Photosensitivity Induced by Flutamide (Odyne®)

• Published in: Skin research Vol. 39; no. 6; pp. 575 - 578
• Main Authors: NAKAMURA, Atsuko, TANI, Masahiro
• Format: Journal Article
• Language: English; Japanese
• Published: Meeting of Osaka Dermatological Association 1997; 日本皮膚科学会大阪地方会
• Subjects: drug eruption; flutamide; Odyne; photosensitivity; オダイン; フルタミド; 光線過敏症; 薬疹
• ISSN: 0018-1390; 1884-541X
• DOI: 10.11340/skinresearch1959.39.575

We present a 76-year-old man who had a photosensitive reaction induced by flutamide, which was confirmed by phototestings and readministration test. He had been given flutamide (Odyne®) for prostatic carcinoma since December 1995. In March 1996, he developed pruritic, lichenified erythema on the sun-exposed areas. Phototestings disclosed that the patient's UVA MED was reduced. Flutamide was discontinued. Over the next 40 days, the eruption cleared and the UVA MED became normal. A test dose of flutamide was given with his consent. Two days after oral readministration of flutamide he noted pruritic erythematous macules developing on his face, neck, and the dorsal aspects of his hands. There have been only few reports of eruptions that occurred as an adverse side effect of therapy with flutamide. Since flutamide is frequently used for the treatment of prostatic carcinoma, it should be listed among those drugs capable of inducing photosensitivity.