放射線治療後に硬膜転移を含む髄腔内播種再発をきたした中枢神経原発組織球性肉腫 症例報告と文献レビュー
中枢神経原発組織球性肉腫はきわめてまれであり, 症例報告も限られ, 予後因子や治療法も確立されていない. 術後放射線治療後の再発病変に対してMPV療法が奏効した1例を報告する. また, 本疾患の治療戦略を探るべく, 渉猟した文献症例と当症例を合わせた33症例の臨床データを解析し, 予後因子と治療法の効果予測因子を評価した. 結果, 多発病変は生存期間が短い傾向にあった. 肉眼的全摘出と放射線治療が有意な予後延長因子であった. 化学療法の有意性は認めなかったが, 化学放射線療法群はおのおのの単独治療群よりも生存期間が延長した. 本疾患の生存期間延長には肉眼的全切除が望ましく, 化学療法を含めた集...
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| Published in | 脳神経外科ジャーナル Vol. 33; no. 5; pp. 356 - 363 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人日本脳神経外科コングレス
2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0917-950X 2187-3100 |
| DOI | 10.7887/jcns.33.356 |
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| Abstract | 中枢神経原発組織球性肉腫はきわめてまれであり, 症例報告も限られ, 予後因子や治療法も確立されていない. 術後放射線治療後の再発病変に対してMPV療法が奏効した1例を報告する. また, 本疾患の治療戦略を探るべく, 渉猟した文献症例と当症例を合わせた33症例の臨床データを解析し, 予後因子と治療法の効果予測因子を評価した. 結果, 多発病変は生存期間が短い傾向にあった. 肉眼的全摘出と放射線治療が有意な予後延長因子であった. 化学療法の有意性は認めなかったが, 化学放射線療法群はおのおのの単独治療群よりも生存期間が延長した. 本疾患の生存期間延長には肉眼的全切除が望ましく, 化学療法を含めた集学的治療の有効性も示唆された. |
|---|---|
| AbstractList | 中枢神経原発組織球性肉腫はきわめてまれであり, 症例報告も限られ, 予後因子や治療法も確立されていない. 術後放射線治療後の再発病変に対してMPV療法が奏効した1例を報告する. また, 本疾患の治療戦略を探るべく, 渉猟した文献症例と当症例を合わせた33症例の臨床データを解析し, 予後因子と治療法の効果予測因子を評価した. 結果, 多発病変は生存期間が短い傾向にあった. 肉眼的全摘出と放射線治療が有意な予後延長因子であった. 化学療法の有意性は認めなかったが, 化学放射線療法群はおのおのの単独治療群よりも生存期間が延長した. 本疾患の生存期間延長には肉眼的全切除が望ましく, 化学療法を含めた集学的治療の有効性も示唆された. |
| Author | 秦, 暢宏 川﨑, ゆかり 大西, 晃平 藤木, 稔 松下, 航 籾井, 泰朋 阿南, 光洋 髙尾, 薫平 |
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| References | 3) Bell SL, Hanzely Z, Alakandy LM, Jackson R, Stewart W : Primary meningeal histiocytic sarcoma : a report of two unusual cases. Neuropathol Appl Neurobiol 38 : 111-114, 2012. 28) Zuo P, Zhang M, Wu W, Wang Y, Li T, Sun T, Wang Y, Wu Z, Zhang J, Zhang L : Primary intracranial histiocytic sarcomas : a report of six cases and a pooled analysis of individual patient data. J Cancer Res Clin Oncol 149 : 12071-12079, 2023. 10) Gill-Samra S, Ng T, Dexter M, Wong M, Nahar N, Allsopp K, Boadle RA, Varikatt W : Histiocytic sarcoma of the brain. J Clin Neurosci 19 : 1456-1458, 2012. 16) May JM, Waddle MR, Miller DH, Stross WC, Kaleem TA, May BC, Miller RC, Jiang L, Strong GW, Trifiletti DM, Chaichana KL, Reimer R, Tun HW, Peterson JL : Primary histiocytic sarcoma of the central nervous system : a case report with platelet derived growth factor receptor mutation and PD-L1/PD-L2 expression and literature review. Radiat Oncol 13 : 167, 2018. 11) Gomi K, Tanaka M, Yoshida M, Ito S, Sonoda M, Iwasaki F, Niwa T, Aida N, Kigasawa H, Tanaka Y : Primary cerebellar histiocytic sarcoma in a 17-month-old girl. J Neurosurg Pediatr 10 : 126-129, 2012. 5) Cao M, Eshoa C, Schultz C, Black J, Zu Y, Chang CC : Primary central nervous system histiocytic sarcoma with relapse to mediastinum : a case report and review of the literature. Arch Pathol Lab Med 131 : 301-305, 2007. 27) Zanelli M, Ragazzi M, Marchetti G, Bisagni A, Principi M, Fanni D, Froio E, Serra S, Zanetti E, De Marco L, Giangaspero F, Ascani S : Primary histiocytic sarcoma presenting as diffuse leptomeningeal disease : case description and review of the literature. Neuropathology 37 : 517-525, 2017. 7) Cheuk W, Walford N, Lou J, Lee AK, Fung CF, Au KH, Mak LS, Chan JK : Primary histiocytic lymphoma of the central nervous system : a neoplasm frequently overshadowed by a prominent inflammatory component. Am J Surg Pathol 25 : 1372-1379, 2001. 24) Uno R, Kanzawa M, Tanaka K, Sasayama T, Kodama Y, Hirose T, Itoh T : A case of primary histiocytic sarcoma of the central nervous system. Human Pathology Reports 29 : 300664, 2022. 13) Laviv Y, Zagzag D, Fichman-Horn S, Michowitz S : Primary central nervous system histiocytic sarcoma. Brain Tumor Pathol 30 : 192-195, 2013. 23) Ueno T, Nishijima H, Kurotaki H, Kurose A, Tomiyama M : An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. Neurol Sci 37 : 1875-1877, 2016. 18) Pérez-Ruiz E, Delgado M, Sanz A, Gil AM, Domínguez AR : Primary leptomeningeal histiocytic sarcoma in a patient with a good outcome : a case report and review of the literature. J Med Case Rep 7 : 127, 2013. 14) Ma S, Schild M, Tran D, Zhang X, Zhang WL, Shen S, Xu HT, Yang LH, Wang E : Primary central nervous system histiocytic sarcoma : a case report and review of literature. Medicine (Baltimore) 97 : e11271, 2018. 1) Almefty RO, Tyree TL, Fusco DJ, Coons SW, Nakaji P : Primary histiocytic sarcoma of the brain mimicking cerebral abscess. J Neurosurg Pediatr 12 : 251-257, 2013. 15) Marguet F, Piton N, Adle-Biassette H, Renaud F, Bohers E, Boyer T, Zarea A, Derrey S, Sabourin JC, Laquerrière A : Molecular characteristics of multifocal brain histiocytic sarcoma. Neuropathol Appl Neurobiol 45 : 309-313, 2019. 6) Chen CJ, Williams E, McAneney TE, Williams BJ, Mandell JW, Shaffrey ME : Histiocytic sarcoma of the cavernous sinus : case report and literature review. Brain Tumor Pathol 32 : 66-71, 2015. 2) Bai J, Li G, Shen M, Sui D, Lin S : Primary central nervous system histiocytic sarcoma mimicking glioma. Neurol India 62 : 684-685, 2014. 8) Devic P, Androdias-Condemine G, Streichenberger N, Berger F, Honnorat J, Broussolle E, Thobois S : Histiocytic sarcoma of the central nervous system : a challenging diagnosis. QJM 105 : 77-79, 2012. 17) Moulignier A, Mikol J, Heran F, Galicier L : Isolated III cranial nerve palsies may point to primary histiocytic sarcoma. BMJ Case Rep Aug 14 : bcr2014204663, 2014. 25) Wang J, Li T, Chen H, Liu Q : A case of primary central nervous system histiocytic sarcoma. Clin Neurol Neurosurg 114 : 1074-1076, 2012. 9) Foster M, Kamaly-Asl I, Stivaros S, Kelsey A, Gattamenini R, Kilday JP : Primary cerebral histiocytic sarcoma in childhood : a case report of protracted survival and review of the literature. Childs Nerv Syst 31 : 2363-2368, 2015. 4) Brown AF, Fan H, Floyd JR, Henry JM, Higgins RA : Primary central nervous system histiocytic sarcoma arising after precursor B-cell acute lymphoblastic leukemia. J Neuropathol Exp Neurol 74 : 1120-1126, 2015. 19) Rogawski DS, Nirschl JJ, McDonald J, Nie E, Schwartz NU, Vogel H, Scott BJ, Gold CA, Kipp LB : A rare neuromyelitis optica mimic : primary CNS histiocytic sarcoma. Mult Scler 28 : 1651-1654, 2022. 26) Wu W, Tanrivermis Sayit A, Vinters HV, Pope W, Mirsadraei L, Said J : Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma : case report and literature review. Hum Pathol 44 : 1177-1183, 2013. 21) Shahrokh S, Rakhsha A, Shahin M, Javadzadegan A, Ahadi M, Azghandi S, Taghizadeh-Hesary F : Successful treatment of central nervous system histiocytic sarcoma with craniectomy and adjuvant radiotherapy. Cureus 14 : e24690, 2022. 12) Idbaih A, Mokhtari K, Emile JF, Galanaud D, Belaid H, de Bernard S, Benameur N, Barlog VC, Psimaras D, Donadieu J, Carpentier C, Martin-Duverneuil N, Haroche J, Feuvret L, Zahr N, Delattre JY, Hoang-Xuan K : Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib. Neurology 83 : 1478-1480, 2014. 20) So H, Kim SA, Yoon DH, Khang SK, Hwang J, Suh CH, Suh C : Primary histiocytic sarcoma of the central nervous system. Cancer Res Treat 47 : 322-328, 2015. 22) Toshkezi G, Edalat F, O'Hara C, Delalle I, Chin LS : Primary intramedullary histiocytic sarcoma. World Neurosurg 74 : 523-527, 2010. |
| References_xml | – reference: 27) Zanelli M, Ragazzi M, Marchetti G, Bisagni A, Principi M, Fanni D, Froio E, Serra S, Zanetti E, De Marco L, Giangaspero F, Ascani S : Primary histiocytic sarcoma presenting as diffuse leptomeningeal disease : case description and review of the literature. Neuropathology 37 : 517-525, 2017. – reference: 7) Cheuk W, Walford N, Lou J, Lee AK, Fung CF, Au KH, Mak LS, Chan JK : Primary histiocytic lymphoma of the central nervous system : a neoplasm frequently overshadowed by a prominent inflammatory component. Am J Surg Pathol 25 : 1372-1379, 2001. – reference: 19) Rogawski DS, Nirschl JJ, McDonald J, Nie E, Schwartz NU, Vogel H, Scott BJ, Gold CA, Kipp LB : A rare neuromyelitis optica mimic : primary CNS histiocytic sarcoma. Mult Scler 28 : 1651-1654, 2022. – reference: 6) Chen CJ, Williams E, McAneney TE, Williams BJ, Mandell JW, Shaffrey ME : Histiocytic sarcoma of the cavernous sinus : case report and literature review. Brain Tumor Pathol 32 : 66-71, 2015. – reference: 17) Moulignier A, Mikol J, Heran F, Galicier L : Isolated III cranial nerve palsies may point to primary histiocytic sarcoma. BMJ Case Rep Aug 14 : bcr2014204663, 2014. – reference: 8) Devic P, Androdias-Condemine G, Streichenberger N, Berger F, Honnorat J, Broussolle E, Thobois S : Histiocytic sarcoma of the central nervous system : a challenging diagnosis. QJM 105 : 77-79, 2012. – reference: 10) Gill-Samra S, Ng T, Dexter M, Wong M, Nahar N, Allsopp K, Boadle RA, Varikatt W : Histiocytic sarcoma of the brain. J Clin Neurosci 19 : 1456-1458, 2012. – reference: 22) Toshkezi G, Edalat F, O'Hara C, Delalle I, Chin LS : Primary intramedullary histiocytic sarcoma. World Neurosurg 74 : 523-527, 2010. – reference: 9) Foster M, Kamaly-Asl I, Stivaros S, Kelsey A, Gattamenini R, Kilday JP : Primary cerebral histiocytic sarcoma in childhood : a case report of protracted survival and review of the literature. Childs Nerv Syst 31 : 2363-2368, 2015. – reference: 24) Uno R, Kanzawa M, Tanaka K, Sasayama T, Kodama Y, Hirose T, Itoh T : A case of primary histiocytic sarcoma of the central nervous system. Human Pathology Reports 29 : 300664, 2022. – reference: 4) Brown AF, Fan H, Floyd JR, Henry JM, Higgins RA : Primary central nervous system histiocytic sarcoma arising after precursor B-cell acute lymphoblastic leukemia. J Neuropathol Exp Neurol 74 : 1120-1126, 2015. – reference: 5) Cao M, Eshoa C, Schultz C, Black J, Zu Y, Chang CC : Primary central nervous system histiocytic sarcoma with relapse to mediastinum : a case report and review of the literature. Arch Pathol Lab Med 131 : 301-305, 2007. – reference: 1) Almefty RO, Tyree TL, Fusco DJ, Coons SW, Nakaji P : Primary histiocytic sarcoma of the brain mimicking cerebral abscess. J Neurosurg Pediatr 12 : 251-257, 2013. – reference: 13) Laviv Y, Zagzag D, Fichman-Horn S, Michowitz S : Primary central nervous system histiocytic sarcoma. Brain Tumor Pathol 30 : 192-195, 2013. – reference: 11) Gomi K, Tanaka M, Yoshida M, Ito S, Sonoda M, Iwasaki F, Niwa T, Aida N, Kigasawa H, Tanaka Y : Primary cerebellar histiocytic sarcoma in a 17-month-old girl. J Neurosurg Pediatr 10 : 126-129, 2012. – reference: 28) Zuo P, Zhang M, Wu W, Wang Y, Li T, Sun T, Wang Y, Wu Z, Zhang J, Zhang L : Primary intracranial histiocytic sarcomas : a report of six cases and a pooled analysis of individual patient data. J Cancer Res Clin Oncol 149 : 12071-12079, 2023. – reference: 16) May JM, Waddle MR, Miller DH, Stross WC, Kaleem TA, May BC, Miller RC, Jiang L, Strong GW, Trifiletti DM, Chaichana KL, Reimer R, Tun HW, Peterson JL : Primary histiocytic sarcoma of the central nervous system : a case report with platelet derived growth factor receptor mutation and PD-L1/PD-L2 expression and literature review. Radiat Oncol 13 : 167, 2018. – reference: 14) Ma S, Schild M, Tran D, Zhang X, Zhang WL, Shen S, Xu HT, Yang LH, Wang E : Primary central nervous system histiocytic sarcoma : a case report and review of literature. Medicine (Baltimore) 97 : e11271, 2018. – reference: 21) Shahrokh S, Rakhsha A, Shahin M, Javadzadegan A, Ahadi M, Azghandi S, Taghizadeh-Hesary F : Successful treatment of central nervous system histiocytic sarcoma with craniectomy and adjuvant radiotherapy. Cureus 14 : e24690, 2022. – reference: 12) Idbaih A, Mokhtari K, Emile JF, Galanaud D, Belaid H, de Bernard S, Benameur N, Barlog VC, Psimaras D, Donadieu J, Carpentier C, Martin-Duverneuil N, Haroche J, Feuvret L, Zahr N, Delattre JY, Hoang-Xuan K : Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib. Neurology 83 : 1478-1480, 2014. – reference: 2) Bai J, Li G, Shen M, Sui D, Lin S : Primary central nervous system histiocytic sarcoma mimicking glioma. Neurol India 62 : 684-685, 2014. – reference: 3) Bell SL, Hanzely Z, Alakandy LM, Jackson R, Stewart W : Primary meningeal histiocytic sarcoma : a report of two unusual cases. Neuropathol Appl Neurobiol 38 : 111-114, 2012. – reference: 20) So H, Kim SA, Yoon DH, Khang SK, Hwang J, Suh CH, Suh C : Primary histiocytic sarcoma of the central nervous system. Cancer Res Treat 47 : 322-328, 2015. – reference: 25) Wang J, Li T, Chen H, Liu Q : A case of primary central nervous system histiocytic sarcoma. Clin Neurol Neurosurg 114 : 1074-1076, 2012. – reference: 26) Wu W, Tanrivermis Sayit A, Vinters HV, Pope W, Mirsadraei L, Said J : Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma : case report and literature review. Hum Pathol 44 : 1177-1183, 2013. – reference: 18) Pérez-Ruiz E, Delgado M, Sanz A, Gil AM, Domínguez AR : Primary leptomeningeal histiocytic sarcoma in a patient with a good outcome : a case report and review of the literature. J Med Case Rep 7 : 127, 2013. – reference: 15) Marguet F, Piton N, Adle-Biassette H, Renaud F, Bohers E, Boyer T, Zarea A, Derrey S, Sabourin JC, Laquerrière A : Molecular characteristics of multifocal brain histiocytic sarcoma. Neuropathol Appl Neurobiol 45 : 309-313, 2019. – reference: 23) Ueno T, Nishijima H, Kurotaki H, Kurose A, Tomiyama M : An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. Neurol Sci 37 : 1875-1877, 2016. |
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| Snippet | 中枢神経原発組織球性肉腫はきわめてまれであり, 症例報告も限られ, 予後因子や治療法も確立されていない. 術後放射線治療後の再発病変に対してMPV療法が奏効した1例を報告する. また, 本疾患の治療戦略を探るべく, 渉猟した文献症例と当症例を合わせた33症例の臨床データを解析し,... |
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| SubjectTerms | central nervous system histiocytic sarcoma multidisciplinary treatment |
| Subtitle | 症例報告と文献レビュー |
| Title | 放射線治療後に硬膜転移を含む髄腔内播種再発をきたした中枢神経原発組織球性肉腫 |
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