Two Children with Lymphoid Malignancies in Relapse Successfully Treated with L-Phenylalanine Mustard

• Published in: The Japanese Journal of Pediatric Hematology Vol. 13; no. 6; pp. 448 - 453
• Main Authors: ISHIKAWA, Kumiko, ISHIDA, Yuhji, KIGASAWA, Hisato, NISHIHIRA, Hirokazu, TOYODA, Yasunori, ISHIKO, Yuka, KOH, Katuyoshi, OHNUMA, Kei, HONDA, Kohjiroh
• Format: Journal Article
• Language: Japanese
• Published: THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY 1999; 特定非営利活動法人 日本小児血液・がん学会
• Subjects: acute lymphoblastic leukemia; hematopoietic stem cell transplantation; L-phenylalanine mustard; leukemia/lymphoma syndrome; non-Hodgkin's lymphoma
• ISSN: 0913-8706; 1884-4723
• DOI: 10.11412/jjph1987.13.448

We reported two relapsed cases with leukemia/lymphoma syndrome (LLS) and non-Hodgkin's lymphoma (NHL) during chemotherapy, including cyclophosphamide and/or ifosfamide. After a second relapse, they received L-phenylalanine mustard with doses of 80 mg/m2 and achieved their third complete remission. Grade IV myelosuppression was a major toxicity in both cases. One patient with LLS relapsed four months later. This case underwent allogeneic bone marrow transplantation (BMT) from an unrelated donor after conditioning with busulfan, total body irradiation, and L-PAM in her third bone marrow relapse. She is still in complete remission three years after BMT. These results indicate that L-PAM has a strong antitumor activity for childhood lymphoid malignancies.