Two Children with Primary Mediastinal Large B Cell Lymphoma

• Published in: The Japanese Journal of Pediatric Hematology Vol. 13; no. 2; pp. 111 - 116
• Main Authors: TOKIMASA, Sadao, NAKANISHI, Koji, OKADA, Shintaro, MATSUDA, Yoshiko, OSUGI, Yuko, FUJISAKI, Hiroyuki, OHTA, Hideaki, TAKAI, Kenji, HARA, Junichi
• Format: Journal Article
• Language: Japanese
• Published: THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY 1999; 特定非営利活動法人 日本小児血液・がん学会
• Subjects: chemotherapy; childhood; primary mediastinal large B cell lymphoma
• ISSN: 0913-8706; 1884-4723
• DOI: 10.11412/jjph1987.13.111

We report two children with primary mediastinal large B cell lymphoma (PMLCL). Patient 1, a 10-year-old girl, presented with engorged veins on the chest and abdominal wall. MR image revealed a large mediastinal mass that invaded and occluded the superior vena cava. Patient 2, a 14-year-old boy, presented with swallowing discomfort and dry cough. Imaging study showed a huge mediastinal mass and pleural effusions. In both patients, the tumor cells showed mature B cell phenotype, and histopathology in patient 2 showed diffuse large-cell lymphoma with sclerosis. We treated them with an intensive short-term chemotherapy regimen “B-93 protocol.” Both patients showed good response initially, but residual tumors were observed after the completion of chemotherapy. We confirmed complete remission by open biopsy in patient 1 and imaging study in patient 2. These two cases suggest that residual tumors of PMLCL are due to sclerosis and that they do not always show a resistance to treatment.