Format Journal Article
LanguageEnglish
Japanese
Published 一般社団法人日本衛生学会 1973
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ISSN0021-5082
1882-6482
DOI10.1265/jjh.28.456

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Abstract 体重1kg当り25mgの塩化コバルトを空腹状態のオス家兎に毎日1回3日間注射して肝, 心の脂質ならびに糖質代謝の中間生成物に及ぼす影響を観察した。 塩化コバルト注射によって血糖は顕著に上昇し, 心では空腹によって低下したブドウ糖は増加した。肝では塩化コバルトによる血糖上昇に伴ってブドウ糖は顕著に上昇し, 空腹によって減少したG-6-P, F-6-Pの含有量は増加した。 塩化コバルトによって血漿のトリグリセライド (TG) は空腹群に比べて約4倍増加したが心のTGは増加の傾向を示し, 肝のTGも正常摂食群に比べて増加したが空腹群に比べて有意差はなかった。塩化コバルト注射によって, 空腹状態で上昇した血漿FFAは減少したが正常摂食群に比べると増加していた。 上昇した血漿FFAは肝でエステル化されてTGの合成に消費されたが残りは Ketone 体合成に使われ, コバルト注射群と空腹群との血中のβ-Hydroxybutyrate 量の上昇は同じ程度であった。
AbstractList 体重1kg当り25mgの塩化コバルトを空腹状態のオス家兎に毎日1回3日間注射して肝, 心の脂質ならびに糖質代謝の中間生成物に及ぼす影響を観察した。 塩化コバルト注射によって血糖は顕著に上昇し, 心では空腹によって低下したブドウ糖は増加した。肝では塩化コバルトによる血糖上昇に伴ってブドウ糖は顕著に上昇し, 空腹によって減少したG-6-P, F-6-Pの含有量は増加した。 塩化コバルトによって血漿のトリグリセライド (TG) は空腹群に比べて約4倍増加したが心のTGは増加の傾向を示し, 肝のTGも正常摂食群に比べて増加したが空腹群に比べて有意差はなかった。塩化コバルト注射によって, 空腹状態で上昇した血漿FFAは減少したが正常摂食群に比べると増加していた。 上昇した血漿FFAは肝でエステル化されてTGの合成に消費されたが残りは Ketone 体合成に使われ, コバルト注射群と空腹群との血中のβ-Hydroxybutyrate 量の上昇は同じ程度であった。
Author 小池, 重夫
大山, 佳代子
森田, 博行
長谷川, 武志
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  fullname: 森田, 博行
  organization: 昭和大学医学部衛生学教室
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References 19) Cahill, G. F. Jr., Ashmore, J., Renold, A. E. and Hasting, A. B.: Blood glucose and liver, Am. J. Med., 26, 264-282 (1959
9) Eggstein, M. und Kuhlmann, E: Triglyceride und Glycerin, in Methoden der enzymatischen Analyse (Herausgeben von H. U. Bergmeyer) S. 1765, Verlag Chemie, Berlin (1970).
21) Start, C. and Newsholme, E. A.: The effects of starvation and alloxan-diabetes on the contents of citrate and other metabolic intermediates in rat liver, Biochem. J., 107, 411-415 (1968).
29) Robey, J. S., Veazey, P. M. and Crawford, J. D.: Cobalt-induced myxedema, Report of a case, New Engl. J. Med., 255, 955-957 (1956
20) Steiner, D. F. and Williams, R. H.: Some observations concerning hepatic glucose-6-phosphate content in normal and diabetic rats, J. Biol. Chem., 234, 1342-1346 (1959
1) Bonenfant, J-L., Miller, G. and Roy, P. E.: Quebec beer-drinkers' cardiomyopathy. Pathologic studies, Canad. Med. Assc. J. 97, 910-916 (1967).
30) Caplan, R. and Curtis, A.: Xanthoma of the skin, J. Am. Med. Assoc., 176, 859-863 (1961
31) Havel, R. J., Felts, J. M. and Van Duyne, C. M.: Formation and fate of endogenous triglycerides in blood plasma of rabbits, J. Lip. Res., 3, 297-308 (1962
15) Jedeikin, L. A.: Cardiac glycogen metabolism in vivo in fed and starved rats, Biochem. J., 99, 6p (1966).
35) Webb, M.: The biological action of cobalt and other metals, III. Chelation of cations by dihydroxylipoic acid, Biochim. Biophys. Acta, 65, 47-65 (1962
4) Seifter, S., Dayton, S., Novic, B. and Muntwyler, E.: The determination of glycogen with the anthrone reagent, Arch. Biochem. Biophys., 25, 191-200 (1951).
8) Folch, J., Lees, M. and Sloane, G. H.: A simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem., 226, 479-506 (1957).
10) Laurell, S. and Tibbling, G.: Colorimetric microdetermination of free fatty acids in plasma, Clin. Chim. Acta, 16, 57-62 (1967).
32) Masora, E. J.: Physiological chemistry of lipids in mammales, P. 218, Saunders Comp. Philadelphia (1968
36) Alexander, C. S.: Cobalt and the heart, Annals Int. Med., 70, 411-413 (1969
25) Lochner, J. V., Eisentraut, A. M. and Unger, R.H.: The effect of CoCl2 on glucagon levels in plasma and pancreas of the rat, Metabolism, 13, 868-874 (1964
26) Fodden, J. H. and Read, W. H.: The activity of extracted pancreatic hyperglycemic-glycogenolytic factor after cobaltous chloride and synthalin A, Endocrinology, 54, 303-310 (1944
7) Bücher, J. und Hohorst, H. J.: D-Fructose-1, 6-diphosphat, Dihydroxyaceton-phosphat und D-Glycerinaldehyd-3-phosphat, in Methoden der enzymatischen Analyse, (Herausgeben von H. U. Bergmeyer) S. 1282, Verlag Chemie, Berlin (1970
12) Alexander, C. S.: Cobalt cardiomyopathy, A clinical and pathological study of twenty-eight cases, Am. J. Med., 53, 395-417 (1972).
34) Mc Garry, J. D. and Foster, D. W.: Regulation of ketogenenesis and clinical aspects of the ketotic state, Metabolism, 21, 471-489 (1972
33) Eaton, R. P.: Cobalt chloride-induced hyperlipemia in the rat: effects on intermediary metabolism, Am. J. Physiol., 222 1550-1557 (1972
14) Adrouny, G. A, and Russhel, J. A.: Effect of growth hormone and nutritional status on cardiac glycogen in the rat, Endocrinology, 59, 241-251 (1956).
28) Caplan, R. M. and Block, W. D.: Experimental production of hyperlipemia in rabbits by cobaltous chloride, J. Invest. Dermatol., 40, 199-203 (1963
3) Asano, S., Ohyama, K. and Koike, S.: Accumulation of triglyceride in rabbit liver induced by injection of cobalt chloride, Jap. J. Hyg., 27, 105 (1972).
22) Goldner, M. G., Volk, B. W. and Lazarus, S. S.: The effect of cobaltous chloride on the blood sugar and alpha cells in the pancreatic islets of the rabbit, Metabolism, 1, 544-548 (1952
18) Newsholme, E. A. and Randle, P. J.: Regulation of glucose uptake by muscle, 5. Effects of anoxia, insulin, adrenaline and prolonged starving on concentrations of hexose phosphate in isolated rat diaphragm and perfused isolated rat heart, Biochem. J., 80, 655-662 (1961
17) Opie, L. H. and Newsholme, E. A.: The activities of fructose-1,6-diphosphatase, phosphofructokinase and phosphoenolpyruvate carboxykinase in white muscle and red muscle, Biochem. J., 103, 391-399 (1967
16) Krebs, H. A. and Woodford, M.: Fructose-1,6-diphosphatase in striated muscle, Biochem. J., 94, 436-445 (1965
24) Fodden, J. H.: Experiments with chemicals noxious to the pancreatic alpha cells, Am. J. Clin. Path., 23, 1002-1011 (1953
27) Asano, S., Komaya, M. and Koike, S.: Hypertriglyceridemia and change of serum LDH activity in experimental animals injected with cobalt compound, Jap. J. Hyg., 25, 453-458 (1970
6) Hohorst, H-J.: D-Glucose-6-phosphat und D-Fructose-6-phosphat, in Methoden der enzymatischen Analyse, (Herausgeben von H. U. Bergmeyer) S. 1200. Verlag Chemie, Berlin (1970).
5) Bergmeyer, H. U., Bernt, E. Schmidt, F. und Stork, H.: Bestimmung der Glucose mit Hexokinase und Glucoe-6-phosphat-Dehydrogenase, in Methoden der enzymatischen Analyse, (Herausgeben von H. U. Bergmeyer) S. 1163, Verlag Chemie, Berlin (1970).
2) Hall, J. L. and Smith, E. B.: Cobalt heart disease, an electron microscopic and histochemical study in the rabbit, Arch. Path. 86, 403-412 (1968).
23) Volk, B. W., Lazarus, S. S. and Goldner, M. G.: Alpha cell damage and blood sugar changes in rabbits after administration of cobalt, Proc. Soc. Exp. Biol. Med., 82, 406-411. (1953
11) Olsen, C.: An enzymatic fluorimetric micromethod for the determination of acetoacetate, β-hydroxybutyrate, pyruvate and lactate, Clin. Chim. Acta, 33, 293-300 (1971
13) Evans, G.: J. Physiol. 82, 468 (1934).
References_xml – reference: 33) Eaton, R. P.: Cobalt chloride-induced hyperlipemia in the rat: effects on intermediary metabolism, Am. J. Physiol., 222 1550-1557 (1972)
– reference: 14) Adrouny, G. A, and Russhel, J. A.: Effect of growth hormone and nutritional status on cardiac glycogen in the rat, Endocrinology, 59, 241-251 (1956).
– reference: 1) Bonenfant, J-L., Miller, G. and Roy, P. E.: Quebec beer-drinkers' cardiomyopathy. Pathologic studies, Canad. Med. Assc. J. 97, 910-916 (1967).
– reference: 29) Robey, J. S., Veazey, P. M. and Crawford, J. D.: Cobalt-induced myxedema, Report of a case, New Engl. J. Med., 255, 955-957 (1956)
– reference: 6) Hohorst, H-J.: D-Glucose-6-phosphat und D-Fructose-6-phosphat, in Methoden der enzymatischen Analyse, (Herausgeben von H. U. Bergmeyer) S. 1200. Verlag Chemie, Berlin (1970).
– reference: 11) Olsen, C.: An enzymatic fluorimetric micromethod for the determination of acetoacetate, β-hydroxybutyrate, pyruvate and lactate, Clin. Chim. Acta, 33, 293-300 (1971)
– reference: 3) Asano, S., Ohyama, K. and Koike, S.: Accumulation of triglyceride in rabbit liver induced by injection of cobalt chloride, Jap. J. Hyg., 27, 105 (1972).
– reference: 8) Folch, J., Lees, M. and Sloane, G. H.: A simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem., 226, 479-506 (1957).
– reference: 16) Krebs, H. A. and Woodford, M.: Fructose-1,6-diphosphatase in striated muscle, Biochem. J., 94, 436-445 (1965)
– reference: 23) Volk, B. W., Lazarus, S. S. and Goldner, M. G.: Alpha cell damage and blood sugar changes in rabbits after administration of cobalt, Proc. Soc. Exp. Biol. Med., 82, 406-411. (1953)
– reference: 26) Fodden, J. H. and Read, W. H.: The activity of extracted pancreatic hyperglycemic-glycogenolytic factor after cobaltous chloride and synthalin A, Endocrinology, 54, 303-310 (1944)
– reference: 19) Cahill, G. F. Jr., Ashmore, J., Renold, A. E. and Hasting, A. B.: Blood glucose and liver, Am. J. Med., 26, 264-282 (1959)
– reference: 30) Caplan, R. and Curtis, A.: Xanthoma of the skin, J. Am. Med. Assoc., 176, 859-863 (1961)
– reference: 13) Evans, G.: J. Physiol. 82, 468 (1934).
– reference: 17) Opie, L. H. and Newsholme, E. A.: The activities of fructose-1,6-diphosphatase, phosphofructokinase and phosphoenolpyruvate carboxykinase in white muscle and red muscle, Biochem. J., 103, 391-399 (1967)
– reference: 7) Bücher, J. und Hohorst, H. J.: D-Fructose-1, 6-diphosphat, Dihydroxyaceton-phosphat und D-Glycerinaldehyd-3-phosphat, in Methoden der enzymatischen Analyse, (Herausgeben von H. U. Bergmeyer) S. 1282, Verlag Chemie, Berlin (1970)
– reference: 21) Start, C. and Newsholme, E. A.: The effects of starvation and alloxan-diabetes on the contents of citrate and other metabolic intermediates in rat liver, Biochem. J., 107, 411-415 (1968).
– reference: 4) Seifter, S., Dayton, S., Novic, B. and Muntwyler, E.: The determination of glycogen with the anthrone reagent, Arch. Biochem. Biophys., 25, 191-200 (1951).
– reference: 31) Havel, R. J., Felts, J. M. and Van Duyne, C. M.: Formation and fate of endogenous triglycerides in blood plasma of rabbits, J. Lip. Res., 3, 297-308 (1962)
– reference: 28) Caplan, R. M. and Block, W. D.: Experimental production of hyperlipemia in rabbits by cobaltous chloride, J. Invest. Dermatol., 40, 199-203 (1963)
– reference: 27) Asano, S., Komaya, M. and Koike, S.: Hypertriglyceridemia and change of serum LDH activity in experimental animals injected with cobalt compound, Jap. J. Hyg., 25, 453-458 (1970)
– reference: 24) Fodden, J. H.: Experiments with chemicals noxious to the pancreatic alpha cells, Am. J. Clin. Path., 23, 1002-1011 (1953)
– reference: 32) Masora, E. J.: Physiological chemistry of lipids in mammales, P. 218, Saunders Comp. Philadelphia (1968)
– reference: 25) Lochner, J. V., Eisentraut, A. M. and Unger, R.H.: The effect of CoCl2 on glucagon levels in plasma and pancreas of the rat, Metabolism, 13, 868-874 (1964)
– reference: 22) Goldner, M. G., Volk, B. W. and Lazarus, S. S.: The effect of cobaltous chloride on the blood sugar and alpha cells in the pancreatic islets of the rabbit, Metabolism, 1, 544-548 (1952)
– reference: 2) Hall, J. L. and Smith, E. B.: Cobalt heart disease, an electron microscopic and histochemical study in the rabbit, Arch. Path. 86, 403-412 (1968).
– reference: 5) Bergmeyer, H. U., Bernt, E. Schmidt, F. und Stork, H.: Bestimmung der Glucose mit Hexokinase und Glucoe-6-phosphat-Dehydrogenase, in Methoden der enzymatischen Analyse, (Herausgeben von H. U. Bergmeyer) S. 1163, Verlag Chemie, Berlin (1970).
– reference: 10) Laurell, S. and Tibbling, G.: Colorimetric microdetermination of free fatty acids in plasma, Clin. Chim. Acta, 16, 57-62 (1967).
– reference: 36) Alexander, C. S.: Cobalt and the heart, Annals Int. Med., 70, 411-413 (1969)
– reference: 34) Mc Garry, J. D. and Foster, D. W.: Regulation of ketogenenesis and clinical aspects of the ketotic state, Metabolism, 21, 471-489 (1972)
– reference: 35) Webb, M.: The biological action of cobalt and other metals, III. Chelation of cations by dihydroxylipoic acid, Biochim. Biophys. Acta, 65, 47-65 (1962)
– reference: 15) Jedeikin, L. A.: Cardiac glycogen metabolism in vivo in fed and starved rats, Biochem. J., 99, 6p (1966).
– reference: 9) Eggstein, M. und Kuhlmann, E: Triglyceride und Glycerin, in Methoden der enzymatischen Analyse (Herausgeben von H. U. Bergmeyer) S. 1765, Verlag Chemie, Berlin (1970).
– reference: 12) Alexander, C. S.: Cobalt cardiomyopathy, A clinical and pathological study of twenty-eight cases, Am. J. Med., 53, 395-417 (1972).
– reference: 20) Steiner, D. F. and Williams, R. H.: Some observations concerning hepatic glucose-6-phosphate content in normal and diabetic rats, J. Biol. Chem., 234, 1342-1346 (1959)
– reference: 18) Newsholme, E. A. and Randle, P. J.: Regulation of glucose uptake by muscle, 5. Effects of anoxia, insulin, adrenaline and prolonged starving on concentrations of hexose phosphate in isolated rat diaphragm and perfused isolated rat heart, Biochem. J., 80, 655-662 (1961)
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