鼻腔NK/T細胞性リンパ腫の組織学的および分子生物学的検討
1991年から2003年にかけて鼻腔NK/T細胞性およびT細胞性悪性リンパ腫と診断された症例の組織標本に対してモノクローナル抗体 (CD2, CD3, CD5, CD56) を用いた免疫組織化学的染色による表現型の確認とEBV潜伏感染遺伝子 (EBNA1, EBNA2, ZEBRA) の検索, in situ hybridizationによるEBERの検索を行った。そのうち3例についてはPCR法によるT細胞レセプター (TCR) 遺伝子再構築の検索を行った。過去にT細胞性と診断された7例のうち, 4例がCD56陽性となり, NK/T細胞性であった可能性が高くなった。EBVの検索ではEBNA1と...
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| Published in | 耳鼻咽喉科展望 Vol. 50; no. 2; pp. 82 - 88 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
耳鼻咽喉科展望会
15.04.2007
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0386-9687 1883-6429 |
| DOI | 10.11453/orltokyo1958.50.82 |
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| Abstract | 1991年から2003年にかけて鼻腔NK/T細胞性およびT細胞性悪性リンパ腫と診断された症例の組織標本に対してモノクローナル抗体 (CD2, CD3, CD5, CD56) を用いた免疫組織化学的染色による表現型の確認とEBV潜伏感染遺伝子 (EBNA1, EBNA2, ZEBRA) の検索, in situ hybridizationによるEBERの検索を行った。そのうち3例についてはPCR法によるT細胞レセプター (TCR) 遺伝子再構築の検索を行った。過去にT細胞性と診断された7例のうち, 4例がCD56陽性となり, NK/T細胞性であった可能性が高くなった。EBVの検索ではEBNA1とEBERが高率に陽性を示したが, EBNA 2とZEBRAは全例陰性であった。以上より, NK/T細胞性リンパ腫と診断されたものの中にNK細胞由来のものとT細胞由来のものが潜在すると考えられた。 |
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| AbstractList | 1991年から2003年にかけて鼻腔NK/T細胞性およびT細胞性悪性リンパ腫と診断された症例の組織標本に対してモノクローナル抗体 (CD2, CD3, CD5, CD56) を用いた免疫組織化学的染色による表現型の確認とEBV潜伏感染遺伝子 (EBNA1, EBNA2, ZEBRA) の検索, in situ hybridizationによるEBERの検索を行った。そのうち3例についてはPCR法によるT細胞レセプター (TCR) 遺伝子再構築の検索を行った。過去にT細胞性と診断された7例のうち, 4例がCD56陽性となり, NK/T細胞性であった可能性が高くなった。EBVの検索ではEBNA1とEBERが高率に陽性を示したが, EBNA 2とZEBRAは全例陰性であった。以上より, NK/T細胞性リンパ腫と診断されたものの中にNK細胞由来のものとT細胞由来のものが潜在すると考えられた。 |
| Author | 高田, 大輔 吉田, 知之 伊藤, 博之 鈴木, 衞 |
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| References | 12) Ko YH, Cho EY, Kim JE, Lee SS, Huh JR, et al : NK and NK-like T-cell lymphoma in extranasal sites : a comparative clinicopathological study according to site and EBV status. Histopathology 44 : 480-489, 2004. 7) Zhang Q, Gutsch D, Kenney S : Functional and physical interaction between p53 and BZLF1 : implications for Epstein-Barr virus latency. Mol Cell Biol 14 : 1929-1938, 1994. 1) Harabuchi Y, Imai S, Wakashima J, Hirao M, Kataura A, et al : Nasal T-cell lymphoma causally associated with Epstein-Barr virus. Cancer 77 : 2137-2149, 1996. 5) Chiang AKS, Chan ACL, Srivastava G, Ho FCS : Nasal T/Natural killer (NK) -cell lymphomas are derived from Epsrein-Barr virus infected cytotoxic lymphocytes of both NK-and T-cell lineage. Int J Cancer 73 : 332-338, 1997. 3) Nagata H, Konno A, Kimura N, Zhang Y, Kimura N, et al : Characterization of novel natural killer (NK) -cell and gammadelta T-cell lines established from primary lesions of nasal T/NK-cell lymphomas associated with the Epstein-Barr virus. Blood 97 : 708-713, 2001. 11) Argyrakos T, Rontgianni D, Karmiris T, Kapsimali V, Grigoriou E, et al : Blastic natural killer (NK) -cell lymphoma : report of an unusual CD4 negative case and review of the CD4 negative neoplasms with blastic features in the literature.Leuk Lymphoma 45 : 2127-2133, 2004. 8) Dreyfus DH, Nagasawa M, Kelleher CA, Gelfand EW : Stable expression of Epstein-Barr virus BZLF-1-encoded ZEBRA protein activates p53-dependent transcription in human Jurkat T-lymphoblastoid cells. Blood 96 : 625-634, 2000. 2) Wiedorn KH, Kuhl H, Galle J, Caselitz J, Vollmer E : Comparison of in-situ hybridization, direct and indirect in-situ PCR as well as tyramide signal amplification for the detection of HPV. Histochem Cell Biol 111 : 89-95, 1999. 4) Yoon TY, Lee HT, Chang SH : Nasal-type T/ Natural killer cell angiocentric lymphoma, Epstein-Barr virus-associated, and showing clonal T-cell receptor gamma gene rearrangement. BR J Dermatol 140 : 505-508, 1999. 9) Xu ZG, Iwatsuki K, Oyama N, Ohtsuka M, Satoh M, et al : The latency pattern of Epstein-Barr virus infection and viral IL-10 expression in cutaneous natural killer/T-cell lymphomas. BR J Cancer 84 : 920-925, 2001. 13) Lei KIK, Chan LYS, Chan WY, Johnson PJ, Lo YMD : Diagnostic and prognostic implications of circulating cell-free Epstein-Barr virus DNA in natural Killer/T-cell lymphoma. Clin Cancer Res 8 : 29-34, 2002. 10) Chiang AK, Tao Q, Srivastava G, Ho FCS : Nasal NK-and T-cell lymphomas share the same type of Epstein-Barr virus latency as nasopharyngeal carcinoma and Hodgkin's disease. Int J Cancer 68 : 285-290, 1996. 6) 西連寺剛 : EBウイルス感染と発がん.ウイルス52 : 273-279, 2002. |
| References_xml | – reference: 3) Nagata H, Konno A, Kimura N, Zhang Y, Kimura N, et al : Characterization of novel natural killer (NK) -cell and gammadelta T-cell lines established from primary lesions of nasal T/NK-cell lymphomas associated with the Epstein-Barr virus. Blood 97 : 708-713, 2001. – reference: 2) Wiedorn KH, Kuhl H, Galle J, Caselitz J, Vollmer E : Comparison of in-situ hybridization, direct and indirect in-situ PCR as well as tyramide signal amplification for the detection of HPV. Histochem Cell Biol 111 : 89-95, 1999. – reference: 13) Lei KIK, Chan LYS, Chan WY, Johnson PJ, Lo YMD : Diagnostic and prognostic implications of circulating cell-free Epstein-Barr virus DNA in natural Killer/T-cell lymphoma. Clin Cancer Res 8 : 29-34, 2002. – reference: 8) Dreyfus DH, Nagasawa M, Kelleher CA, Gelfand EW : Stable expression of Epstein-Barr virus BZLF-1-encoded ZEBRA protein activates p53-dependent transcription in human Jurkat T-lymphoblastoid cells. Blood 96 : 625-634, 2000. – reference: 1) Harabuchi Y, Imai S, Wakashima J, Hirao M, Kataura A, et al : Nasal T-cell lymphoma causally associated with Epstein-Barr virus. Cancer 77 : 2137-2149, 1996. – reference: 6) 西連寺剛 : EBウイルス感染と発がん.ウイルス52 : 273-279, 2002. – reference: 9) Xu ZG, Iwatsuki K, Oyama N, Ohtsuka M, Satoh M, et al : The latency pattern of Epstein-Barr virus infection and viral IL-10 expression in cutaneous natural killer/T-cell lymphomas. BR J Cancer 84 : 920-925, 2001. – reference: 11) Argyrakos T, Rontgianni D, Karmiris T, Kapsimali V, Grigoriou E, et al : Blastic natural killer (NK) -cell lymphoma : report of an unusual CD4 negative case and review of the CD4 negative neoplasms with blastic features in the literature.Leuk Lymphoma 45 : 2127-2133, 2004. – reference: 5) Chiang AKS, Chan ACL, Srivastava G, Ho FCS : Nasal T/Natural killer (NK) -cell lymphomas are derived from Epsrein-Barr virus infected cytotoxic lymphocytes of both NK-and T-cell lineage. Int J Cancer 73 : 332-338, 1997. – reference: 7) Zhang Q, Gutsch D, Kenney S : Functional and physical interaction between p53 and BZLF1 : implications for Epstein-Barr virus latency. Mol Cell Biol 14 : 1929-1938, 1994. – reference: 12) Ko YH, Cho EY, Kim JE, Lee SS, Huh JR, et al : NK and NK-like T-cell lymphoma in extranasal sites : a comparative clinicopathological study according to site and EBV status. Histopathology 44 : 480-489, 2004. – reference: 4) Yoon TY, Lee HT, Chang SH : Nasal-type T/ Natural killer cell angiocentric lymphoma, Epstein-Barr virus-associated, and showing clonal T-cell receptor gamma gene rearrangement. BR J Dermatol 140 : 505-508, 1999. – reference: 10) Chiang AK, Tao Q, Srivastava G, Ho FCS : Nasal NK-and T-cell lymphomas share the same type of Epstein-Barr virus latency as nasopharyngeal carcinoma and Hodgkin's disease. Int J Cancer 68 : 285-290, 1996. |
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| Title | 鼻腔NK/T細胞性リンパ腫の組織学的および分子生物学的検討 |
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