Significance of Histopathological Examination on Hematological Disorder

• Published in: The Japanese Journal of Pediatric Hematology Vol. 17; no. 5; pp. 438 - 441
• Main Authors: ZAIKE, Yuuji, MASUNAGA, Atsuko
• Format: Journal Article
• Language: Japanese
• Published: THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY 2003; 特定非営利活動法人 日本小児血液・がん学会
• Subjects: bone marrow; clot section; histopathology; trephine biopsy
• ISSN: 0913-8706; 1884-4723
• DOI: 10.11412/jjph1987.17.438

We announce how to take formalin-fixed material from an aspirated bone marrow clot by bedside. On histological specimen, we can not only recognize cellularity, but also know the extent of fibrosis and the existence of tumor proliferation. On the other hand, a bone marrow smear shows whether or not there are dysplastic cells. We can also count the cells in the bone marrow smear in order to learn the cell ratio (myelogram). In this way, the histological specimen and bone marrow smear have different benefits and play compensatory roles. We can use both specimens not only to make a diagnosis, but also to learn the disease stage, which is then followed by the decision of treatment direction.