A case of hilar bile duct carcinoma who was able to undergo a curative resection after intrahepatic arterial infusion chemotherapy

• Published in: Tando Vol. 18; no. 2; pp. 211 - 216
• Main Authors: TAKEMOTO, Norikazu, TAMESA, Takao, SAKAMOTO, Kazuhiko, OKA, Masaaki
• Format: Journal Article
• Language: Japanese
• Published: Japan Biliary Association 2004
• Subjects: hepatectomy combined with resection of vessels; hilar bile duct carcinoma; preoperative intrahepatic artery infusion chemotherapy; 肝門部胆管癌; 血管合併切除再建肝切除; 術前肝動注化学療法
• ISSN: 0914-0077; 1883-6879
• DOI: 10.11210/tando1987.18.2_211

A 50-year-old woman had unresectable hilar bile duct carcinoma because of involvement of the right hepatic artery (RHA) and left portal vein (LPV) and low hepatic function for surgery. After insertion of a bile duct stent, she was treated by continuous intrahepatic arterial infusion chemotherapy with low-dose cisplatin (CDDP) and 5-fluorouracil (5-FU) via an implanted reservoir. This chemotherapy consisted of 10 mg of CDDP and 250 mg of 5-FU,5 days/week, for 4 weeks. Since this therapy induced reduction of involvement of RHA and LPV, we performed extended left hepatectomy and caudate lobectomy with reconstruction of RHA and LPV. Most of all cancer cells were disappeared, but a few cancer cells remained in connective tissue around the bile duct. This patient is still alive 3 years and 9 months after surgery.