BASIC AND CLINICAL STUDIES ON 7432-S

• Published in: CHEMOTHERAPY Vol. 37; no. Supplement1; pp. 178 - 183
• Main Authors: FUJUTA, TAKANORI, FUKUI, TOSHIO, KATSU, MASATAKA, OKUI, SHINJI, TOGO, TOSHIHITO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 30.11.1989
• Subjects: New oral cephem
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.37.Supplement1_178

Basic and clinical studeis on 7432-S, a new oral cephem antibiotic, were carried out and the following results obtained. The in vitro antibacterial activity of 7432-S was tested against 135 clinical isolates of 9 species and compared with that of cefaclor, T-2525, cefixime, ampicillin, imipenam, ofloxacin and minocycline. 7432-S was more effective against Gram-negative bacteria (Escherichia coli, Klebsiella pneum.oniae, Proteus vulgaris, Providencia rettgeri, Morganella morganii, Enterobacter cloacae, Serratia marcescens and Haemophilus influenzae) than any other antibiotic tested, but less active against Gram-positive cocci (Streptococcus pyogenes). We administered 7432-S to 6 patients with respiratory and 2 with urinary tract infection at a dose of 300-400mg daily in 2 or 3 divided doses for 7-15 days. The clinical efficacy rate was 71.4% in all 7 cases except one, which was unknown. The organisms isolated from 3 cases, 2 strains of Streptococcus agalactiae and 1 of Enterococcus faecalis, were eradicated except E. faecalis. There were no side effects or abnormal laboratory findings.