大腸癌進展におけるinterleukin-6の検討 悪性度指標としての意義
目的: Interleukin-6 (IL-6) の血中レベルと大腸癌のリンパ節転移・肝転移との関連性および予後に及ぼす影響を検討し, IL-6の悪性度指標としての意義を明らかにする. 方法: 大腸癌65例を対象とし, 健常者20例を対照とした. IL-6の術前血清値 (pg/ml) について1) Dukes分類, 2) リンパ節転移 (n), 3) 肝転移 (H'), 4) IL-6関連サイトカイン, 5) 転移関連接着因子との関連性を検討した. 6) 非リンパ節転移・非肝転移群25 例のIL-6値 (平均値+2SD) より仮のカットオフ値 (5.81) を設定し, 2群間の累積生...
Saved in:
| Published in | 日本消化器外科学会雑誌 Vol. 37; no. 6; pp. 656 - 662 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本消化器外科学会
2004
|
| Online Access | Get full text |
| ISSN | 0386-9768 1348-9372 |
| DOI | 10.5833/jjgs.37.656 |
Cover
| Abstract | 目的: Interleukin-6 (IL-6) の血中レベルと大腸癌のリンパ節転移・肝転移との関連性および予後に及ぼす影響を検討し, IL-6の悪性度指標としての意義を明らかにする. 方法: 大腸癌65例を対象とし, 健常者20例を対照とした. IL-6の術前血清値 (pg/ml) について1) Dukes分類, 2) リンパ節転移 (n), 3) 肝転移 (H'), 4) IL-6関連サイトカイン, 5) 転移関連接着因子との関連性を検討した. 6) 非リンパ節転移・非肝転移群25 例のIL-6値 (平均値+2SD) より仮のカットオフ値 (5.81) を設定し, 2群間の累積生存率を全症例およびステージ別(III, IV) に比較した. 7) 腫瘍組織におけるIL-6の発現性を検索した. 結果: 1) Dukes C群, D群のIL-6平均値 (7.12, 18.57)は, 対照群 (1.05) と比較して有意に高値であった. 2) IL-6値とリンパ節転移度および肝転移の有無の間に有意な相関を認め, n2, 3 (+) 群の平均値 (10.20, 14.23) は, n (-) 群 (3.27) と比較して有意に高値であった. また, H'(+) 群の平均値 (18.57) はH0'群 (4.93) と比較して有意に高値であった. 3) IL-6値とHGF, ICAM-1, VCAM-1, E-selectinとの間に有意な相関を認めた. 4) IL-6値5.81以上を陽性とした場合, 全症例およびステージ別比較においてIL-6 高値群の累積生存率は低値群に比べ有意に不良であった. 5) IL-6 25pg/ml以上の全症例の腫瘍細胞質にIL-6の陽性所見を認めた. 結論: IL-6は大腸癌のリンパ節転移・肝転移成立に促進的に関与することが示唆され, その血清値は予後をよく反映し悪性度指標になりえる. |
|---|---|
| AbstractList | 目的: Interleukin-6 (IL-6) の血中レベルと大腸癌のリンパ節転移・肝転移との関連性および予後に及ぼす影響を検討し, IL-6の悪性度指標としての意義を明らかにする. 方法: 大腸癌65例を対象とし, 健常者20例を対照とした. IL-6の術前血清値 (pg/ml) について1) Dukes分類, 2) リンパ節転移 (n), 3) 肝転移 (H'), 4) IL-6関連サイトカイン, 5) 転移関連接着因子との関連性を検討した. 6) 非リンパ節転移・非肝転移群25 例のIL-6値 (平均値+2SD) より仮のカットオフ値 (5.81) を設定し, 2群間の累積生存率を全症例およびステージ別(III, IV) に比較した. 7) 腫瘍組織におけるIL-6の発現性を検索した. 結果: 1) Dukes C群, D群のIL-6平均値 (7.12, 18.57)は, 対照群 (1.05) と比較して有意に高値であった. 2) IL-6値とリンパ節転移度および肝転移の有無の間に有意な相関を認め, n2, 3 (+) 群の平均値 (10.20, 14.23) は, n (-) 群 (3.27) と比較して有意に高値であった. また, H'(+) 群の平均値 (18.57) はH0'群 (4.93) と比較して有意に高値であった. 3) IL-6値とHGF, ICAM-1, VCAM-1, E-selectinとの間に有意な相関を認めた. 4) IL-6値5.81以上を陽性とした場合, 全症例およびステージ別比較においてIL-6 高値群の累積生存率は低値群に比べ有意に不良であった. 5) IL-6 25pg/ml以上の全症例の腫瘍細胞質にIL-6の陽性所見を認めた. 結論: IL-6は大腸癌のリンパ節転移・肝転移成立に促進的に関与することが示唆され, その血清値は予後をよく反映し悪性度指標になりえる. |
| Author | 葦沢, 龍人 瀧本, 雅文 高木, 眞人 小柳, 泰久 青木, 利明 山崎, 達之 寿美, 哲生 青木, 達哉 丸山, 祥司 冨岡, 英則 |
| Author_xml | – sequence: 1 fullname: 瀧本, 雅文 organization: 東京都立豊島病院病理 – sequence: 1 fullname: 山崎, 達之 organization: 東京医科大学八王子医療センター消化器外科 – sequence: 1 fullname: 小柳, 泰久 organization: 東京医科大学外科 – sequence: 1 fullname: 葦沢, 龍人 organization: 東京医科大学八王子医療センター消化器外科 – sequence: 1 fullname: 丸山, 祥司 organization: 東京都立豊島病院外科 – sequence: 1 fullname: 青木, 達哉 organization: 東京医科大学外科 – sequence: 1 fullname: 青木, 利明 organization: 東京医科大学八王子医療センター消化器外科 – sequence: 1 fullname: 寿美, 哲生 organization: 東京医科大学八王子医療センター消化器外科 – sequence: 1 fullname: 高木, 眞人 organization: 東京医科大学八王子医療センター消化器外科 – sequence: 1 fullname: 冨岡, 英則 organization: 東京医科大学八王子医療センター消化器外科 |
| BookMark | eNo9j79KxEAYxBc5wXhe5XMk7maz3-6Wcv6FAxutw3ebzZkYoySxsDOCjSeChYVgeaAgCFr5PuH0fAsjJzYzzAwM_JZJJz_JLSGrjHpCcb6WpqPS49IDAQvEYTxQrubS7xCHcgWulqCWSK8skyGlQsk2M4ew6eRpdvXx9XDzffE-fbtv6pemvm7qu-ZynOSVLTJ7dpTkLjT16-fkcfZ8u0IWY8xK2_vzLjnY2tzv77iDve3d_vrATZlg6CLSSGtUfhxJMFZiBJHwAenQtKWVPgZxRDVSxSLwTUAFWmEAQAmwYDjvko35b1pWOLLhaZEcY3EeYlElJrPhLy7ToEMuQ5hLS_4_m0MswhT5D8xNYHo |
| ContentType | Journal Article |
| Copyright | 一般社団法人 日本消化器外科学会 |
| Copyright_xml | – notice: 一般社団法人 日本消化器外科学会 |
| DOI | 10.5833/jjgs.37.656 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1348-9372 |
| EndPage | 662 |
| ExternalDocumentID | article_jjgs1969_37_6_37_6_656_article_char_ja |
| GroupedDBID | 2WC ALMA_UNASSIGNED_HOLDINGS EBS EJD JSF KQ8 OK1 RJT |
| ID | FETCH-LOGICAL-j151a-aa0d99a82fd76ce7ad6d526a0bca82e72a4fd09a081d62c405ae5c666856e6c33 |
| ISSN | 0386-9768 |
| IngestDate | Wed Sep 03 06:30:22 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 6 |
| Language | Japanese |
| License | https://creativecommons.org/licenses/by-nc/4.0/deed.ja |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j151a-aa0d99a82fd76ce7ad6d526a0bca82e72a4fd09a081d62c405ae5c666856e6c33 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjgs1969/37/6/37_6_656/_article/-char/ja |
| PageCount | 7 |
| ParticipantIDs | jstage_primary_article_jjgs1969_37_6_37_6_656_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 2004 |
| PublicationDateYYYYMMDD | 2004-01-01 |
| PublicationDate_xml | – year: 2004 text: 2004 |
| PublicationDecade | 2000 |
| PublicationTitle | 日本消化器外科学会雑誌 |
| PublicationTitleAlternate | 日消外会誌 |
| PublicationYear | 2004 |
| Publisher | 一般社団法人 日本消化器外科学会 |
| Publisher_xml | – name: 一般社団法人 日本消化器外科学会 |
| References | 10) Kitamura N, Miyazawa K, Uehara Y et al: Gene expression and regulation of HGF-SF. EXS 65: 49-65, 1993 11) Liu Y, Tolbert EM, Sun AM et al: Primary struc-ture of rat HGF receptor and induced expression in glomerular mesangial cells. Am J Physiol 27: F679-688, 1996 31) 江上寛, 荒川博文, 小川道雄ほか: 手術侵襲とサイトカイン. 外科治療65: 149-155, 1991 23) Zhang G-J, Adachi I: Serum levels of soluble in-tercellular adhesion molecule-1 and E-selectin in metastatic breast carcinoma: correlations with clinicopathological features and prognosis. Int J Oncol 14: 71-77, 1999 33) Hirai T, Yamashita Y, Mukaida H et al: Poor prognosis in esophageal cancer patients with postoperative complications. Jpn J Surg 28: 576-579, 1998 7) Nishimura K, Kitamura M, Takada S et al: Regu-lation of invasive potential of human prostate can-cer cell lines by hepatocyte growth factor. Int J Urol 5: 276-281, 1998 2) 江上寛, 蒲原英伸, 小川道雄ほか: 大腸癌: 浸潤・転移の基礎と臨床6. 大腸癌の浸潤, 転移とサイトカイン. 日外会誌 99: 425-429, 1998 15) Ueda T, Shimada E, Urakawa T: Serum levels of cytokines in patients with colorectal cancer: Pos-sible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis. J Gastroenterol 29: 423-429, 1994 27) Belluco C, Nitti D, Frantz M et al: Interleukin-6 blood level is associated with circulating carci-noembryonic antigen and prognosis in patients with colorectal cancer. Ann Surg Oncol 7: 133-138, 2000 19) Haegeman G, Content J, Volckaert G et al: Struc-tural analysis of the sequence coding for an in-ducible 26-kDa protein in human fibroblasts. Eur J Biochem 159: 625-632, 1986 20) Hibi M, Murakami M, Saito M et al: Molecular cloning and expression of an IL-6 signal trans-ducer, gp130. Cell 63: 1149-1157, 1990 9) 葦沢龍人, 青木達哉, 寿美哲生ほか: 大腸癌進展におけるhepatocyte growth factor (HGF)の検討-Dukes 分類におけるHGF の臨床的意義-. 日消外会誌 35: 480-486, 2002 3) Jiang WG, Lloyds D, Puntis MCA et al: Regula-tion of spreading and growth of colon cancer cells by hepatocyte growth factor. Clin Exp Metastasis 11: 235-242, 1993 18) Zilberstein A, Ruggieri R, Korn JH et al: Struc-ture and expression of cDNA and genes for hu-man interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. EMBO J 5: 2529-2537, 1986 28) Gauldie J, Richards C, Harnish D et al: Interferonβ2/B-cell stimulatory factor type 2 shares iden-tity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci USA 84: 7251-7255, 1987 14) Akira S, Taga T, Kishimoto T: Interleukin-6 in biology and medicine. Adv Immunol 54: 1-78, 1993 25) Fong Y, Tracey KJ, Moldawer LL et al: Antibod-ies to cachectin/tumor necrosis factor reduce in-terleukin 1β and interleukin 6 appearance during lethal bacteremia. J Exp Med 170: 1627-1633, 1989 1) Tahara E: Growth factors and oncogenes in hu-man gastrointestinal carcinomas. J Cancer Res Clin Oncol 116: 121-131, 1990 13) Hirano T, Kishimoto T: Interleukin-6. Edited by Sporn MB. Handbook of experimental pharmacol-ogy. vol 95. Springer-Verlag, Berlin, 1990, p633-665 12) Hirano T, Yasukawa K, Harada H et al: Comple-mentary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73-76, 1986 22) Tamm I, Cardinale I, Sehgal PB: Interleukin-6 and 12-O-tetradecanoyl phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells. Cy-tokine 3: 212-223, 1991 29) Nijesten MWN, de Groot ER, ten Duis HJ et al: Serum levels of interleukin-6 and acute phase re-sponses. Lancet 2: 921, 1987 17) 大腸癌研究会編: 大腸癌取扱い規約. 第6版. 金原出版, 東京, 1998 24) Shalaby MR, Waage A, Aarden L et al: Endoxin, tumor necrosis factor-α and interleukin 1 induce interleukin 6 production in vivo. Clin Immunol Immunopathol 53: 488-498, 1989 5) Rubin JS, Chan A M-L, Bottaro DP et al: Abroad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci USA 88: 415-419, 1991 26) Gangopadhyay A, Lazure DA, Thomas P: Adhe-sion of colorectal carcinoma cells to the endothe-lium is mediated by cytokines from CEA stimu-lated Kupffer cells. Clin Exp Metastasis 16: 703-712, 1998 36 (662 8) Ueoka Y, Kato K, Kuriaki Y et al: Hepatocyte growth factor modulates motility and invasiven-ess of ovarian carcinomas via Ras-mediated pathway. Br J Cancer 82: 891-899, 2000 16) Takeda K, Fujii N, Nitta Y et al: Murine tumor cells metastasizing selectively in the liver: abil-ity to produce hepatocyte-activating cytokines interleukin-1 and/or -6. Jpn J Cancer Res 82: 1299-1308, 1991 6) Jin L, Fuchs A, Schnitt SJ et al: Expression of scatter factor and c-met receptor in benign and malignant breast tissue. Cancer 79: 749-760, 1997 30) Nishimoto N, Yoshizaki K, Tagoh H et al: Eleva-tion of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical opera-tion. Clin Immunol Immunopathol 50: 399-401, 1989 21) Fidler IJ: Selective of successive tumor lines for metastasis. Nat N Biol 242: 148-149, 1973 32) 浜田惇一, 武市紀年, 細川真澄男: 癌細胞の惡性化と正常細胞との相互作用. Mebio 9: 45-49, 1992 4) Matsumoto K, Date K, Shimura H et al: Acquisi-tion of invasive phenotype in gallbladder in can-cer cells via mutual interaction of stromal fibro-blasts and cancer cells as mediated by hepatocyte growth factor. Jpn J Cancer Res 87: 702-710, 1996 |
| References_xml | – reference: 14) Akira S, Taga T, Kishimoto T: Interleukin-6 in biology and medicine. Adv Immunol 54: 1-78, 1993 – reference: 30) Nishimoto N, Yoshizaki K, Tagoh H et al: Eleva-tion of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical opera-tion. Clin Immunol Immunopathol 50: 399-401, 1989 – reference: 13) Hirano T, Kishimoto T: Interleukin-6. Edited by Sporn MB. Handbook of experimental pharmacol-ogy. vol 95. Springer-Verlag, Berlin, 1990, p633-665 – reference: 17) 大腸癌研究会編: 大腸癌取扱い規約. 第6版. 金原出版, 東京, 1998 – reference: 28) Gauldie J, Richards C, Harnish D et al: Interferonβ2/B-cell stimulatory factor type 2 shares iden-tity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci USA 84: 7251-7255, 1987 – reference: 22) Tamm I, Cardinale I, Sehgal PB: Interleukin-6 and 12-O-tetradecanoyl phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells. Cy-tokine 3: 212-223, 1991 – reference: 20) Hibi M, Murakami M, Saito M et al: Molecular cloning and expression of an IL-6 signal trans-ducer, gp130. Cell 63: 1149-1157, 1990 – reference: 23) Zhang G-J, Adachi I: Serum levels of soluble in-tercellular adhesion molecule-1 and E-selectin in metastatic breast carcinoma: correlations with clinicopathological features and prognosis. Int J Oncol 14: 71-77, 1999 – reference: 11) Liu Y, Tolbert EM, Sun AM et al: Primary struc-ture of rat HGF receptor and induced expression in glomerular mesangial cells. Am J Physiol 27: F679-688, 1996 – reference: 2) 江上寛, 蒲原英伸, 小川道雄ほか: 大腸癌: 浸潤・転移の基礎と臨床6. 大腸癌の浸潤, 転移とサイトカイン. 日外会誌 99: 425-429, 1998 – reference: 7) Nishimura K, Kitamura M, Takada S et al: Regu-lation of invasive potential of human prostate can-cer cell lines by hepatocyte growth factor. Int J Urol 5: 276-281, 1998 – reference: 24) Shalaby MR, Waage A, Aarden L et al: Endoxin, tumor necrosis factor-α and interleukin 1 induce interleukin 6 production in vivo. Clin Immunol Immunopathol 53: 488-498, 1989 – reference: 9) 葦沢龍人, 青木達哉, 寿美哲生ほか: 大腸癌進展におけるhepatocyte growth factor (HGF)の検討-Dukes 分類におけるHGF の臨床的意義-. 日消外会誌 35: 480-486, 2002 – reference: 21) Fidler IJ: Selective of successive tumor lines for metastasis. Nat N Biol 242: 148-149, 1973 – reference: 31) 江上寛, 荒川博文, 小川道雄ほか: 手術侵襲とサイトカイン. 外科治療65: 149-155, 1991 – reference: 12) Hirano T, Yasukawa K, Harada H et al: Comple-mentary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73-76, 1986 – reference: 16) Takeda K, Fujii N, Nitta Y et al: Murine tumor cells metastasizing selectively in the liver: abil-ity to produce hepatocyte-activating cytokines interleukin-1 and/or -6. Jpn J Cancer Res 82: 1299-1308, 1991 – reference: 25) Fong Y, Tracey KJ, Moldawer LL et al: Antibod-ies to cachectin/tumor necrosis factor reduce in-terleukin 1β and interleukin 6 appearance during lethal bacteremia. J Exp Med 170: 1627-1633, 1989 – reference: 18) Zilberstein A, Ruggieri R, Korn JH et al: Struc-ture and expression of cDNA and genes for hu-man interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. EMBO J 5: 2529-2537, 1986 – reference: 33) Hirai T, Yamashita Y, Mukaida H et al: Poor prognosis in esophageal cancer patients with postoperative complications. Jpn J Surg 28: 576-579, 1998 – reference: 5) Rubin JS, Chan A M-L, Bottaro DP et al: Abroad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci USA 88: 415-419, 1991 – reference: 15) Ueda T, Shimada E, Urakawa T: Serum levels of cytokines in patients with colorectal cancer: Pos-sible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis. J Gastroenterol 29: 423-429, 1994 – reference: 19) Haegeman G, Content J, Volckaert G et al: Struc-tural analysis of the sequence coding for an in-ducible 26-kDa protein in human fibroblasts. Eur J Biochem 159: 625-632, 1986 – reference: 32) 浜田惇一, 武市紀年, 細川真澄男: 癌細胞の惡性化と正常細胞との相互作用. Mebio 9: 45-49, 1992 – reference: 29) Nijesten MWN, de Groot ER, ten Duis HJ et al: Serum levels of interleukin-6 and acute phase re-sponses. Lancet 2: 921, 1987 – reference: 27) Belluco C, Nitti D, Frantz M et al: Interleukin-6 blood level is associated with circulating carci-noembryonic antigen and prognosis in patients with colorectal cancer. Ann Surg Oncol 7: 133-138, 2000 – reference: 6) Jin L, Fuchs A, Schnitt SJ et al: Expression of scatter factor and c-met receptor in benign and malignant breast tissue. Cancer 79: 749-760, 1997 – reference: 1) Tahara E: Growth factors and oncogenes in hu-man gastrointestinal carcinomas. J Cancer Res Clin Oncol 116: 121-131, 1990 – reference: 3) Jiang WG, Lloyds D, Puntis MCA et al: Regula-tion of spreading and growth of colon cancer cells by hepatocyte growth factor. Clin Exp Metastasis 11: 235-242, 1993 – reference: 4) Matsumoto K, Date K, Shimura H et al: Acquisi-tion of invasive phenotype in gallbladder in can-cer cells via mutual interaction of stromal fibro-blasts and cancer cells as mediated by hepatocyte growth factor. Jpn J Cancer Res 87: 702-710, 1996 – reference: 8) Ueoka Y, Kato K, Kuriaki Y et al: Hepatocyte growth factor modulates motility and invasiven-ess of ovarian carcinomas via Ras-mediated pathway. Br J Cancer 82: 891-899, 2000 – reference: 26) Gangopadhyay A, Lazure DA, Thomas P: Adhe-sion of colorectal carcinoma cells to the endothe-lium is mediated by cytokines from CEA stimu-lated Kupffer cells. Clin Exp Metastasis 16: 703-712, 1998 36 (662) – reference: 10) Kitamura N, Miyazawa K, Uehara Y et al: Gene expression and regulation of HGF-SF. EXS 65: 49-65, 1993 |
| SSID | ssib005879761 ssib000936942 ssib023160767 ssib058493923 ssj0000491391 ssib002223853 |
| Score | 1.6375363 |
| Snippet | 目的: Interleukin-6 (IL-6) の血中レベルと大腸癌のリンパ節転移・肝転移との関連性および予後に及ぼす影響を検討し, IL-6の悪性度指標としての意義を明らかにする. 方... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 656 |
| Subtitle | 悪性度指標としての意義 |
| Title | 大腸癌進展におけるinterleukin-6の検討 |
| URI | https://www.jstage.jst.go.jp/article/jjgs1969/37/6/37_6_656/_article/-char/ja |
| Volume | 37 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本消化器外科学会雑誌, 2004, Vol.37(6), pp.656-662 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1348-9372 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000491391 issn: 0386-9768 databaseCode: KQ8 dateStart: 19690101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NaxQxFB9qvXgRRcVvejAnmTqbTL4OHpLtlCIoCC30NsynOMpW6vbiyRW8qAgePAgeCwqCoCf_Fq9Ltf4XvpfMdGfFg1VZGN4mL3nv5WV5v5dNMkFwRdaykBmtQ61pGca1zkMlijpUdJCXFD6M43nnm7fE2kZ8Y5NvLhz52tu1tDPOl4tHvz1X8jdehTLwK56SPYRnDzqFAqDBv_AED8Pzj3xMEk5MTIwkiSKKE6tIIonWRA1JonETg6XIYwdEc5IwgI3E2JZQpiX0wBGUKIuXR2zfr3bu3R2FomuQkESgGD1EMQYkJX1Ii7VaEsMdMSRmiIQVRCmUDapogQSoZVSrMZZI1BtlQ8kKMVASEwvMBlXX1lWBOAM9dLMCG4FRaG8nCmZIy6-8AiBXzvid7dYJsYCak44fzY6dRKDtHH9E1KrraZVY5vkFUlDR8vMZv0I1UXeBQ21o179NiFpx_Ia0SyHd0spsUdXVK7QI3afcyEkcHmiNA2aJYa1wdF_b2dX_PuC9YMCUCAE6-lhV-WDFYghWTM5FM3-FTvur7YcmwUUP5QgfA38NoHgGDwNoc-fhMpPLB23mbiRv53uKXHi7UspkKvwDGqRdNR4bTBvIXY5SCSgQN0zc7kF_fJNk3PtHH3BqHzpyJcHcg9gDaYiI5AwqA27WrEv9G5_pQjLjXpDZDZU_josmXesZBFCzgcSr27TpcOT6ieB4mwAuGa_-yWChyU4Fg73dd_tPv3x_8-LH4897n15PJx-mk2fTyavpk-dzv8np5OO33bf771-eDjZWk_XhWti-zCRsAFRnYZZFpdaZonUpRVHJrBQlpyKL8gIKK0mzuC4jnQFELwUtII_KKl4IIRQXlSgYOxMsjrZG1dlgqdBFnVPJ87iuIP-BkYQkJaqjisHXAaPnguvewvSBv7EmPZzHzv9j-wvBMb-_DRcqLwaL4-2d6hJA93F-2c2Bn9KXs_U |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%A4%A7%E8%85%B8%E7%99%8C%E9%80%B2%E5%B1%95%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8Binterleukin-6%E3%81%AE%E6%A4%9C%E8%A8%8E&rft.jtitle=%E6%97%A5%E6%9C%AC%E6%B6%88%E5%8C%96%E5%99%A8%E5%A4%96%E7%A7%91%E5%AD%A6%E4%BC%9A%E9%9B%91%E8%AA%8C&rft.au=%E7%80%A7%E6%9C%AC%2C+%E9%9B%85%E6%96%87&rft.au=%E5%B1%B1%E5%B4%8E%2C+%E9%81%94%E4%B9%8B&rft.au=%E5%B0%8F%E6%9F%B3%2C+%E6%B3%B0%E4%B9%85&rft.au=%E8%91%A6%E6%B2%A2%2C+%E9%BE%8D%E4%BA%BA&rft.date=2004&rft.pub=%E4%B8%80%E8%88%AC%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E6%B6%88%E5%8C%96%E5%99%A8%E5%A4%96%E7%A7%91%E5%AD%A6%E4%BC%9A&rft.issn=0386-9768&rft.eissn=1348-9372&rft.volume=37&rft.issue=6&rft.spage=656&rft.epage=662&rft_id=info:doi/10.5833%2Fjjgs.37.656&rft.externalDocID=article_jjgs1969_37_6_37_6_656_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0386-9768&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0386-9768&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0386-9768&client=summon |